Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody

Details for Product No. ABIN968003
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Antigen
Synonyms
11, CG1725, CG1730, CPD, DLG, DLG-A, Discs-large, Dlg, Dlg-A, Dlg1, DlgA, Dmel\\CG1725, Drodlg, PSD95, SAP97, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, d. lg.-1, ... show more
11, CG1725, CG1730, CPD, DLG, DLG-A, Discs-large, Dlg, Dlg-A, Dlg1, DlgA, Dmel\\CG1725, Drodlg, PSD95, SAP97, anon-EST:Posey93, anon-WO03040301.258, anon-WO03040301.260, anon-WO03040301.268, d. lg.-1, dlg, dlg-1, dlg-A, dlgA, dlgS97, l(1)10Bf, l(1)G0276, l(1)G0342, l(1)G0456, l(1)G19, l(1)L11, l(1)bwn, l(1)d.lg-1, l(1)d.lg.-1, l(1)discs large, l(1)dlg, l(1)dlg-1, l(1)dlg1, l(1)l.pr.-2, l(1)lpr-2, misb, dlgh4, psd95, sap90, sap-90, LLGL1, Dlgh4, PSD-95, SAP90, SAP90A, Sap90, SAP-90, DLG4 show less
Epitope
AA 353-504
(18), (12), (12), (8), (7), (5), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Rat (Rattus)
(111), (84), (60), (42), (25), (24), (2), (2), (1), (1), (1), (1), (1)
Host
Mouse
(86), (57), (3), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunofluorescence (IF)
(129), (65), (61), (33), (29), (20), (18), (15), (11), (5), (2), (2), (2)
Pubmed 5 references available
Quantity 150 µg
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Catalog No. ABIN968003
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Immunogen Rat PSD-95
Clone Ghr6
Isotype IgG1
Cross-Reactivity Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name PSD-95
Background PostSynaptic Density (PSD) refers to a dense region of submembranous cytoskeleton found most prominently in postsynaptic membranes of the CNS. Possible functions for the PSD include regulation and aggregation of receptors, structural stabilization of the synaptic junction, and transduction of signals from membrane receptors. Some of the proteins associated with the PSD are fodrin, tubulin, calmodulin, CaM Kinase II, PSD-95, and PSD-93. PSD-95 (SAP90) is a protein that interacts with the NMDA receptor NMDAR2B, neuronal NOS (nNOS or bNOS), and other proteins. PSD-95 contains one SH3 domain in its carboxy-terminal domain, as well as three conserved repeat regions called GLGF or PDZ domains. nNOS, which is concentrated in synaptic junctions, also contains a PZD domain. PSD-95 and nNOS interact via their respective PZD domains, which may mediate the binding of nNOS to skeletal muscle syntrophin. This antibody is routinely tested by western blot analysis.
Synonyms: PostSynaptic Density-95, SAP90
Molecular Weight 95 kDa
Comment

Related Products: ABIN968545, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody Western blot analysis of PSD-95 on a rat cerebrum lysate. Lane1: 1:250, lane 2: 1: 500, lane 3: 1:1000 dilution of the mouse anti- PSD-95 antibody.
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody (2) Immunofluorescence staining of PC12 cells (Rat neuroblastoma, ATCC CRL-1721).
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody (3) anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (AA 353-504) antibody (Image 3)
Product cited in: Cho, Hunt, Kennedy: "The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein." in: Neuron, Vol. 9, Issue 5, pp. 929-42, 1992 (PubMed).

Brenman, Chao, Gee et al.: "Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains." in: Cell, Vol. 84, Issue 5, pp. 757-67, 1996 (PubMed).

Mehta, Wu, Garner et al.: "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97." in: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 16092-9, 2001 (PubMed).

Fallon, Moreau, Croft et al.: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, 2002 (PubMed).

Fagiolini, Katagiri, Miyamoto et al.: "Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2854-9, 2003 (PubMed).

Validation Images
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