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These results suggest that that CXCL14 is a positive allosteric modulator of CXCR4 (show CXCR4 Proteins) via CXCL12 (show CXCL12 Proteins) that enhances the potency of CXCR4 (show CXCR4 Proteins) ligands.
High CXCL14 expression is associated with metastatic progression of Ovarian Cancer.
These results suggest that CXCL14 downregulation by human papillomaviruses plays an important role in suppression of antitumor immune responses.
Platelets are a relevant source of CXCL14. Platelet-derived CXCL14 at the site of vascular lesions might play an important role in vascular repair/regeneration.
Epithelial CXCL14 expression is significantly associated with ERalpha (show ESR1 Proteins) positivity and low proliferation, whereas stromal CXCL14 expression is not linked to any of the established clinicopathological parameters, subtypes of breast cancer or tumour stroma abundance.
Elevated expression of CXCL14 in osteosarcoma tissues correlated with poor prognosis of the osteosarcoma patients.
Data indicate that CXC chemokine (show CXCL12 Proteins) CXCL14, CXC chemokine receptor (show CXCR4 Proteins) CXCR7 (show CXCR7 Proteins) and the ratio between CXC chemokine receptor CXCR4 (show CXCR4 Proteins)-2 and CXCR4 (show CXCR4 Proteins)-1 could predict diseae free survival in Ewing sarcoma patients.
Elevated S100A6 (show S100A6 Proteins) enhances tumorigenesis and suppresses CXCL14-induced apoptosis in clear cell renal cell carcinoma (show MOK Proteins).
three of these five genes (CXCL14, ITGAX (show ITGAX Proteins), and LPCAT2 (show LPCAT2 Proteins)) harbored polymorphisms associated with aggressive disease development in a human GWAS cohort consisting of 1,172 prostate cancer patients.
Prometastatic effects of IRX1 (show IRX3 Proteins) were mediated by upregulation of CXCL14/NF-kappaB (show NFKB1 Proteins) signaling.
CXCL14 Tg mice showed a suppressed rate of carcinogenesis, decreased tumour volume, and reduced pulmonary metastasis, as well as an increased survival rate of mice following tumour cell injection.
CXCL14 does not seem to play a pivotal role during influenza and Escherichia coli infections of the lung.
CXCL14 was able to promote bone metastasis through enhancement of cancer cell tropism to the bone and/or recruitment of bone marrow cells around metastatic cancer cells.
The unique and non-overlapping patterns of CXCL12 (show CXCL12 Proteins) and CXCL14 expression in ocular tissues suggest that these two chemokines may interact and have important functions in cell proliferation, differentiation and migration during eye development.
In conclusion, our results suggested the important function of Cxcl14 in uNK cells and the proper level of Cxcl14 protein were required to recruit NK cells to pregnant uterus.
the transient expression of CXCL14 by Purkinje cells in the developing cerebellum, suggesting that it must be involved in the postnatal maturation of the cerebellum
CXCL14 may play an important role in central nervous system regulation of feeding behavior
Study identifies CXCL14 as a novel marker of tendon connective tissue.
Murine CXCL14 is dispensable for the homeostatic recruitment of antigen-presenting cells toward the periphery and for LC functionality.
This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation.
C-X-C motif chemokine 14
, member a
, small inducible cytokine subfamily b (Cys-X-Cys), member a
, jun-suppressed chemokine
, chemokine (C-X-C motif) ligand 14
, CXC chemokine in breast and kidney
, MIP-2 gamma
, breast and kidney
, chemokine BRAK
, small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK)
, small-inducible cytokine B14
, tumor-suppressing chemokine
, small inducible cytokine B14
, B-cell and monocyte-activating chemokine
, kidney-expressed chemokine CXC
, musculus CXC chemokine MIP-2gamma
, small inducible cytokine subfamily B (Cys-X-Cys), member 14