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Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 461-574) antibody

Details for Product No. ABIN968356
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Antigen
Synonyms ARNT, zgc:136664, arnt1, hif1b, tango, xArnt, hif1beta, hif-1beta, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, D3Ertd557e, Drnt, ESTM42, Hif1b, W08714, mKIAA4051, Arnt1
Epitope
AA 461-574
(11), (7), (5), (5), (4), (4), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(84), (41), (36), (23), (13), (12), (11), (11), (1), (1)
Host
Mouse
(51), (33), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(71), (31), (25), (21), (10), (10), (9), (5), (4), (1), (1), (1)
Pubmed 5 references available
Quantity 150 µg
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Catalog No. ABIN968356
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Immunogen Human HIF-1beta/ARNT1
Clone OPG-01
Isotype IgG1
Cross-Reactivity Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name HIF-1beta
Background The Ah-receptor (AHR) is a ligand activated transcription factor that mediates the biological effects of agonists. AHR dimerizes with a structurally related protein known as ARNT (arylhydrocarbon-receptor nuclear transducer). This heterodimer binds enhancer elements and induces the expression of target genes, specifically those involved in the metabolism of xenobiotics. ARNT1 and ARNT2 are members of the basic-helix-loop-helix-PAS family of heterodimeric transcription factors, which also includes AHR, hypoxia-inducible factor-1alpha (HIF-1alpha), and the Drosophila single-minded protein (Sim). While ARNT2 expression is limited to brain and kidney, ARNT1 exhibits ubiquitous expression. A targeted disruption of the Arnt locus in the mouse yields embryonic stem cells that fail to activate genes that normally respond to low oxygen tension. Arnt -/- embryos do not survive and show defective angiogenesis of the yolk sac and branchial arches, stunted development, and wasting. Thus, in addition to its regulation of xenobiotic metabolism genes, ARNT is thought to induce developmental gene expression resulting in vascularization of the developing embryo.
Molecular Weight 95 kDa
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 461-574) antibody Western blot analysis of HIF-1beta on Jurkat cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of anti-HIF-1beta antibody.
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 461-574) antibody (2) Immunofluorescent staining of A431 cells.
anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 461-574) antibody (3) anti-Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) (AA 461-574) antibody (Image 3)
Product cited in: Drutel, Kathmann, Heron et al.: "Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT)." in: Biochemical and biophysical research communications, Vol. 225, Issue 2, pp. 333-9, 1996 (PubMed).

Maltepe, Schmidt, Baunoch et al.: "Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT." in: Nature, Vol. 386, Issue 6623, pp. 403-7, 1997 (PubMed).

Jiang, Jiang, Zheng et al.: "Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 12, Issue 7, pp. 363-9, 2001 (PubMed).

Suzuki, Tomida, Tsuruo: "Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia." in: Oncogene, Vol. 20, Issue 41, pp. 5779-88, 2001 (PubMed).

Ambrosini, Nath, Sierra-Honigmann et al.: "Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1." in: The Journal of biological chemistry, Vol. 277, Issue 37, pp. 34601-9, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN968356
Contact our Customer Service for availability and price in your country.
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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