Browse our anti-SPARC (SPARC) Antibodies

Full name:
anti-Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) Antibodies (SPARC)
On www.antibodies-online.com are 248 Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) Antibodies from 32 different suppliers available. Additionally we are shipping SPARC Kits (60) and SPARC Proteins (42) and many more products for this protein. A total of 359 SPARC products are currently listed.
Synonyms:
AA517111, BM-40, hm:zeh0062, ON, SPARC
list all antibodies Gene Name GeneID UniProt
SPARC 20692 P07214
SPARC 6678 P09486
SPARC 24791 P16975

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Most Popular Reactivities for anti-SPARC (SPARC) Antibodies

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anti-Mouse (Murine) SPARC Antibodies:

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anti-Rat (Rattus) SPARC Antibodies:

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Top referenced anti-SPARC Antibodies

  1. Mouse (Murine) Polyclonal SPARC Primary Antibody for FACS, IHC - ABIN4899335 : Arnold, Rivera, Carbon, Toombs, Chang, Bradshaw, Brekken: Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGF? activation. in PLoS ONE 2012 (PubMed)
    Show all 9 references for 4899335

  2. Human Polyclonal SPARC Primary Antibody for EIA, IHC (fro) - ABIN265179 : Schäkel, Mayer, Federle, Schmitz, Riethmüller, Rieber: A novel dendritic cell population in human blood: one-step immunomagnetic isolation by a specific mAb (M-DC8) and in vitro priming of cytotoxic T lymphocytes. in European journal of immunology 1999 (PubMed)
    Show all 7 references for 265179

  3. Human Polyclonal SPARC Primary Antibody for FACS, IHC - ABIN4899340 : Aguilera, Rivera, Hur, Carbon, Toombs, Goldstein, Dellinger, Castrillon, Brekken: Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma. in Cancer research 2014 (PubMed)
    Show all 7 references for 4899340

  4. Mouse (Murine) Monoclonal SPARC Primary Antibody for FACS, IHC - ABIN4899334 : Weaver, Sage, Yan: Absence of SPARC in lens epithelial cells results in altered adhesion and extracellular matrix production in vitro. in Journal of cellular biochemistry 2006 (PubMed)
    Show all 5 references for 4899334

  5. Human Monoclonal SPARC Primary Antibody for WB - ABIN1882278 : Bradshaw, Graves, Motamed, Sage: SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. in Proceedings of the National Academy of Sciences of the United States of America 2003 (PubMed)
    Show all 3 references for 1882278

  6. Human Polyclonal SPARC Primary Antibody for IF (p), IHC (p) - ABIN738141 : Chen, Wang, Xi, Xue, He, Zhang, Zhao: SPARC is a key regulator of proliferation, apoptosis and invasion in human ovarian cancer. in PLoS ONE 2012 (PubMed)
    Show all 3 references for 738141

  7. Human Polyclonal SPARC Primary Antibody for EIA, WB - ABIN453390 : Said, Frierson, Chernauskas, Conaway, Motamed, Theodorescu: The role of SPARC in the TRAMP model of prostate carcinogenesis and progression. in Oncogene 2009 (PubMed)
    Show all 2 references for 453390

  8. Human Monoclonal SPARC Primary Antibody for FACS, IHC - ABIN4899338 : Moreno, Ball, Andrade, McDermid, Stanimirovic: Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells. in Glia 2006 (PubMed)
    Show all 2 references for 4899338

  9. Human Polyclonal SPARC Primary Antibody for ICC, IF - ABIN4355499 : Kato, Nicholson, Neiman, Rantalainen, Holmes, Barrett, Uhlén, Nilsson, Spector, Schwenk: Variance decomposition of protein profiles from antibody arrays using a longitudinal twin model. in Proteome science 2011 (PubMed)

More Antibodies against SPARC Interaction Partners

Zebrafish Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. these data identify a contributory role for DNA methylation (show HELLS Antibodies) in regulating sparc expression in zebrafish embryogenesis.

  2. Results establish a role for an ECM (show MMRN1 Antibodies) protein (Sparc) as an important regulator of embryonic haematopoiesis during early development in zebrafish.

  3. Data show that Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear in zebrafish.

  4. Sparc is directly required for normal otolith growth

Mouse (Murine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. The results demonstrate for the first time a functional role of the N-propeptide in regulating collagen fiber assembly and cell behavior and suggest that SPARC and the N-propeptide of collagen I have distinct activities in regulating collagen fiber assembly and fibroblast function.

  2. SPARC plays a key role in influencing the spatial organization of the anterior segment, potentially via modulation of collagen properties, while Hevin is not likely to be involved.

  3. An ADAMTS1 (show ADAMTS1 Antibodies) blocking antibody suppressed the SPARC-induced collagen I secretion, indicating that SPARC promoted collagen production directly through ADAMTS1 (show ADAMTS1 Antibodies) interaction. In conclusion, ADAMTS1 (show ADAMTS1 Antibodies) is an important mediator of SPARC-regulated cardiac aging.

  4. SPARC appears to be an important modulator of the actin cytoskeleton, implicating maintenance of muscular function

  5. resistivity measurements were taken on 22 mice, 11 wild-type and 11 sparc-/- (knock out for the protein SPARC: secreted protein acidic and rich in cysteine), bearing mammary carcinomas.

  6. SPARC isoforms, acting on Adipose stromal cells through distinct mechanisms, have an additive effect in inducing ASC (show STS Antibodies) migration.

  7. SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.

  8. SPARC is proposed to act as a critical regulator of transglutaminase activity on collagen I with implications for mechanical strength of tissues.

  9. Tumor-produced SPARC and VCAM1 (show VCAM1 Antibodies) are regulators of cancer extravasation.

  10. The results of this study indicated that the loss of p53 (show TP53 Antibodies) by deletion/mutation in the early stages of glioma formation may cooperate with the induction of SPARC to potentiate cancer cell survival and escape from immune surveillance.

Human Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. SPARC can serve a dual function role as both predictor for prognosis and potentially biomarker for lymph node metastasis in resected pancreatic cancer patients.

  2. SPARC appears to be an important modulator of the actin cytoskeleton, implicating maintenance of muscular function

  3. that SPARC-mediated degradation of the extracellular matrix, and its possible association with MMPs, might contribute to progression of phyllodes tumors

  4. WIN-dependent increase in the level of SPARC plays a critical role in sensitizing osteosarcoma cells to TRAIL action

  5. high SPARC-expression was a significant predictor of poor OS in HPV-negative OPSCC patients using Kaplan-Meier analysis and the log-rank test

  6. We identified five new biomarkers: GDF15 (show GDF15 Antibodies), osteonectin, TRAP5, TWEAK (show TNFSF12 Antibodies), and YKL40 (show CHI3L1 Antibodies) as being promising markers for monitoring bone metastases.

  7. SPARC levels were not associated with efficacy in patients with MPC. This exploratory analysis does not support making treatment decisions regarding nab-paclitaxel plus gemcitabine or gemcitabine alone in MPC based on SPARC expression.

  8. CD90 (show THY1 Antibodies) is upregulated in gastric cancer and inhibits gastric cancer cell apoptosis by modulating the expression level of SPARC protein.

  9. SPARC might be an unfavorable indicator in patients with pancreatic cancer, especially in the stroma.[Review]

  10. tracheal aspirate SPARC levels predicted development of bronchopulmonary dysplasia or death.

Cow (Bovine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. findings indicate that secreted protein acidic cysteine-rich (SPARC) is intricately regulated by pro-angiogenic and other growth factors together with components of the extracellular matrix during the follicle-luteal transition

  2. This study reports the temporal changes in vascular endothelial growth factor A (VEGFA (show VEGFA Antibodies)), fibroblast growth factor 2 (FGF2 (show FGF2 Antibodies)) and osteonectin during the follicular-luteal transition and corpus luteum development in the cow.

Horse (Equine) Secreted Protein, Acidic, Cysteine-Rich (Osteonectin) (SPARC) interaction partners

  1. data suggest that SPARC might modulate angiogenesis during wound healing in the horse, which could protect against the disproportionate fibroplasia commonly afflicting limb wounds and leading to the development of exuberant granulation tissue

SPARC Antigen Profile

Antigen Summary

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion.

Alternative names and synonyms associated with SPARC

  • secreted acidic cysteine rich glycoprotein (sparc) antibody
  • secreted acidic cysteine rich glycoprotein (Sparc) antibody
  • secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) antibody
  • secreted protein, acidic, cysteine-rich (osteonectin) (Sparc) antibody
  • SPARC protein (MGC64258) antibody
  • SPARC-like (LOC100855736) antibody
  • AA517111 antibody
  • BM-40 antibody
  • hm:zeh0062 antibody
  • ON antibody
  • SPARC antibody

Protein level used designations for SPARC

SPARC , osn , osteonectin , ON , basement-membrane protein 40 , secreted protein acidic and rich in cysteine , BM-40 , cysteine-rich protein , Secreted acidic cystein-rich glycoprotein (osteonectin) , secreted acidic cysteine rich glycoprotein

GENE ID SPECIES
321357 Danio rerio
20692 Mus musculus
6678 Homo sapiens
282077 Bos taurus
24791 Rattus norvegicus
595124 Sus scrofa
100009355 Oryctolagus cuniculus
386571 Gallus gallus
100860800 Capra hircus
595143 Canis lupus familiaris
100060119 Equus caballus
100174069 Pongo abelii
379441 Xenopus laevis
100855736 Canis lupus familiaris
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