WDR5 antibody

Catalog No. ABIN969456

This anti-WDR5 antibody is a Mouse Monoclonal antibody detecting WDR5 in WB and ELISA. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for WDR5 antibody (ABIN969456)

Target: WDR5 (WD Repeat Domain 5 (WDR5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This WDR5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 7B11

Product Details anti-WDR5 Antibody

Purpose: WDR5 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human WDR5 expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-WDR5 antibody (ABIN969456)

Patel, Vought, Dharmarajan, Cosgrove: "A conserved arginine-containing motif crucial for the assembly and enzymatic activity of the mixed lineage leukemia protein-1 core complex." in: The Journal of biological chemistry, Vol. 283, Issue 47, pp. 32162-75, (2008) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Target Details for WDR5

Target: WDR5 (WD Repeat Domain 5 (WDR5))

Alternative Name: WDR5

Background: WD-repeat protein 5 (WDR5, also designated BMP-2-induced gene 3 kb or BIG-3) belongs to the family of WD-40 repeat proteins, and is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. WDR5 is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes that selectively binds to dimethylated Lys4 (K4me2) in Histone H3 to promote K4 trimethylation by TRX. It is expressed in osteoblasts, chondrocytes, osteocytes and marrow stromal cells. The WDR5 protein contains 7 WD-repeats, which may play a role in its function of accelerating osteoblast differentiation.

Molecular Weight: 36.6 kDa

UniProt: P61964