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SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

Details for Product No. ABIN969405
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Antigen
Synonyms madh6, madh7, Xsmad6, hst17432, AOVD2, HsT17432, MADH6, MADH7, Madh6, b2b390Clo, Smad6-like, smad6, wu:fb22g05
Reactivity
Human
(71), (20), (5), (2), (1), (1), (1), (1)
Host
Mouse
(52), (30)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
ELISA, Western Blotting (WB)
(81), (47), (24), (14), (11), (4), (4), (3), (2)
Pubmed 1 reference available
Quantity 100 µL
Options
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Catalog No. ABIN969405
363.00 $
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Immunogen Purified recombinant fragment of human SMAD6 expressed in E. coli.
Clone 5H3
Isotype IgG1
Purification Ascites
Alternative Name SMAD6
Background Synonyms:
MADH6, MADH7, HsT17432, SMAD6
Antagonist of signaling by TGF-β (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Molecular Weight 53 kDa
Gene ID 4091
Research Area Cardiovascular, Hypertrophy, Cardiogenesis, Signaling, Transcription Factors
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody Figure 1: Western blot analysis using SMAD6 mouse mAb against A431 (1), A431 (2), Hela (3) and Jurkat (4) cell lysate.
Product cited in: Shen, Chen, Wang et al.: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, 2006 (PubMed).

Validation Images
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