Sorting Nexin 2 (SNX2) (AA 15-137) antibody

Details for Product No. ABIN968465
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Antigen
Synonyms snx2, MGC64590, SNX2, LOC100219194, TRG-9, 0610030A03Rik, zgc:123293
Epitope
AA 15-137
(11), (8), (2), (2), (2), (1)
Reactivity
Human
(29), (14), (13), (13), (12), (12), (1), (1)
Host
Mouse
(29)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunofluorescence (IF)
(20), (10), (8), (7)
Pubmed 2 references available
Quantity 50 µg
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Catalog No. ABIN968465
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Immunogen Human SNX2
Clone 7H3
Isotype IgG1
Cross-Reactivity Dog (Canine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name SNX2
Background Biological processes such as transmembrane signaling and receptor mediated endocytosis revolve around the function of cell surface receptors. A network of molecular machinery directs the intracellular trafficking of receptors during their biosynthesis and mediates signaling downstream of receptors. The sorting nexins (SNX1, SNX1A, SNX2, SNX3, and SNX4) are a family of intracellular proteins that are thought to direct the sorting of receptor proteins. The SNX proteins contain a conserved 100 amino acid region termed the phox homology (PX) domain and are part of a family of hydrophilic proteins which includes S. cerevisiae proteins that function in protein sorting. SNX1, SNX2, and SNX4 associate predominantly with membranes and bind transmembrane receptors such as those for EGF, PDGF, and insulin. SNX1 directs the EGF receptor to the lysosomes for degradation. SNX2 forms homomeric complexes and heteromeric complexes with SNX1, SNX1A, and SNX4. These complexes are thought to be necessary for efficient protein sorting. Thus, SNX2 and other sorting nexins are thought to play important roles in the specificity of protein trafficking to and from the plasma membrane. This antibody is routinely tested by western blot analysis.
Synonyms: Sorting Nexin-2
Molecular Weight 72 kDa
Research Area Signaling
Comment

Related Products: ABIN968536, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Sorting Nexin 2 (SNX2) (AA 15-137) antibody Immunofluorescence staining of ES-2 cells (Human ovary clear cell carcinoma, ATCC CRL-1978).
anti-Sorting Nexin 2 (SNX2) (AA 15-137) antibody (2) Western blot analysis of SNX2 on a human endothelial cell lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1: 2000 dilution of the mouse anti- SNX2 antibody.
anti-Sorting Nexin 2 (SNX2) (AA 15-137) antibody (3) anti-Sorting Nexin 2 (SNX2) (AA 15-137) antibody (Image 3)
Product cited in: Kurten, Cadena, Gill: "Enhanced degradation of EGF receptors by a sorting nexin, SNX1." in: Science (New York, N.Y.), Vol. 272, Issue 5264, pp. 1008-10, 1996 (PubMed).

Haft, de la Luz Sierra, Barr et al.: "Identification of a family of sorting nexin molecules and characterization of their association with receptors." in: Molecular and cellular biology, Vol. 18, Issue 12, pp. 7278-87, 1998 (PubMed).

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