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SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

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Synonyms madh6, madh7, Xsmad6, hst17432, AOVD2, HsT17432, MADH6, MADH7, Madh6, b2b390Clo, Smad6-like, smad6, wu:fb22g05
(118), (34), (11), (2), (2), (1), (1), (1), (1)
(95), (47)
Clonality (Clone)
Monoclonal ()
(4), (4), (4), (4), (4), (4)
ELISA, Western Blotting (WB)
(129), (79), (29), (26), (23), (6), (4), (3), (2), (2)
Pubmed 3 references available
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Quantity 100 μL
Shipping to United States ( )
Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human SMAD6 expressed in E. coli.
Clone 5H3
Isotype IgG1
Purification Ascites
Alternative Name SMAD6 (SMAD6 Antibody Abstract)
Background Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Molecular Weight 53 kDa
Gene ID 4091
HGNC 4091
Research Area Cardiovascular, Hypertrophy, Cardiogenesis, Signaling, Transcription Factors
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Western Blotting (WB) image for anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody (ABIN969405) Figure 1: Western blot analysis using SMAD6 mouse mAb against A431 (1), A431 (2), Hel...
Product cited in: Shintani, Yagi, Nakayama et al.: "A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension." in: Journal of medical genetics, Vol. 46, Issue 5, pp. 331-7, 2009 (PubMed).

Choi, Lee, Lim et al.: "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1." in: Nature immunology, Vol. 7, Issue 10, pp. 1057-65, 2006 (PubMed).

Shen, Chen, Wang et al.: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, 2006 (PubMed).

Catalog No. ABIN969405
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