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SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody

Details for Product No. ABIN969405, Supplier: Log in to see
Antigen
  • madh6
  • madh7
  • Xsmad6
  • hst17432
  • AOVD2
  • HsT17432
  • MADH6
  • MADH7
  • Madh6
  • b2b390Clo
  • Smad6-like
  • smad6
  • wu:fb22g05
Reactivity
Human
115
34
11
2
2
1
1
1
1
Host
Mouse
92
47
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
4
4
4
4
Application
ELISA, Western Blotting (WB)
126
79
28
26
23
6
4
3
2
2
Supplier
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Immunogen Purified recombinant fragment of human SMAD6 expressed in E. coli.
Clone 5H3
Isotype IgG1
Purification Ascites
Alternative Name SMAD6 (SMAD6 Antibody Abstract)
Background Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members, has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Molecular Weight 53 kDa
Gene ID 4091
HGNC 4091
Research Area Cardiovascular, Hypertrophy, Cardiogenesis, Signaling, Transcription Factors
Pathways
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Supplier Images
Western Blotting (WB) image for anti-SMAD, Mothers Against DPP Homolog 6 (SMAD6) antibody (ABIN969405) Figure 1: Western blot analysis using SMAD6 mouse mAb against A431 (1), A431 (2), Hel...
Product cited in: Shintani, Yagi, Nakayama et al.: "A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension." in: Journal of medical genetics, Vol. 46, Issue 5, pp. 331-7, 2009 (PubMed).

Choi, Lee, Lim et al.: "Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1." in: Nature immunology, Vol. 7, Issue 10, pp. 1057-65, 2006 (PubMed).

Shen, Chen, Wang et al.: "Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation." in: The Journal of biological chemistry, Vol. 281, Issue 6, pp. 3569-76, 2006 (PubMed).