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Paxillin (PXN) (AA 1-557) antibody

Antigen

Paxillin (PXN)
Synonyms FLJ16691, Pax, AW108311, AW123232, CG18061, CG18576, CT40481, CT42454, DPaxillin, DPxn, DPxn37, Dpax, PDLP, DmelCG31794, CG31794, LOC397826, wu:fw71f12, PXN, DKFZp469J2119, LOC100220858
Binding Site
Alternatives

AA 1-557
Clonality Monoclonal (165)
Host
Alternatives

Mouse
Reactivity
Alternatives

Chicken
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
4 references available
Catalog no. ABIN968067
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anti-Paxillin (PXN) (AA 1-557) antibody

anti-Paxillin (PXN) (AA 1-557) antibody (2)

Additional Information
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Alternative name Paxillin
Immunogen Chicken Paxillin
Cross-Reactivity Human, Dog (Canine), Rat (Rattus), Mouse (Murine)
Format Liquid
Isotype IgG1
Clone 165
Description Paxillin, a focal adhesion protein, is a substrate for several tyrosine kinases such as src, FAK, and p120BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. This is consisent with the possibility that paxillin is involved in the regulation of cell morphology. Additionally, because of its SH3 binding domain, paxillin associates tightly with FAK and Crk in an extracellular matrix-independent manner. Paxillin was initially detected in fibroblasts, and its phosphorylation may be important during neurite extension during differentiation. This antibody is routinely tested by western blot analysis.
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Molecular Weight 68 kDa
Comments

Related Products: ABIN968536, ABIN967389

Application Details
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Concentration 250 µg/ml
Purity Purified
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative 0.09% Sodium azide.
Storage Store undiluted at -20° C.
Research Area Cancer, Extracellular Matrix
Restrictions For Research Use only

Publications
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Product Turner, Glenney, Burridge: "Paxillin: a new vinculin-binding protein present in focal adhesions." in: The Journal of cell biology, Vol. 111, Issue 3, pp. 1059-68, 1990 (PubMed).

Salgia, Li, Lo et al.: "Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL." in: The Journal of biological chemistry, Vol. 270, Issue 10, pp. 5039-47, 1995 (PubMed).

Müller, Jung, Wied et al.: "Redistribution of glycolipid raft domain components induces insulin-mimetic signaling in rat adipocytes." in: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4553-67, 2001 (PubMed).

Laukaitis, Webb, Donais et al.: "Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells." in: The Journal of cell biology, Vol. 153, Issue 7, pp. 1427-40, 2001 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "Paxillin (PXN)", type "Antibodies"
Hosts Rabbit (146), Mouse (18), Sheep (1)
Reactivities Human (152), Mouse (Murine) (75), Rat (Rattus) (74), Dog (Canine) (24), Cow (Bovine) (23), Horse (Equine) (23), Chicken (12), Monkey (1), Xenopus laevis (1), Zebrafish (Danio rerio) (1)
Applications Western Blotting (WB) (105), Immunofluorescence (IF) (62), Immunohistochemistry (IHC) (35), ELISA (33), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (31), Immunocytochemistry (ICC) (15), Immunoprecipitation (IP) (10), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (5), Flow Cytometry (FACS) (2), Dot Blot (Dot) (1), Immunoelectron Microscopy (IEM) (1), Immunohistochemistry (Fixed) (IHC (fx)) (1)
Conjugates Alexa Fluor 350 (6), Alexa Fluor 488 (6), Alexa Fluor 555 (6), Alexa Fluor 647 (6), PE,Cy5.5 (6), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr118 (18), pTyr31 (16), pTyr88 (10), Tyr118 (5), pSer178 (5), pSer83 (5), C-Term (4), AA 356-558 (3), AA 59-274 (2), N-Term (2), Tyr31 (2), Tyr88 (2), pSer126 (2), AA 112-126 (1), AA 305-559 (1), Center (1), Internal Region (1), pSer17 (1), pSer23 (1), pThr383,pThr382,pSer380 (1), pTyr181 (1), pTyr753 (1)