Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 114-220) antibody

Details for Product No. ABIN968602
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Antigen
Synonyms
LOC100101896, MNSOD, GB14346, sod2, MGC88869, Sod2, CG8905, Dmel\\CG8905, Mito SOD, Mn SOD, Mn-SOD, Mn-SOD2, MnSOD, MnSODII, Mn[2+]SOD, SOD, SOD-2, SOD2, Sod-2, dSOD2, mitSOD2, mnSOD, IPOB, MVCD6, cb4 ... show more
LOC100101896, MNSOD, GB14346, sod2, MGC88869, Sod2, CG8905, Dmel\\CG8905, Mito SOD, Mn SOD, Mn-SOD, Mn-SOD2, MnSOD, MnSODII, Mn[2+]SOD, SOD, SOD-2, SOD2, Sod-2, dSOD2, mitSOD2, mnSOD, IPOB, MVCD6, cb463, wu:fj33b01, zgc:73051 show less
Epitope
AA 114-220
(10), (7), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(134), (68), (43), (24), (23), (22), (14), (14), (12), (10), (10), (10), (10), (7), (5), (4), (2), (2), (1), (1), (1)
Host
Mouse
(109), (45), (10), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (7), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(147), (88), (73), (68), (33), (23), (15), (13), (10), (4), (2), (1)
Pubmed 5 references available
Quantity 50 μg
Options
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Catalog No. ABIN968602
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Immunogen Mouse MnSOD
Clone Hs-3
Isotype IgG1
Cross-Reactivity Human, Dog (Canine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Alternative Name MnSOD
Background Superoxide dismutase (SOD), catalase, and glutathione peroxidase are necessary for preventing the intracellular accumulation of reactive oxygen species. Three forms of SOD include the cytosolic Cu/Zn2+ SOD, the extracelluar Cu/Zn[2+] SOD, and the mitochondrial manganese (Mn) superoxide dismutase (MnSOD). In the mitochondria, MnSOD catalyzes the dismutation of two superoxide radicals, producing H2O2 and oxygen. Following protein synthesis, MnSOD is post-transcriptionally modified for transport from the cytosol into the mitochondria. In rat hepatocytes, H2O2 exposure induces MnSOD expression, while in rat lung, exposure to smoke induces expression in bronchial epithelial cells. In addition, MnSOD expression is required for PC12 cell resistance to nitric oxide (NO) toxicity and for nNOS neuron resistance to NMDA-induced NO toxicity. Superoxide radical anions may induce transcriptional activation of the MnSOD gene through PKC phosphorylation and activation of a CREB-1/ATF-1-like factor. Thus, MnSOD removal of reactive oxygen species created by exposure to toxic stimuli is thought to be critical for the survival of a variety of cell types. This antibody is routinely tested by western blot analysis.
Synonyms: Manganese Superoxide Dismutase
Molecular Weight 25 kDa
Comment

Related Products: ABIN968542, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Superoxide Dismutase 2, Mitochondrial (SOD2) (AA 114-220) antibody Western blot analysis of MnSOD on a mouse kidney lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1: 4000 dilution of the mouse anti- MnSOD antibody.
Product cited in: Gilks, Price, Wright et al.: "Antioxidant gene expression in rat lung after exposure to cigarette smoke." in: The American journal of pathology, Vol. 152, Issue 1, pp. 269-78, 1998 (PubMed).

Röhrdanz, Kahl: "Alterations of antioxidant enzyme expression in response to hydrogen peroxide." in: Free radical biology & medicine, Vol. 24, Issue 1, pp. 27-38, 1998 (PubMed).

Gonzalez-Zulueta, Ensz, Mukhina et al.: "Manganese superoxide dismutase protects nNOS neurons from NMDA and nitric oxide-mediated neurotoxicity." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 6, pp. 2040-55, 1998 (PubMed).

Ambrosone, Freudenheim, Thompson et al.: "Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer." in: Cancer research, Vol. 59, Issue 3, pp. 602-6, 1999 (PubMed).

Kim, Roe, Chock et al.: "Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate." in: The Journal of biological chemistry, Vol. 274, Issue 52, pp. 37455-60, 2000 (PubMed).

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