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Janus Kinase 2 (JAK2) (AA 745-955) antibody

Antigen

Janus Kinase 2 (JAK2)
Synonyms JTK10, Fd17, C81284, AI504024, JAK2, DKFZp469G074
Binding Site
Alternatives

AA 745-955
Clonality Monoclonal (1C1)
Host
Alternatives

Mouse
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives ELISA, Western Blotting (WB)
2 references available
Catalog no. ABIN969223
Quantity 0.1ml  (Variants)
Price 363.00 $   Plus shipping costs $45.00
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Additional Information
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Alternative name JAK2
Gene ID 3717
Immunogen Purified recombinant fragment of JAK2 (AA 745-955) expressed in E. Coli.
Format Liquid
Isotype IgG1
Clone 1C1
Description This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
Synonyms: JTK10, JAK2
Molecular Weight 130.6kDa

Application Details
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Application Notes Western Blotting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Purification Ascites
Buffer Ascitic fluid containing 0.03% sodium azide.
Preservative 0.03% sodium azide
Storage Store at 4℃, for long term storage, store at -20℃.
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Restrictions For Research Use only

Publications
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Product Pezet, Buteau, Kelly et al.: "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor." in: Molecular and cellular endocrinology, Vol. 129, Issue 2, pp. 199-208, 1997 (PubMed).

Pollack, Kotenko, He et al.: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999 (PubMed).

Alternatives
Application Details Publications Variants back to top

Alternatives for antigen "Janus Kinase 2 (JAK2)", type "Antibodies"
Hosts Rabbit (90), Mouse (5), Goat (1)
Reactivities Human (85), Rat (Rattus) (73), Mouse (Murine) (64), Chicken (28), Pig (Porcine) (28), Cow (Bovine) (18), Dog (Canine) (18), Zebrafish (10)
Applications Western Blotting (WB) (44), Immunohistochemistry (IHC) (35), ELISA (32), Immunofluorescence (IF) (28), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (11), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunocytochemistry (ICC) (2), Immunoprecipitation (IP) (2), Immunoelectron Microscopy (IEM) (1)
Conjugates Biotin (4), Alexa Fluor 350 (3), Alexa Fluor 488 (3), Alexa Fluor 555 (3), Alexa Fluor 647 (3), PE,Cy5.5 (3), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy7 (1)
Epitopes pTyr221 (8), pTyr1007 (7), pTyr1008,pTyr1007 (4), Tyr1007 (2), pTyr211 (2), AA 745-955 (1), C-Term (1), Center (1), pTyr1007, pTyr1008 (1), pTyr570 (1), pTyr654,pTyr653 (1), pTyr931 (1)