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Retinoblastoma-Like 2 (p130) (RBL2) (AA 26-367) antibody

Details for Product No. ABIN967863
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Antigen
Synonyms RBL2, RBR2, RRB2a, PRB2, RBR-2, Rb2, p130, P130
Epitope
AA 26-367
(14), (9), (8), (5), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(98), (50), (48), (37), (37), (23), (3), (2), (2), (2), (1)
Host
Mouse
(78), (24)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(57), (36), (29), (26), (23), (11), (7), (6), (5), (1)
Pubmed 5 references available
Quantity 50 µg
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Catalog No. ABIN967863
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Immunogen Human Rb2
Clone 4B9
Isotype IgG2a
Cross-Reactivity Mouse (Murine), Rat (Rattus), Chicken, Fruit Fly (Drosophila melanogaster)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Rb2
Background The pRb2 protein shows a high degree of identity with pRb and the related p107 protein. Both pRb and p107 bind to the adenovirus E1A, SV40 large T antigen, and papillomavirus E7 viral proteins. This binding initiates the release of transcription factors which are required for the expression of cell cycle-regulated genes. pRb, pRb2, and p107 interact with a conserved motif in these three viral proteins. In the E1A protein, this area is known as transforming domain 2, which is required for growth activation. The E1A-binding domain in pRb and p107 is a conserved motif known as the pocket region which consists of conserved A and B regions separated by non-conserved spacers of different sizes in pRb and p107. It is the pocket regions of pRb and p107 that associate with the E2F transcription factor. pRb2 also contains the conserved pocket region suggesting that it has functional similarities to pRb and p107. This antibody is routinely tested by western blot analysis.
Molecular Weight 130 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 26-367) antibody Western blot analysis of Rb2 on a Jurkat cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the anti- Rb2 antibody.
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 26-367) antibody (2) Immunofluorescent staining of rabbit lung.
Product cited in: Yeung, Bell, Testa et al.: "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19." in: Oncogene, Vol. 8, Issue 12, pp. 3465-8, 1993 (PubMed).

Mayol, Graña, Baldi et al.: "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain." in: Oncogene, Vol. 8, Issue 9, pp. 2561-6, 1993 (PubMed).

Saitoh, Pizzi, Wang: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, 2002 (PubMed).

Fusaro, Wang, Chellappan: "Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis." in: Oncogene, Vol. 21, Issue 29, pp. 4539-48, 2002 (PubMed).

Laplantine, Rossi, Sahni et al.: "FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest." in: The Journal of cell biology, Vol. 158, Issue 4, pp. 741-50, 2002 (PubMed).

Validation Images
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