Janus Kinase 2 (JAK2) (AA 745-955) antibody

Details for Product No. ABIN969223
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Antigen
Synonyms JAK2bCA, jak2, JTK10, THCYT3, AI504024, C81284, Fd17, JAK-2
Epitope
AA 745-955
(35), (28), (15), (13), (11), (10), (8), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(192), (157), (151), (38), (25), (24), (12), (2), (2), (1), (1)
Host
Mouse
(195), (10), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(8), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (1), (1)
Application
ELISA, Western Blotting (WB)
(134), (87), (83), (30), (30), (18), (15), (11), (4), (3), (2)
Pubmed 2 references available
Quantity 100 μL
Options
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Catalog No. ABIN969223
363.00 $
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Immunogen Purified recombinant fragment of JAK2 (745-955AA ) expressed in E. coli.
Clone 1C1
Isotype IgG1
Purification Ascites
Alternative Name JAK2
Background Synonyms:
JTK10, JAK2
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to γ interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
Molecular Weight 130.6 kDa
Gene ID 3717
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-Janus Kinase 2 (JAK2) (AA 745-955) antibody Figure 1: Western blot analysis using JAK2 mouse mAb against THP-1 (1) cell lysate.
Product cited in: Pezet, Buteau, Kelly et al.: "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor." in: Molecular and cellular endocrinology, Vol. 129, Issue 2, pp. 199-208, 1997 (PubMed).

Pollack, Kotenko, He et al.: "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity." in: The Journal of biological chemistry, Vol. 274, Issue 44, pp. 31531-42, 1999 (PubMed).

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