KSHVORF45 antibody
-
- Target
- KSHVORF45
- Reactivity
- Human Herpesvirus 8 (HHV-8)
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
- Application
- ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of KSHV ORF45 expressed in E. coli.
- Clone
- 2D4A5
- Isotype
- IgG1
-
-
- Application Notes
- ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
-
-
Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury." in: Anesthesiology, Vol. 99, Issue 5, pp. 1175-9, (2003) (PubMed).
: "The ORF45 protein of Kaposi's sarcoma-associated herpesvirus is associated with purified virions." in: Journal of virology, Vol. 77, Issue 7, pp. 4221-30, (2003) (PubMed).
: "A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 8, pp. 5573-8, (2002) (PubMed).
: "
-
Cyclooxygenase-1 in the spinal cord is altered after peripheral nerve injury." in: Anesthesiology, Vol. 99, Issue 5, pp. 1175-9, (2003) (PubMed).
-
- Target
- KSHVORF45
- Target Type
- Viral Protein
- Background
-
Description: Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi's sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman's disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
Aliases: ORF45
- Gene ID
- 4961474
- HGNC
- 4961474
-