CRTC2 antibody

Catalog No. ABIN969067

This Mouse Monoclonal antibody specifically detects CRTC2 in WB, ELISA, IHC, FACS and ICC. It exhibits reactivity toward Human and Monkey and has been mentioned in 3+ publications.

Quick Overview for CRTC2 antibody (ABIN969067)

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Reactivity: Human, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This CRTC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 5B10

Product Details anti-CRTC2 Antibody

Purpose: CRTC2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CRTC2 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CRTC2 antibody (ABIN969067)

Murata, Sato, Nakayama, Kudoh, Iwahori, Isomura, Tajima, Hishiki, Ohshima, Hijikata, Shimotohno, Tsurumi: "TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 protein." in: The Journal of biological chemistry, Vol. 284, Issue 12, pp. 8033-41, (2009) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Dentin, Liu, Koo, Hedrick, Vargas, Heredia, Yates, Montminy: "Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2." in: Nature, Vol. 449, Issue 7160, pp. 366-9, (2007) (PubMed).

Target Details for CRTC2

Target: CRTC2 (CREB Regulated Transcription Coactivator 2 (CRTC2))

Alternative Name: CRTC2

Background: Glucose homeostasis is regulated by hormones and cellular energy status. Elevations of blood glucose during feeding stimulate insulin release from pancreatic

Molecular Weight: 80 kDa

UniProt: Q53ET0

Pathways: AMPK Signaling, Carbohydrate Homeostasis