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Details for Product No. ABIN969405

SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

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Synonyms madh6, smad6, wu:fb22g05, Smad6-like, AOVD2, HsT17432, MADH6, MADH7, Madh6, b2b390Clo, madh7, Xsmad6, hst17432
»Alternatives Human
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives ELISA, Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN969405
Quantity 100 µL
363.00 $   Plus shipping costs $45.00
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Immunogen Purified recombinant fragment of human SMAD6 expressed in E. coli.
Clone 5H3
Isotype IgG1
Purification Ascites
Alternative Name SMAD6
Background Synonyms:
MADH6, MADH7, HsT17432, SMAD6
Antagonist of signaling by TGF-β (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Molecular Weight 53 kDa
Gene ID 4091
Research Area Cardiovascular, Hypertrophy, Cardiogenesis, Signaling, Transcription Factors
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Shen, Chen, Wang et al.: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, 2006 (PubMed).

Alternatives for antigen "SMAD, Mothers Against DPP Homolog 6 (SMAD6)", type "Antibodies"
Hosts (30), (27)
Reactivities (57), (11), (5), (3), (1), (1), (1), (1)
Applications (56), (31), (21), (7), (7), (3), (1), (1)
Epitopes (8), (7), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)