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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||322 Antibodies||153 Antibodies||104 Antibodies|
|Proximity Ligation Assay (PLA)||2 Antibodies|
|Immunoprecipitation (IP)||18 Antibodies||6 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||87 Antibodies||54 Antibodies||48 Antibodies|
|Immunohistochemistry (IHC)||150 Antibodies||75 Antibodies||31 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||169 Antibodies||158 Antibodies||158 Antibodies|
|Antigen||C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This ABL1 antibody is un-conjugated Alternatives|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Product Details anti-ABL1 AntibodyTarget Details ABL1 Application Details Handling Images
|Specificity||This antibody detects endogenous levels of Abl1 protein when phosphorylated at Tyr204.|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|Purity||> 95 % by SDS-PAGE|
Target Details ABL1Product Details anti-ABL1 Antibody Application Details Handling Images back to top
|Alternative Name||ABL1 (ABL1 Antibody Abstract)|
|Background||The Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95 % of chronic myelocytic leukemia (CML), 20-25 % of adult acute lymphoblastic leukemia (ALL) and 2-5 % of pediatric ALL. In these leukemias the c-Abl protooncogene undergoes a (9,22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl proteintyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac.Synonyms: Abelson murine leukemia viral oncogene homolog 1, JTK7, Proto-oncogene tyrosine-protein kinase ABL1, bcr/abl, c-ABL, p150|
|Molecular Weight||approx. 123 kDa|
Application DetailsProduct Details anti-ABL1 Antibody Target Details ABL1 Handling Images back to top
Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-ABL1 Antibody Target Details ABL1 Application Details Images back to top
|Buffer||Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
ImagesProduct Details anti-ABL1 Antibody Target Details ABL1 Application Details Handling back to top