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Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 94-208) antibody

Details for Product No. ABIN967944
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Antigen
Synonyms MORT1, Mort1/FADD, Mort1, TNFRSF6
Epitope
AA 94-208
(31), (30), (14), (13), (10), (9), (8), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(136), (63), (33), (12), (4), (2), (1)
Host
Mouse
(138), (50), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(7), (7), (7), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3)
Application
Western Blotting (WB), Immunofluorescence (IF)
(136), (96), (43), (40), (24), (17), (8), (6), (2), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 50 µg
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Catalog No. ABIN967944
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  • +1 404 474 4654
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Immunogen Human FADD
Clone 1
Isotype IgG1
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name FADD
Background During apoptosis, cells exhibit morphological signs of the death process: cell shrinkage, membrane blebbing, and chromatin condensation. The role of the cell surface cytokine receptor, Fas (Apo-1, CD95), in apoptosis has been well characterized. The tumor necrosis factor receptor (TNF-R) can trigger cell death, as well as various other responses. Data suggested that Fas and TNF-R affect a common target in the cell death pathway. This target has been identified as FADD, a novel protein that contains a death domain homologous to the death domains of Fas and TNF-R1. FADD specifically binds to Fas, an association mediated by their homologous death domains. Overexpression of FADD induces apoptosis that is inhibited by CrmA, a poxvirus protein that blocks both Fas- and TNF-induced cell death. Thus, FADD is a central element of the Fas-mediated cell death pathway. This antibody is routinely tested by western blot analysis.
Molecular Weight 24 kDa
Research Area Cancer, Apoptosis/Necrosis
Comment

Related Products: ABIN968533, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 94-208) antibody Western blot analysis of FADD on a A431 lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- FADD antibody.
anti-Fas (TNFRSF6)-Associated Via Death Domain (FADD) (AA 94-208) antibody (2) Immunoflourescence staining of MDCK cells.
Product cited in: Chinnaiyan, ORourke, Tewari et al.: "FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis." in: Cell, Vol. 81, Issue 4, pp. 505-12, 1995 (PubMed).

Wieder, Essmann, Prokop et al.: "Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3." in: Blood, Vol. 97, Issue 5, pp. 1378-87, 2001 (PubMed).

Chang, Xing, Pan et al.: "c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis." in: The EMBO journal, Vol. 21, Issue 14, pp. 3704-14, 2002 (PubMed).

Micheau, Thome, Schneider et al.: "The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45162-71, 2002 (PubMed).

MacFarlane, Harper, Snowden et al.: "Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia." in: Oncogene, Vol. 21, Issue 44, pp. 6809-18, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN967944
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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