Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Sorting Nexin 2 antibody (AA 15-137)

SNX2 Reactivity: Human, Dog WB, IF Host: Mouse Monoclonal 13-SNX2 unconjugated
Catalog No. ABIN968465
  • Target See all Sorting Nexin 2 (SNX2) Antibodies
    Sorting Nexin 2 (SNX2)
    Binding Specificity
    • 11
    • 9
    • 7
    • 5
    • 3
    • 2
    • 1
    • 1
    AA 15-137
    Reactivity
    • 38
    • 8
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Dog
    Host
    • 37
    • 1
    Mouse
    Clonality
    • 38
    Monoclonal
    Conjugate
    • 18
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Sorting Nexin 2 antibody is un-conjugated
    Application
    • 29
    • 17
    • 6
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Dog (Canine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human SNX2 aa. 15-137
    Clone
    13-SNX2
    Isotype
    IgG1
    Top Product
    Discover our top product SNX2 Primary Antibody
  • Comment

    Related Products: ABIN968536, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Haft, de la Luz Sierra, Barr, Haft, Taylor: "Identification of a family of sorting nexin molecules and characterization of their association with receptors." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7278-87, (1998) (PubMed).

    Kurten, Cadena, Gill: "Enhanced degradation of EGF receptors by a sorting nexin, SNX1." in: Science (New York, N.Y.), Vol. 272, Issue 5264, pp. 1008-10, (1996) (PubMed).

  • Target
    Sorting Nexin 2 (SNX2)
    Alternative Name
    SNX2 (SNX2 Products)
    Synonyms
    snx2 antibody, MGC64590 antibody, SNX2 antibody, LOC100219194 antibody, TRG-9 antibody, 0610030A03Rik antibody, zgc:123293 antibody, sorting nexin 2 S homeolog antibody, sorting nexin 2 antibody, snx2.S antibody, SNX2 antibody, BACOIKO006_25 antibody, snx2 antibody, Snx2 antibody
    Background
    Biological processes such as transmembrane signaling and receptor mediated endocytosis revolve around the function of cell surface receptors. A network of molecular machinery directs the intracellular trafficking of receptors during their biosynthesis and mediates signaling downstream of receptors. The sorting nexins (SNX1, SNX1A, SNX2, SNX3, and SNX4) are a family of intracellular proteins that are thought to direct the sorting of receptor proteins. The SNX proteins contain a conserved 100 amino acid region termed the phox homology (PX) domain and are part of a family of hydrophilic proteins which includes S. cerevisiae proteins that function in protein sorting. SNX1, SNX2, and SNX4 associate predominantly with membranes and bind transmembrane receptors such as those for EGF, PDGF, and insulin. SNX1 directs the EGF receptor to the lysosomes for degradation. SNX2 forms homomeric complexes and heteromeric complexes with SNX1, SNX1A, and SNX4. These complexes are thought to be necessary for efficient protein sorting. Thus, SNX2 and other sorting nexins are thought to play important roles in the specificity of protein trafficking to and from the plasma membrane. This antibody is routinely tested by western blot analysis.
    Synonyms: Sorting Nexin-2
    Molecular Weight
    72 kDa
You are here:
Support