Browse our PLAT Proteins (PLAT)

Full name:
Plasminogen Activator, Tissue Proteins (PLAT)
On www.antibodies-online.com are 72 Plasminogen Activator, Tissue (PLAT) Proteins from 14 different suppliers available. Additionally we are shipping PLAT Antibodies (324) and PLAT Kits (86) and many more products for this protein. A total of 497 PLAT products are currently listed.
Synonyms:
AU020998, AW212668, D8Ertd2e, PATISS, Plat, T-PA, tPA
list all proteins Gene Name GeneID UniProt
PLAT 5327 P00750
PLAT 18791 P11214
PLAT 25692 P19637

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PLAT Proteins (PLAT) by Origin

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Top referenced PLAT Proteins

  1. Mouse (Murine) PLAT Protein expressed in Insect Cells - ABIN491605 : Lin, Jin, Mars, Reeves, Hu: Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-?B pathways. in The American journal of pathology 2014 (PubMed)
    Show all 9 references for 491605

  2. Human PLAT Protein expressed in CHO - ABIN491596 : Harr, Moore, Chin, Chapman, Ghasabyan, Stringham, Banerjee, Silliman: Viscoelastic hemostatic fibrinogen assays detect fibrinolysis early. in European journal of trauma and emergency surgery : official publication of the European Trauma Society 2015 (PubMed)
    Show all 5 references for 491596

  3. Human PLAT Protein expressed in Human Cells - ABIN2002195 : Boose, Kuismanen, Gerard, Sambrook, Gething: The single-chain form of tissue-type plasminogen activator has catalytic activity: studies with a mutant enzyme that lacks the cleavage site. in Biochemistry 1989 (PubMed)
    Show all 5 references for 2002195

  4. Human PLAT Protein expressed in Insect Cells - ABIN491598 : Mantuano, Lam, Shibayama, Campana, Gonias: The NMDA receptor functions independently and as an LRP1 co-receptor to promote Schwann cell survival and migration. in Journal of cell science 2015 (PubMed)
    Show all 2 references for 491598

  5. Human PLAT Protein expressed in CHO - ABIN491026 : Komissarov, Florova, Idell: Effects of extracellular DNA on plasminogen activation and fibrinolysis. in The Journal of biological chemistry 2011 (PubMed)

More Proteins for PLAT Interaction Partners

Human Plasminogen Activator, Tissue (PLAT) interaction partners

  1. By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.

  2. Data suggest that protein aggregates interact with tissue-type plasminogen activator and plasminogen to efficiently generate plasmin; this aggregate-bound plasmin is shielded from inhibition by alpha-2-antiplasmin and degrades protein aggregates to release smaller, soluble but relatively hydrophobic peptide fragments; these fragments bind to and are cytotoxic to microglia (by not vascular endothelial cells).

  3. Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.

  4. tPA is a ligand of the N-terminal domain of the obligatory GluN1 (show GRIN1 Proteins) subunit of NMDAR (show GRIN1 Proteins) acting as a modulator of their dynamic distribution at the neuronal surface and subsequent signaling.

  5. t-PA binds to Lys91 in the MBP (show MBL2 Proteins) NH2-terminal region and PLGbinds to Lys122 in the MBP (show MBL2 Proteins) COOH-terminal region. This proximity promotes the activation of Pg by t-PA.

  6. local accumulation of cortisol is a causative factor for amnion epithelial apoptosis via activation of tPA/plasmin (show PLG Proteins) system toward the end of gestation. This may contribute to the ROM (show ROM1 Proteins) at both term and preterm birth.

  7. We identified a homozygous null mutation in PLAT that abrogated t-PA level in patient cells. This is the first reported human knockout mutation of PLAT. The apparent association with hydranencephaly, diaphragmatic hernia and postnatal lethality requires further validation.

  8. Tissue plasminogen activator (t-PA) antigen is a marker of cardiovascular risk. Exercise interventions associated with weight loss reduce t-PA antigen. Endurance training per se reduces t-PA antigen in healthy overweight men.

  9. we reviewed current knowledge of mechanisms by which tPA can influence brain function in physiological and pathological conditions--REVIEW}

  10. This study examines the complexes of PAI-1 (show SERPINE1 Proteins) with tissue-type and urokinase-type plasminogen activator (show PLAU Proteins) and vitronectin (show VTN Proteins) revealed by changes in the conformation and dynamics of the reactive center loop.

Mouse (Murine) Plasminogen Activator, Tissue (PLAT) interaction partners

  1. By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity.

  2. Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms.

  3. A model of sustained hyperfibrinolytic state can be obtained in mice by hydrodynamic transfection of a plasmid encoding for tissue-type plasminogen activator (tPA).

  4. While the absence of t-PA confers a more deleterious form of Experimental Autoimmune Encephalomyelitis, neuronal over-expression of t-PA does not overtly protect against this condition with regards to symptom onset or severity of Experimental Autoimmune Encephalomyelitis.

  5. mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA

  6. administration of ADAMTS13 (show ADAMTS13 Proteins) 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA (show RSPH1 Proteins) patency and consequently reduced cerebral infarct sizes

  7. strategies contributing to promote either endogenous production of tPA or its associated EGFR (show EGFR Proteins)-linked signaling pathway may have beneficial effects following brain injuries such as stroke.

  8. Plasminogen (show PLG Proteins) activation contributes to wound repair and suggest that adenosine A2A receptor (show ADORA2A Proteins) activation promotes wound closure by a mechanism that depends on tPA.

  9. Myeloid-derived Tissue-type plasminogen activator (tPA) promotes macrophage migration through a novel signaling cascade involving FAK (show PTK2 Proteins), Rac-1, and NF-kappaB (show NFKB1 Proteins).

  10. the protective effect of neuroserpin (show SERPINI1 Proteins) maybe independent from its canonical interaction with a tissue-type plasminogen activator

Pig (Porcine) Plasminogen Activator, Tissue (PLAT) interaction partners

  1. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. Mild experimental hypothermia markedly reduces ischemia-related coronary tissue plasminogen activator release, which may contribute to the cardioprotective effect of hypothermia.

  3. a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile

  4. ADP acting on the endothelial P2Y(1) M receptor may mediate release of t-PA during ischemia and post-ischemic hyperemia, an effect that may counteract some of the platelet activating effects of ADP

Cow (Bovine) Plasminogen Activator, Tissue (PLAT) interaction partners

  1. The plasminogen/plasminogen (show PLG Proteins) activator/plasmin (show PLG Proteins) system is activated during gamete interaction and regulates the sperm entry into the oocyte.

  2. stage-dependent regulation of granulosa cell PA and SerpinE2 (show SERPINE2 Proteins) production, consistent with a role in extracellular matrix remodeling during follicle growth

  3. These results suggest that Neovastat induces tPA gene transcription through activation of the JNK (show MAPK8 Proteins) and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells.

PLAT Protein Profile

Protein Summary

This gene encodes tissue-type plasminogen activator, a secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding\; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with PLAT

  • plasminogen activator, tissue (PLAT)
  • plasminogen activator, tissue (plat)
  • tissue-type plasminogen activator (tpa)
  • plasminogen activator, tissue (Plat)
  • AU020998 protein
  • AW212668 protein
  • D8Ertd2e protein
  • PATISS protein
  • Plat protein
  • T-PA protein
  • tPA protein

Protein level used designations for PLAT

plasminogen activator, tissue , plasminogen activator, tissue type , tissue-type plasminogen activator , t-PA , t-plasminogen activator , tPA , tissue-type plasminogen activator-like , alteplase , reteplase , tissue plasminogen activator (t-PA) , tissue plasminogen activator , T-plasminogen activator

GENE ID SPECIES
374183 Gallus gallus
472748 Pan troglodytes
594962 Xenopus (Silurana) tropicalis
704475 Macaca mulatta
100049466 Oryzias latipes
100050239 Equus caballus
100173068 Pongo abelii
100391990 Callithrix jacchus
100542402 Meleagris gallopavo
100586515 Nomascus leucogenys
5327 Homo sapiens
18791 Mus musculus
25692 Rattus norvegicus
397121 Sus scrofa
100725281 Cavia porcellus
100009556 Oryctolagus cuniculus
281407 Bos taurus
482840 Canis lupus familiaris
426791 Gallus gallus
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