EPH Receptor A4 antibody (EPHA4) (AA 279-472)

Details for Product anti-EPHA4 Antibody No. ABIN967994, Supplier: Log in to see
Antigen
  • HEK8
  • SEK
  • TYRO1
  • RGD1560587
  • ephe
  • EPHA4
  • Ci-Eph1
  • sek
  • hek8
  • rtk1
  • tyr01
  • 2900005C20Rik
  • AI385584
  • Cek8
  • Hek8
  • Sek
  • Sek1
  • Tyro1
  • rb
  • XEpha4
  • epha4
  • pag
  • sek-1
  • EphA4
  • apha3
  • ek2
  • epha3
  • sb:cb246
  • zek2
  • zgc:109882
  • EPH receptor A4
  • Eph receptor A4
  • ephrin receptor epsilon
  • EPH receptor A4 L homeolog
  • eph receptor A4a
  • EPHA4
  • Epha4
  • ephe
  • epha4
  • epha4.L
  • epha4a
Alternatives
anti-Mouse (Murine) EPH Receptor A4 antibody for Western Blotting
Epitope
AA 279-472
30
21
20
15
13
12
11
10
7
5
4
4
4
3
2
2
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
155
71
36
10
10
9
7
7
7
6
4
3
2
2
2
2
2
1
1
1
Host
Mouse
149
22
17
1
Clonality (Clone)
Monoclonal ()
Conjugate
This EPH Receptor A4 antibody is un-conjugated
9
8
8
6
6
6
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
132
84
83
51
18
17
13
7
3
2
1
1
Options
Supplier
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Supplier Product No.
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Immunogen Mouse Sek aa. 279-472
Clone 35-EphA4
Isotype IgG1
Cross-Reactivity Rat (Rattus), Human, Dog (Canine), Chicken
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name EphA4 (EPHA4 Antibody Abstract)
Background EphA4/Sek is a glycosylated protein tyrosine kinase of 986 amino acids and an apparent 110-130kDa molecular weight (molecular weight depends on glycocylation level of protein). EphA4 belongs to the Eph subfamily of receptor tyrosine kinases and like many others, it has an amino-terminal ligand-binding domain exposed to the extracellar matrix. EphA4 is predominantly expressed during development (this is common in the Eph family) and because of its mRNA localization, it has been proposed that it may play a role during segmentation of the hindbrain and mesoderm. Tyrosine 602 is a major autophosphorylation site of EphA4 and appears to be the docking site for the intracellular tyrosine kinase fyn.
Molecular Weight 110-130 kDa
Pathways RTK Signaling
Comment

Related Products: ABIN967389, ABIN968545

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.
Supplier Images
Western Blotting (WB) image for anti-EPH Receptor A4 (EPHA4) (AA 279-472) antibody (ABIN967994) Western blot analysis of EphA4 on rat brain lysate. Lane 1: 1:1000, lane 2: 1:2000, l...
Immunofluorescence (IF) image for anti-EPH Receptor A4 (EPHA4) (AA 279-472) antibody (ABIN967994) Immunofluorescence staining of PC12 cells
 image for anti-EPH Receptor A4 (EPHA4) (AA 279-472) antibody (ABIN967994) anti-EPH Receptor A4 (EPHA4) (AA 279-472) antibody (Image 3)
Product cited in: Ellis, Kasmi, Ganju, Walls, Panayotou, Reith: "A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn." in: Oncogene, Vol. 12, Issue 8, pp. 1727-36, 1996 (PubMed).

Becker, Gilardi-Hebenstreit, Seitanidou, Wilkinson, Charnay: "Characterisation of the Sek-1 receptor tyrosine kinase." in: FEBS letters, Vol. 368, Issue 2, pp. 353-7, 1995 (PubMed).

Gilardi-Hebenstreit, Nieto, Frain, Mattéi, Chestier, Wilkinson, Charnay: "An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain." in: Oncogene, Vol. 7, Issue 12, pp. 2499-506, 1993 (PubMed).

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