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|Application / Reactivity||Human|
|Dot Blot (DB)||45 Antibodies|
|Enzyme Immunoassay (EIA)||6 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||17 Antibodies|
|Immunofluorescence (IF)||59 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||169 Antibodies|
|Immunohistochemistry (IHC)||150 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||87 Antibodies|
|Immunoprecipitation (IP)||18 Antibodies|
|Proximity Ligation Assay (PLA)||2 Antibodies|
|Western Blotting (WB)||322 Antibodies|
|Antigen||C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) Antibodies|
|Conjugate||This ABL1 antibody is un-conjugated Alternatives|
Dot Blot (DB), Immunofluorescence (IF)
|5 references available|
|Supplier||Log in to see|
Product Details anti-ABL1 AntibodyTarget Details ABL1 Application Details Handling References for anti-ABL1 Antibody (ABIN389865) Images
|Specificity||This Phospho-ABL-Y204 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y204 of human ABL.|
|Predicted Reactivity||Mouse (Murine)|
|Purification||This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Immunogen||This ABL Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y204 of human ABL.|
Target Details ABL1Product Details anti-ABL1 Antibody Application Details Handling References for anti-ABL1 Antibody (ABIN389865) Images back to top
|Alternative Name||ABL (ABL1 Antibody Abstract)|
ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Synonyms: Proto-oncogene tyrosine-protein kinase ABL1, p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1, ABL1, ABL, JTK7
|Molecular Weight||122873 DA|
|Research Area||Apoptosis/Necrosis, Cancer, Cell Cycle, Phospho-specific antibodies, Cell Structure|
Application DetailsProduct Details anti-ABL1 Antibody Target Details ABL1 Handling References for anti-ABL1 Antibody (ABIN389865) Images back to top
|Application Notes||DB = 1:500, IF = 1:10-50|
|Restrictions||For Research Use only|
HandlingProduct Details anti-ABL1 Antibody Target Details ABL1 Application Details References for anti-ABL1 Antibody (ABIN389865) Images back to top
|Buffer||PBS with 0.09 % (W/V) sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.|
|Expiry Date||6 months|
References for anti-ABL1 Antibody (ABIN389865)Product Details anti-ABL1 Antibody Target Details ABL1 Application Details Handling Images back to top
Barnes, McIntosh, Whetton et al.: "Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation." in: Oncogene, Vol. 24, Issue 20, pp. 3257-67, 2005 (PubMed).
Kim, Cho, Yoon et al.: "Interpretation of submicroscopic deletions of the BCR or ABL gene should not depend on extra signal-FISH: problems in interpretation of submicroscopic deletion of the BCR or ABL gene with extra ..." in: Genes, chromosomes & cancer, Vol. 43, Issue 1, pp. 37-44, 2005 (PubMed).
Robinson, Martineau, Harris et al.: "Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 19, Issue 4, pp. 564-71, 2005 (PubMed).
Wei, Li, Liu: "Insights into selective activation of p53 DNA binding by c-Abl." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12271-8, 2005 (PubMed).
Aichberger, Mayerhofer, Krauth et al.: "Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides." in: Blood, Vol. 105, Issue 8, pp. 3303-11, 2005 (PubMed).
ImagesProduct Details anti-ABL1 Antibody Target Details ABL1 Application Details Handling References for anti-ABL1 Antibody (ABIN389865) back to top