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Small Nuclear Ribonucleoprotein N (SNRPN) (AA 14-174) antibody

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AA 14-174
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(3), (1), (1), (1)
(2), (1)
Clonality (Clone)
Monoclonal ()
BioImaging (BI), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Western Blotting (WB)
(3), (2), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
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Quantity 50 μg
Shipping to United States ( )
Immunogen Human SMN aa. 14-174
Clone 8-SMN
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus), Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Alexa Fluor is a registered trademark of Molecular Probes, Inc., Eugene, OR.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SMN (SNRPN Antibody Abstract)
Background SMN (survival motor neuron) was discovered as a candidate gene, located in chromosome 5q13, for the fatal autosomal Spinal muscular atrophy (SMA) disorder. The SMN gene was missing or interrupted in a significant number of patients with SMA. The SMN protein is 294 amino acids and migrates with apparent molecular weight of 40 kDa. In addition to the cytoplasm, other studies localized SMN in dots of 0.1-1.0 µm within the nucleus. These novel nuclear structures were named gems and found associated to coiled bodies. It was also found that SMN interacts with the RGG box of hnRNP U and fibrillarin. Therefore, the biochemical function of SMN may be in the regulation of mRNA metabolism.
Synonyms: Survival Motor Neuron
Molecular Weight 40 kDa

Related Products: ABIN968587, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.
Supplier Images
Western Blotting (WB) image for anti-Small Nuclear Ribonucleoprotein N (SNRPN) (AA 14-174) antibody (ABIN968085) Western blot analysis of SMN on a HepG2 cell lysate (Human hepatocellular carcinoma, ...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Small Nuclear Ribonucleoprotein N (SNRPN) (AA 14-174) antibody (ABIN968085) Immunohistochemical staining of pyrimidal cells in a rat cortex, formalin-fixed paraf...
Immunofluorescence (IF) image for anti-Small Nuclear Ribonucleoprotein N (SNRPN) (AA 14-174) antibody (ABIN968085) Immunofluorescent staining of differentiated SH-SY5Y cells (right). Cells were seeded...
Product cited in: Côté, Boisvert, Boulanger et al.: "Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 274-87, 2003 (PubMed).

Claus, Doring, Gringel et al.: "Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 479-85, 2002 (PubMed).

Wang, Reddy, Shen: "Higher order arrangement of the eukaryotic nuclear bodies." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 21, pp. 13583-8, 2002 (PubMed).

Cifuentes-Diaz, Frugier, Tiziano et al.: "Deletion of murine SMN exon 7 directed to skeletal muscle leads to severe muscular dystrophy." in: The Journal of cell biology, Vol. 152, Issue 5, pp. 1107-14, 2001 (PubMed).

Background publications Lefebvre, Bürglen, Reboullet et al.: "Identification and characterization of a spinal muscular atrophy-determining gene." in: Cell, Vol. 80, Issue 1, pp. 155-65, 1995 (PubMed).

Catalog No. ABIN968085
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