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anti-Human FADD antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended FADD Antibody (supplied by: Log in to see )

Antigen
Fas (TNFRSF6)-Associated Via Death Domain (FADD) Antibodies
  • MORT1
  • Mort1/FADD
  • Mort1
  • TNFRSF6
  • Fas (TNFRSF6)-associated via death domain
  • FADD
  • Fadd
Epitope
pSer194
30
27
25
20
19
17
14
9
7
6
5
3
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
211
78
38
11
3
2
Host
Rabbit
167
96
Clonality
Polyclonal
Conjugate
This FADD antibody is un-conjugated
11
10
9
7
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
232
144
87
39
29
15
14
7
5
4
4
3
1
1
Options
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Catalog No. ABIN713426
$ 317.90
Plus shipping costs $45.00

Similar anti-FADD Antibodies

Application / Reactivity Human
ELISA 119 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 5 Antibodies
Flow Cytometry (FACS) 4 Antibodies
Immunochromatography (IC) 4 Antibodies
Immunocytochemistry (ICC) 6 Antibodies
Immunofluorescence (IF) 15 Antibodies
Immunofluorescence (fixed cells) (IF/ICC) 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 1 Antibodies
Immunohistochemistry (IHC) 65 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 35 Antibodies
Immunoprecipitation (IP) 28 Antibodies
Proximity Ligation Assay (PLA) 1 Antibodies
Western Blotting (WB) 194 Antibodies

General

Antigen Fas (TNFRSF6)-Associated Via Death Domain (FADD) Antibodies
Epitope pSer194
(30), (27), (25), (20), (19), (17), (14), (9), (7), (6), (5), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(211), (78), (38), (11), (3), (2)
Host Rabbit
(167), (96)
Clonality
Polyclonal
Conjugate This FADD antibody is un-conjugated
(11), (10), (9), (7), (5), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(232), (144), (87), (39), (29), (15), (14), (7), (5), (4), (4), (3), (1), (1)
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Product Details anti-FADD Antibody

Target Details FADD Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human FADD around the phosphorylation site of Ser194
Isotype IgG

Target Details FADD

Product Details anti-FADD Antibody Application Details Handling Images back to top
Antigen
Alternative Name Fadd (FADD Antibody Abstract)
Background

FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via the FasL/Fas receptor interaction. The protein contains a C terminal death domain that interacts with the Fas receptor death domain. The N terminus contains a death effectors domain (DED) which recruits caspase to the death inducing signaling complex (DISC) and initiates the apoptotic caspase cascade. Recruitment of Caspase 8 to the Fas receptor results in oligomerization of the Caspase 8 protein, which in turn drives its autoactivation through self-cleavage. Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby commiting the cell to undergo apoptosis. FADD is implicated in non-apoptotic cellular pathways such as the regulation of cell cycle machinery in T lymphocytes. This is connected to the phosphorylation state of FADD and to the FasL/TRAIL induced transcriptional activation of cfos protooncogene. FADD also interacts with the hepatitis C virus core protein in the HEK 293 cell line.


Synonyms: P-Fas-associated protein with death domain, FADD protein, Fas TNFRSF6 associated via death domain, Fas associated via death domain, Fas associating death domain containing protein, Fas associating protein, Fas associating protein with death domain, Fas TNFRSF6 associated via death domain, GIG 3, GIG3, Growth inhibiting gene 3 protein, H sapiens mRNA for mediator of receptor induced toxicity, Mediator of receptor induced toxicity , MGC8528 , MORT 1, MORT1, FADD_HUMAN.
Gene ID 8772
Research Area Cancer, Apoptosis/Necrosis
Pathways Apoptosis, TLR Signaling, Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades

Application Details

Product Details anti-FADD Antibody Target Details FADD Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-FADD Antibody Target Details FADD Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months