p130 antibody (AA 939-1139)
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- Target See all p130 (RBL2) Antibodies
- p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
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Binding Specificity
- AA 939-1139
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This p130 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Flow Cytometry (FACS)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human RBL2 (AA: 939-1139) expressed in E. coli.
- Clone
- 2C8A8
- Isotype
- IgG1
- Top Product
- Discover our top product RBL2 Primary Antibody
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anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 165-194), (N-Term) antibody
RBL2 Reactivity: Human WB, FACS Host: Rabbit Polyclonal RB31021 unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 878-913) antibodyRBL2 Reactivity: Human, Rat WB, IF, IHC, IP, IHC (p) Host: Mouse Monoclonal 130P215 unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 100-200) antibodyRBL2 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 417-616) antibodyRBL2 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (C-Term) antibodyRBL2 Reactivity: Human, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) antibodyRBL2 Reactivity: Human, Rat, Mouse WB Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) antibodyRBL2 Reactivity: Human, Rat, Mouse ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) (AA 416-515) antibodyRBL2 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) antibodyRBL2 Reactivity: Human, Chimpanzee WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Retinoblastoma-Like 2 (p130) (RBL2) antibodyRBL2 Reactivity: Human, Rat, Mouse ELISA, IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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- Target
- p130 (RBL2) (Retinoblastoma-Like 2 (p130) (RBL2))
- Alternative Name
- RBL2 (RBL2 Products)
- Synonyms
- RBL2 antibody, RBR2 antibody, RRB2a antibody, PRB2 antibody, RBR-2 antibody, Rb2 antibody, p130 antibody, P130 antibody, retinoblastoma-like 2 (p130) antibody, RB transcriptional corepressor like 2 antibody, related to retinoblastoma 2 antibody, RBL2 antibody, LOC541652 antibody, Rbl2 antibody
- Background
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Description: RBL2 is a Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Aliases: Rb2, P130
- Molecular Weight
- 128.4 kDa
- Gene ID
- 5934
- HGNC
- 5934
- Pathways
- Cell Division Cycle, Mitotic G1-G1/S Phases
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