Cyclin-Dependent Kinase 9 (CDK9) antibody

Details for Product No. ABIN969043
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Antigen
Synonyms CDK9, CG5179, Dmel\\CG5179, P-TEF, P-TEFb, PTefb, cdk9, c-2k, cdc2l4, ctk1, pitalre, tak, C-2k, CDC2L4, CTK1, PITALRE, TAK, wu:fb22e09, wu:fc06c02
Reactivity
Human
(109), (54), (51), (38), (38), (38), (26), (8), (2), (1), (1)
Host
Mouse
(89), (21)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(81), (47), (30), (26), (23), (15), (7), (5), (4), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 100 μL
Options
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Catalog No. ABIN969043
396.00 $
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Immunogen Purified recombinant fragment of human CDK9 expressed in E. coli.
Clone 1B5D10
Isotype IgG1
Purification Ascites
Alternative Name CDK9
Background Synonyms:
TAK, C-2k, CTK1, CDC2L4, PITALRE
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. (provided by RefSeq) Tissue specificity: Ubiquitous.
Molecular Weight 43 kDa
Gene ID 1025
Research Area Cell Cycle
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Cyclin-Dependent Kinase 9 (CDK9) antibody Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng)
anti-Cyclin-Dependent Kinase 9 (CDK9) antibody (2) Figure 2: Immunohistochemical analysis of paraffin-embedded endometrial cancer tissues (left) and rectum cancer tissues (right) using CDK9 mouse mAb with DAB staining.
anti-Cyclin-Dependent Kinase 9 (CDK9) antibody (3) Figure 1: Western blot analysis using CDK9 mouse mAb against Jurkat (1), A431 (2) and HEK293 (3) cell lysate.
Product cited in: Montanuy, Torremocha, Hernández-Munain et al.: "Promoter influences transcription elongation: TATA-box element mediates the assembly of processive transcription complexes responsive to cyclin-dependent kinase 9." in: The Journal of biological chemistry, Vol. 283, Issue 12, pp. 7368-78, 2008 (PubMed).

Sabò, Lusic, Cereseto et al.: "Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2201-12, 2008 (PubMed).

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