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KDM3A antibody (Lysine (K)-Specific Demethylase 3A)

Details for Product anti-KDM3A Antibody No. ABIN969228, Supplier: Log in to see
Antigen
  • tsga
  • jmjd1
  • jhdm2a
  • jhmd2a
  • jmjd1a
  • KDM3A
  • JMJD1A
  • kdm3a
  • JHDM2A
  • JHMD2A
  • JMJD1
  • TSGA
  • 1700105C21Rik
  • C230043E16Rik
  • JHDM2a
  • Jmjd1
  • Jmjd1a
  • KDM2A
  • TGSA
  • Tsga
  • mKIAA0742
  • lysine (K)-specific demethylase 3B
  • lysine (K)-specific demethylase 3A
  • jumonji domain containing 1A
  • Kdm3b
  • kdm3a
  • KDM3A
  • LOC100224407
  • LOC100226356
  • kdm3a-b
  • Kdm3a
Alternatives
anti-Human KDM3A antibody for Immunohistochemistry
Reactivity
Human
130
55
31
13
5
4
3
1
1
1
1
1
1
1
1
Host
Mouse
88
42
Clonality (Clone)
Monoclonal ()
Conjugate
This KDM3A antibody is un-conjugated
5
5
4
4
4
4
3
3
3
3
3
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
123
70
66
52
45
43
7
4
2
2
2
1
Options
Supplier
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Immunogen Purified recombinant fragment of human KDM3A expressed in E. coli.
Clone 1-00E-12
Isotype IgG1
Purification Ascites
Alternative Name KDM3A (KDM3A Antibody Abstract)
Background This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and α-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
Molecular Weight 147 kDa
Gene ID 55818
HGNC 55818
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Immunohistochemistry (IHC) image for anti-KDM3A antibody (Lysine (K)-Specific Demethylase 3A) (ABIN969228) Figure 1: Immunohistochemical analysis of paraffin-embedded colonic cancer tissues (l...
Western Blotting (WB) image for anti-KDM3A antibody (Lysine (K)-Specific Demethylase 3A) (ABIN969228) Figure 2: Western blot analysis using KDM3A mouse mAb against Hela (1) and HepG2 (2) ...
Product cited in: Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, 2005 (PubMed).

Nagase, Ishikawa, Suyama, Kikuno, Miyajima, Tanaka, Kotani, Nomura, Ohara: "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 5, pp. 277-86, 1999 (PubMed).

Background publications Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, 2004 (PubMed).