Nicastrin antibody (AA 99-133)

Catalog No. ABIN6242494

Product Details anti-Nicastrin Antibody

Target: Nicastrin (NCSTN)

Binding Specificity: AA 99-133

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Nicastrin antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NCSTN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 99-133 amino acids from human NCSTN.

Clone: RB53031

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:8000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for Nicastrin

Target: Nicastrin (NCSTN)

Alternative Name: NCSTN (NCSTN Products)

Synonyms: CG7012 antibody, Dmel\\CG7012 antibody, Nct antibody, Nic antibody, S5A antibody, ST96B antibody, agro antibody, dNct antibody, nic antibody, NCSTN antibody, DKFZp469O2418 antibody, APH2 antibody, 9430068N19Rik antibody, AA727311 antibody, Aph2 antibody, D1Dau13e antibody, Kiaa0253 antibody, mKIAA0253 antibody, nicastrin antibody, Nicastrin antibody, NCSTN antibody, nct antibody, ncstn antibody, CpipJ_CPIJ001617 antibody, Ncstn antibody, aph-2 antibody

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta- amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.

Molecular Weight: 78411

UniProt: Q92542

Pathways: Notch Signaling, Neurotrophin Signaling Pathway