Serine Racemase (SRR) (AA 127-248) antibody

Details for Product No. ABIN968727
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Antigen
Synonyms Srs, ILV1, ISO1, DDBDRAFT_0188432, DDBDRAFT_0230209, DDB_0188432, DDB_0230209, ilv1, iso1
Epitope
AA 127-248
(3), (1), (1)
Reactivity
Mouse (Murine)
(34), (12), (12), (12), (12), (1)
Host
Mouse
(20), (16)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(25), (15), (10), (9), (8), (8), (3), (3), (2), (1)
Pubmed 2 references available
Catalog no. ABIN968727
Quantity 150 µg
Price
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Immunogen Mouse serine racemase
Clone OPG-01
Isotype IgG1
Cross-Reactivity Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Serine Racemase
Background The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. NMDA receptors require coactivation at both glutamate and glycine sites. D-serine is a D-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on NMDA receptors. D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5' phosphate (PLP)-dependent enzyme family. Serine racemase mRNA is expressed in brain and liver, and serine racemase protein is expressed in glial cells. Degradation of D-serine by D-amino acid oxidase attenuates NMDA receptor-mediated calcium influx, and implicates D-serine as an endogenouse modulator of NMDA receptor function. Thus, glial cell production of D-serine via serine racemase activity may be an important system for modulation of synaptic transmission. This antibody is routinely tested by western blot analysis.
Molecular Weight 38 kDa
Comment

Related Products: ABIN968540, ABIN967389

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Serine Racemase (SRR) (AA 127-248) antibody Western blot analysis of serine racemase in a mouse cerebrum lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the anti- serine racemase antibody.
Product cited in: Wolosker, Blackshaw, Snyder: "Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13409-14, 1999 (PubMed).

Mothet, Parent, Wolosker et al.: "D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 9, pp. 4926-31, 2000 (PubMed).

Hosts (20), (16)
Reactivities (34), (12), (12), (12), (12), (1)
Applications (25), (15), (10), (9), (8), (8), (3), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
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