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Gene deletion studies demonstrated for the first time that lack of NFM (show CEBPB Proteins) leads to changes of D1R (show DRD1 Proteins)-mediated long-term potentiation and D1R (show DRD1 Proteins)-mediated behavior
Data conclude that NF-H (show NEFH Proteins) and NF-M (show CEBPB Proteins) C-terminal domains do not normally regulate NF transport rates as previously proposed, but instead increase the proteolytic resistance of NF, thereby stabilizing the stationary neurofilament cytoskeleton along axons.
Computational modeling predicted that an expanded NF-M C terminus extended farther from the neurofilament core independent of lysine-serine-proline (KSP) phosphorylation.
results obtained in mouse model for leprous neuropathy indicate biochemical alterations in neurofilaments, i.e., hyperphosphorylation of NF-H (show NEFH Proteins) and NF-M (show CEBPB Proteins)
Data show that the tail domain of neurofilament subunit NF-M (show CEBPB Proteins), with seven KSP motifs, is an essential target for the myelination-dependent outside-in signaling cascade that determines axonal caliber and conduction velocity of motor axons.
results demonstrate NF-M (show CEBPB Proteins) tail-mediated interactions of neurofilaments, independent of NF transport rate, are critical determinants of the size and cytoskeletal architecture of axons and are mediated in part by the highly phosphorylated tail domain of NF-M (show CEBPB Proteins)
NF-M regulates the association of NFs with kinesin.
Alpha-internexin (show INA Proteins) coassembles with all 3 neurofilament proteins into a single network of filaments in quadruple-transfected cells. Deleting NF-M (show CEBPB Proteins) alone or together with NF-H (show NEFH Proteins) in mice reduces alpha-internexin (show INA Proteins) transport & content in axons throughout the CNS.
data indicate that a blockade of NMDA receptors during development of cortical neurons increases the phosphorylation state and the solubility of NF-M (show CEBPB Proteins), thereby favoring neurite outgrowth
Phosphorylation of NF-M (show CEBPB Proteins) lysine-serine-proline (KSP) repeats is not an essential component for the acquisition of normal axonal caliber mediated by myelin-dependent outside-in signaling.
NEFM is a negative regulator of aldosterone production and cell proliferation, in part by facilitating D1R (show DRD1 Proteins) internalization from the plasma membrane in Adosterone-producing Adenomas.
direct evidence that NF-M/H are hyperphosphorylated in Alzheimer disease
the importance of alpha-internexin (show INA Proteins) and NF-L (show NEFL Proteins) in regulating the conformations of NF-M and NF-H (show NEFH Proteins)
To study if the increase of levels of neurofilament (NF)-M and NF-L (show NEFL Proteins) in brain of Alzheimer's diseases (AD) is caused by increase of NF-M and NF-L (show NEFL Proteins).
Two polymorphisms of neurofilament M(Ala475Thr and Gly697Arg) occurred at similar frequencies in PD patients and controls. A Pro725Gln substitution and a deletion of valine in position 829 were identified in two PD patients.
O-glycosylation of NF-M is highly dynamic and closely interwoven with phosphorylation cascades and may have a pathophysiological role.
variation in NEF3 influence rate of response to typical antipsychotic medication
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
neurofilament protein M
, neurofilament, medium polypeptide 150kDa
, neurofilament triplet M protein
, CCAAT box/enhancer binding protein beta
, CCAAT/enhancer-binding protein beta
, CCR protein
, c/EBP beta
, transcription factor NF-M
, 160 kDa neurofilament protein
, major neuronal intermediate filament subunit
, neurofilament 3
, neurofilament M subunit
, neurofilament medium polypeptide
, Neurofilament protein, middle polypeptide
, neurofilament 3, medium
, neurofilament-3 (150 kD medium)
, NF-M c-terminus
, NF-M protein
, neurofilament 3 (150kDa medium)
, middle molecular weight neurofilament protein NF-M(1)