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Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody

Antigen

Discs, Large Homolog 4 (Drosophila) (DLG4)
Synonyms
PSD95, SAP90, SAP-90, FLJ97752, FLJ98574, DAP2, SAPAP2, Dlgh4, PSD-95, SAP90A, Sap90, 11, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, CG1725, CG1730, CPD, d. lg.-1 ... show more
Binding Site
Alternatives

AA 353-504
Clonality Monoclonal (16)
Host
Alternatives

Mouse
Reactivity
Alternatives

Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunofluorescence (IF)
5 references available
Catalog no. ABIN968002
Quantity 50 µg  (250 µg/ml)  (Variants)
Price Product not available in this region.
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anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody

anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody (2)

Additional Information
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Alternative name PSD-95
Immunogen Rat PSD-95
Cross-Reactivity Mouse (Murine)
Format Liquid
Isotype IgG1
Clone 16
Description PostSynaptic Density (PSD) refers to a dense region of submembranous cytoskeleton found most prominently in postsynaptic membranes of the CNS. Possible functions for the PSD include regulation and aggregation of receptors, structural stabilization of the synaptic junction, and transduction of signals from membrane receptors. Some of the proteins associated with the PSD are fodrin, tubulin, calmodulin, CaM Kinase II, PSD-95, and PSD-93. PSD-95 (SAP90) is a protein that interacts with the NMDA receptor NMDAR2B, neuronal NOS (nNOS or bNOS), and other proteins. PSD-95 contains one SH3 domain in its carboxy-terminal domain, as well as three conserved repeat regions called GLGF or PDZ domains. nNOS, which is concentrated in synaptic junctions, also contains a PZD domain. PSD-95 and nNOS interact via their respective PZD domains, which may mediate the binding of nNOS to skeletal muscle syntrophin. This antibody is routinely tested by western blot analysis.
Synonyms: PostSynaptic Density-95, SAP90
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Molecular Weight 95 kDa
Comments

Related Products: ABIN968545, ABIN967389
Synonyms PSD95, SAP90, SAP-90, FLJ97752, FLJ98574, DAP2, SAPAP2, Dlgh4, PSD-95, SAP90A, Sap90, 11, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, CG1725, CG1730, CPD, d. lg.-1, Discs-large, dlg, Dlg, DLG, dlg-1, dlg-A, Dlg-A, DLG-A, Dlg1, dlgA, DlgA, DmelCG1725, Drodlg, l(1)10Bf, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)l.pr.-2, l(1)L11, l(1)lpr-2, misb, SAP97, Sapap2, 6430596N04Rik, dlgh4, psd95, sap90, sap-90, LLGL1

Application Details
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Concentration 250 µg/ml
Purity Purified
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative 0.09% Sodium azide.
Storage Store undiluted at -20° C.
Restrictions For Research Use only

Publications
Application Details Images Alternatives Variants back to top

Product Cho, Hunt, Kennedy: "The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein." in: Neuron, Vol. 9, Issue 5, pp. 929-42, 1992 (PubMed).

Brenman, Chao, Gee et al.: "Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains." in: Cell, Vol. 84, Issue 5, pp. 757-67, 1996 (PubMed).

Mehta, Wu, Garner et al.: "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16092-9, 2001 (PubMed).

Fallon, Moreau, Croft et al.: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, 2002 (PubMed).

Fagiolini, Katagiri, Miyamoto et al.: "Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2854-9, 2003 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Discs, Large Homolog 4 (Drosophila) (DLG4)", type "Antibodies"
Hosts Rabbit (40), Mouse (29), Goat (3), Rat (1)
Reactivities Rat (Rattus) (61), Mouse (Murine) (51), Human (49), Cow (Bovine) (38), Dog (Canine) (24), Pig (Porcine) (23), Rabbit (1), Zebrafish (Danio rerio) (1)
Applications Western Blotting (WB) (53), Immunofluorescence (IF) (32), Immunocytochemistry (ICC) (17), ELISA (12), Immunoprecipitation (IP) (12), Immunohistochemistry (IHC) (9), Immunohistochemistry (Frozen Sections) (IHC (fro)) (5), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunoelectron Microscopy (IEM) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Flow Cytometry (FACS) (2), Immunostaining (ISt) (2)
Conjugates Alexa Fluor 350 (2), Alexa Fluor 488 (2), Alexa Fluor 555 (2), Alexa Fluor 647 (2), PE,Cy5.5 (2), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr240,pTyr236 (4), Internal Region (3), pSer295,Internal Region (3), C-Term (2), Center (1), N-Term (1), Ser295 (1), pSer295 (1), pSer418 (1), pTyr340 (1)