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gamma-aminobutyric Acid (GABA) B Receptor, 2 ELISA Kits (GABBR2)
On are 3 gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) ELISA Kits from 1 different suppliers available. Additionally we are shipping GABBR2 Antibodies (198) and GABBR2 Proteins (9) and many more products for this protein. A total of 215 GABBR2 products are currently listed.
GABA(B)R2, GABABR2, Gb2, Gm425, GPR51, GPRC3B, HG20, HRIHFB2099, si:dkey-190l1.2
list all ELISA KIts Gene Name GeneID UniProt
GABBR2 83633 O88871
GABBR2 9568 O75899
GABBR2 242425 Q80T41

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Human gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) interaction partners

  1. a GABBR2 variant, predicted to be disease-causative, was significantly associated with corticospinal excitability at corrected levels. A subsequent uncorrected exploratory analysis revealed associations between GABBR2, GABRA2 (show GABRA2 ELISA Kits) and DRD2 (show DRD2 ELISA Kits) variants with transcranial magnetic stimulation measures of corticospinal excitability and cortical inhibition in Huntington's disease, as well as with age at onset.

  2. The rare variants in GABBR2 were significantly associated with smoking status.

  3. GABBR2 receptors are expressed in aortic smooth muscle cells and regulate the [Ca(2 (show CA2 ELISA Kits)+)]i via a Gi/o-coupled receptor pathway and a phospholipase C (show PLC ELISA Kits) activation pathway.

  4. Putative GABAA (show GABRg1 ELISA Kits) and ASIC1a (show ACCN2 ELISA Kits) channels functionally interact with each other, possibly via an inter-molecular association by forming a novel protein complex.

  5. gamma-aminobutyric acidB receptor proteasomal degradation is mediated by the interaction of the GABAB2 C terminus with the proteasomal ATPase (show DNAH8 ELISA Kits) Rtp6 and regulated by neuronal activity

  6. and GABABR2 proteins are reduced in the prefrontal cortex of aged rats but these reductions are not associated with spatial learning abilities.

  7. The GABBR2 ectodomain adopts a constitutively open conformation, suggesting a structural asymmetry in the active state of GABA(B) receptor that is unique to the GABAergic system.

  8. The results indicate that there may be specific GABA receptor gene expression variation in migraine, particularly involving the GABRA3 (show GABRA3 ELISA Kits) and GABBR2 genes.

  9. The results of this study provided evidence of Gabbr2 Deficit in schizophrenia and mood disorders.

  10. GABA(B) receptor subunit 2 (show CCT2 ELISA Kits) levels are significantly decreased in the cingulate cortex and fusiform gyrus of autism patients compared to controls.

Mouse (Murine) gamma-aminobutyric Acid (GABA) B Receptor, 2 (GABBR2) interaction partners

  1. Immunoblotting and RT-PCR results showed that NIHL increased the expression of PKCgamma (show PRKCG ELISA Kits) but decreased that of GABABR1 (show GABBR1 ELISA Kits) and GABABR2 at both protein and mRNA levels in the CNC

  2. GABABR2 has a role as a regulator of glutamine synthetase (show GLUL ELISA Kits) stability

  3. siRNA knock-down of NgR1 (show NEUROG1 ELISA Kits) resulted in a selective increase of GABAB R1 and GABAB R2 protein and an increase in GIRK1 (show KCNJ3 ELISA Kits).

  4. Cadm1 (show CADM1 ELISA Kits) specifically interacts with Mupp1 (show MPDZ ELISA Kits), and may form a ternary complex with Mupp1 (show MPDZ ELISA Kits)-GABBR2 in the cerebellum.

  5. Gabbr1 (show GABBR1 ELISA Kits) and Gabbr2 transcription levels were altered in cerebral areas related to drug taking only in mice behaviorally classified as "addicted" drinkers

  6. GABA(B)R is predominantly expressed by osteoblasts to negatively regulate osteoblastogenesis through down-regulation of BMP2 (show BMP2 ELISA Kits) expression toward disturbance of osteoclastogenesis after down-regulation of RANKL (show TNFSF11 ELISA Kits) expression in mouse bone.

  7. results suggest that GABA(B)R2 protein levels are closely correlated with the partner subunit GABA(B)R1 (show GABBR1 ELISA Kits) protein levels in mouse brains during postnatal development in vivo

  8. Our data suggest that association of GABAB(2) with GABAB(1 (show GABBR1 ELISA Kits)) is essential for receptor localization in distal processes but not absolutely necessary for signaling. Functional GABAB receptors may exist in neurons that naturally lack GABAB(2) subunits.

  9. Activation of GABA(B) receptor by either GABA or the selective agonist baclofen induces ERK(1 (show MAPK3 ELISA Kits)/2) phosphorylation in cultured cerebellar granule neurons.

  10. GABABR2 are expressed in the cerebellar cortex, supporting previous studies showing that inhibitory neurotransmission is highly patterned in the cerebellar cortex.

GABBR2 Antigen Profile

Antigen Summary

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

Alternative names and synonyms associated with GABBR2

  • gamma-aminobutyric acid (GABA) B receptor, 2 (GABBR2) Elisa Kit
  • gamma-aminobutyric acid (GABA) B receptor, 2 (gabbr2) Elisa Kit
  • gamma-aminobutyric acid (GABA) B receptor 2 (Gabbr2) Elisa Kit
  • gamma-aminobutyric acid (GABA) B receptor, 2 (Gabbr2) Elisa Kit
  • GABA(B)R2 Elisa Kit
  • GABABR2 Elisa Kit
  • Gb2 Elisa Kit
  • Gm425 Elisa Kit
  • GPR51 Elisa Kit
  • GPRC3B Elisa Kit
  • HG20 Elisa Kit
  • HRIHFB2099 Elisa Kit
  • si:dkey-190l1.2 Elisa Kit

Protein level used designations for GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2 , gamma-aminobutyric acid type B receptor subunit 2-like , G protein-coupled receptor 51 , G-protein coupled receptor 51 , GABA-B R2 receptor , GABA-B receptor 2 , GABA-B-R2 , GABA-BR2 , GABABR2 , gamma-aminobutyric acid type B receptor subunit 2 , gb2 , GABA-B receptor, R2 subunit , gamma-aminobutyric acid B receptor 2 , gamma-aminobutyric acid type B receptor, subunit 2 , ortholog of human G protein-coupled receptor 51 GPR51

100063963 Equus caballus
100346845 Oryctolagus cuniculus
100374110 Saccoglossus kowalevskii
100412651 Callithrix jacchus
100448699 Pongo abelii
100476699 Ailuropoda melanoleuca
100561239 Anolis carolinensis
100591607 Nomascus leucogenys
83633 Rattus norvegicus
9568 Homo sapiens
242425 Mus musculus
733216 Xenopus laevis
420979 Gallus gallus
517040 Bos taurus
481627 Canis lupus familiaris
560267 Danio rerio
100511175 Sus scrofa
100170764 Cavia porcellus
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