Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Add to Basket
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN968805

Nicastrin (NCSTN) (AA 168-289) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms APH2, Nct, Aph2, AA727311, D1Dau13e, Kiaa0253, mKIAA0253, 9430068N19Rik, CG7012, Dmel\\CG7012, Nic, S5A, ST96B, agro, dNct, nic, NCSTN, DKFZp469O2418
Epitope
»Alternatives AA 168-289
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN968805
Quantity 50 µg
Price
Contact our Customer Service for availability and price in your country.
Shipping to
Immunogen Human Nicastrin
Clone G52C7-1
Isotype IgG2a
Cross-Reactivity Chicken, Dog (Canine), Mouse (Murine), Rat (Rattus)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Purification Purified from tissue culture supernatant or ascites by affinity chromatography.
Purity Purified
Alternative Name Nicastrin
Background Amyloid precursor protein (APP) gene encodes multiple APPs ranging from 695 to 770 amino acids. The unprocessed form of APP is a putative cell surface receptor that possesses neurite-promoting activity, and is involved in synaptic vesicle recycling. Processing of APP by sequential enzymatic activity of beta- and gamma-secretase, and the presenilin proteins PS1 and PS2, produces APP fragments that may have unique functions. beta-secretase activity cleaves the extracellular portion of APP leading to asecreted APP form, while gamma-secretase activity produces beta-Amyloid peptide (39-43 amino acids). The Abeta peptide produces abnormal plaques in the cerebral cortex and blood vesselwalls during Alzheimer's disease. Nicastrin is a PS1 associated transmembrane protein,that contains N-terminal glycosylation and myristoylation sites. Nicastrin can bind full length APP and the fragments produced by gamma-secretase. In C. elegans, suppression of nicastrin expression produces phenotypes that mimic those produced when notch signaling proteins are suppressed. In Drosophila, deficiencies in nicastrin prevent cleavage of the intracellular portion of Notch. Thus, nicastrin may be a functional component of presenilins and gamma-secretase complexes, which process Notch and APP transmembrane receptors.
Molecular Weight 110 kDa
Research Area Stem Cells, Alzheimer's Disease, Immunology
Comment

Related Products: ABIN967389, ABIN968553

Restrictions For Research Use only
Format Liquid
Concentration 250 µg/ml
Buffer Aqueous buffered solution containing BSA, glycerol.
Preservative Sodium azide
Storage -20 °C
Product cited in: Yu, Nishimura, Arawaka et al.: "Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing." in: Nature, Vol. 407, Issue 6800, pp. 48-54, 2000 (PubMed).

Chen, Yu, Arawaka et al.: "Nicastrin binds to membrane-tethered Notch." in: Nature cell biology, Vol. 3, Issue 8, pp. 751-4, 2001 (PubMed).

Alternatives for antigen "Nicastrin (NCSTN)", type "Antibodies"
Hosts (60), (15), (1)
Reactivities (78), (50), (46), (17), (17), (17)
Applications (59), (38), (17), (16), (16), (10), (2), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1)
Beacon