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Jun Proto-Oncogene (JUN) (AA 26-175) antibody

Antigen

Jun Proto-Oncogene (JUN)
Synonyms AP1, AP-1, c-Jun, fj36h07, zgc:65863, wu:fj36h07, jun
Binding Site
Alternatives

AA 26-175
Clonality Monoclonal (3)
Host
Alternatives

Mouse
Reactivity
Alternatives

Mouse (Murine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP)
5 references available
Catalog no. ABIN967903
Quantity
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anti-Jun Proto-Oncogene (JUN) (AA 26-175) antibody

anti-Jun Proto-Oncogene (JUN) (AA 26-175) antibody (2)

anti-Jun Proto-Oncogene (JUN) (AA 26-175) antibody (3)

Additional Information
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Alternative name Jun
Immunogen Mouse c-Jun
Cross-Reactivity Human, Chicken, Dog (Canine), Rat (Rattus)
Format Liquid
Isotype IgG2a
Clone 3
Description The activator protein transcription factor (AP-1) was identified as a protein that recognizes specific sequences in the cis-control regions of the SV40 virus and the human metallothionein IIA gene. AP-1 is composed of protein products of two different gene families: jun and fos. The AP-1 transcription factor is either a homodimer of Jun proteins or a heterodimer of Jun and Fos proteins. The transcriptional activity of Jun is enhanced by phosphorylation in its activation domain at Ser63 and Ser73. Phosphorylation at both sites is necessary for stimulating the activating function of Jun. Jun is phosphorylated by JNK protein kinases that are activated by the same signals that potentiate Jun activity. This antibody is routinely tested by western blot analysis.
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Molecular Weight 39 kDa
Comments

Related Products: ABIN968536, ABIN967389

Application Details
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Concentration 250 µg/ml
Purity Purified
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative 0.09% Sodium azide.
Storage Store undiluted at -20° C.
Restrictions For Research Use only

Publications
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Product Lamph, Wamsley, Sassone-Corsi et al.: "Induction of proto-oncogene JUN/AP-1 by serum and TPA." in: Nature, Vol. 334, Issue 6183, pp. 629-31, 1988 (PubMed).

Taupin, Wu, Jeon et al.: "The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation." in: The Journal of clinical investigation, Vol. 103, Issue 9, pp. R31-8, 1999 (PubMed).

Chang, Nakajima, Illenye et al.: "Caspase-dependent apoptosis by ectopic expression of E2F-4." in: Oncogene, Vol. 19, Issue 41, pp. 4713-20, 2000 (PubMed).

He, Stepulak, Holmström et al.: "The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase." in: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 10767-74, 2002 (PubMed).

Doray, Ghosh, Griffith et al.: "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network." in: Science (New York, N.Y.), Vol. 297, Issue 5587, pp. 1700-3, 2002 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Jun Proto-Oncogene (JUN)", type "Antibodies"
Hosts Rabbit (349), Mouse (9), Chicken (1), Goat (1), Sheep (1)
Reactivities Human (351), Rat (Rattus) (198), Mouse (Murine) (190), Cow (Bovine) (87), Dog (Canine) (86), Pig (Porcine) (82), Chicken (77), Sheep (Ovine) (62), Horse (Equine) (25), Xenopus laevis (8), Rabbit (7), Monkey (5), Zebrafish (5), Fruit Fly (Drosophila melanogaster) (3), Guinea Pig (3), Hamster (3), Cat (Feline) (1)
Applications Western Blotting (WB) (254), Immunohistochemistry (IHC) (125), ELISA (118), Immunofluorescence (IF) (101), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (72), Immunoprecipitation (IP) (42), Dot Blot (Dot) (6), Immunocytochemistry (ICC) (6), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (5), Flow Cytometry (FACS) (3), Immunoelectron Microscopy (IEM) (2), Immunohistochemistry (Fixed) (IHC (fx)) (1)
Conjugates Alexa Fluor 350 (10), Alexa Fluor 555 (10), Alexa Fluor 647 (10), Alexa Fluor 488 (9), PE,Cy5.5 (9), Biotin (2), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), FITC (2), Gold (2), HRP (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2), PE-Cy5.5 (1)
Epitopes pSer73 (26), pSer63 (20), pThr239 (19), pTyr170 (18), pThr91 (17), pThr93,pThr91 (17), pSer243 (16), Internal Region (12), pThr93 (12), C-Term (8), pThr249 (8), N-Term (7), Ser73 (5), Thr239 (4), pThr91,pThr93 (4), Ser243 (3), Ser63 (3), Tyr170 (3), pThr243 (3), AA 266-285 (2), Thr243 (2), Thr249 (2), Thr91 (2), Thr93 (2), pThr91, pThr93 (2), AA 1-240 (1), AA 59-67 (1), C-Term,Glu248 (1), Middle Region (1), Ser73,Phosphospecific (1), Sumoylation Site (1), non-pSer73 (1), pSer213 (1), pSer539,pSer535 (1), pThr18 (1), pThr231 (1), pTyr981,pTyr980 (1)