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Browse our GRM2 Proteins (GRM2)

Full name:
Glutamate Receptor, Metabotropic 2 Proteins (GRM2)
On are 6 Glutamate Receptor, Metabotropic 2 (GRM2) Proteins from 2 different suppliers available. Additionally we are shipping GRM2 Antibodies (100) and GRM2 Kits (11) and many more products for this protein. A total of 122 GRM2 products are currently listed.
4930441L02Rik, GLUR2, Gprc1b, mGlu2, mGluR2, mGluR7
list all proteins Gene Name GeneID UniProt
GRM2 2912 Q14416
GRM2 108068 Q14BI2
Rat GRM2 GRM2 24415 P31421

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GRM2 Proteins (GRM2) by Origin

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Human Glutamate Receptor, Metabotropic 2 (GRM2) interaction partners

  1. The present data demonstrateD that a mechanism of group II mGluR (show GRM8 Proteins)-induced analgesia identified in rodent sensory neurons translates mechanistically to human sensory neurons

  2. this work offers new insights into the functioning of the mGlu2 receptor, which might contribute to the development of new and improved PAMs

  3. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

  4. Study furthers our understanding of positive allosteric modulation of the mGlu2 receptor and can contribute to improved future design of mGlu2 modulators.

  5. Findings suggest that mGluR2/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia

  6. Results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions; antidepressant treatment induces a decrease in 5-HT2AR density

  7. Human anterior cingulate cortex from alcoholic patients shows a significant reduction in mGluR(2) transcripts compared to control subjects

  8. Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A.

  9. the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5 (show GRM5 Proteins), and GRIA3 (show GRIA3 Proteins) genes increased significantly in patients in comparison to healthy controls.

  10. the structural properties for the H8 domain of the mGluR2 receptor; H8 behaves as a sensor of cholesterol concentration.

Mouse (Murine) Glutamate Receptor, Metabotropic 2 (GRM2) interaction partners

  1. These studies provide a foundation for future research seeking to parse out the roles of mGlu2 from mGlu3 (show GRM3 Proteins), paving the way for better understanding of how these receptors regulate activity in the brain.

  2. Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.

  3. provided evidence that JARID1B (show KDM5B Proteins) via modulation of stemness-related signaling is a putative novel therapeutic target for treating malignant NB

  4. Activation of GABA(B) or mGlu2/3 receptors inhibited both evoked presynaptic Ca(2 (show CA2 Proteins)+) transients and striatal field potentials.

  5. In GRM2 knockout mice motor coordination and cognition is unchanged compared to GRM2/3 double knockout mice.

  6. The findings support the possibility that interactions between mGlu2/3 and dopamine may be relevant to the pathophysiology and therapy of schizophrenia and other disorders

  7. mGluR3 (show GRM3 Proteins) knockouts did not differ from controls in reinstatement of drug-seeking behavior, suggesting that mGluR2 receptors are critical in mediating addictive-like behavior.

  8. In the central nervous system, mGluR2 and mGluR4 (show GRM4 Proteins) form a hetero-complex with a distinct pharmacological profile.

  9. The reduction in the expression of mGluR2 and mGluR3 (show GRM3 Proteins) may be involved in the development of benzodiazepine dependence.

  10. 5-HT(2A) receptor-dependent signaling epigenetically affects mGlu2 transcription in mouse frontal cortex.

GRM2 Protein Profile

Protein Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GRM2

  • glutamate receptor, metabotropic 2 (GRM2)
  • glutamate receptor, metabotropic 2 (Grm2)
  • 4930441L02Rik protein
  • GLUR2 protein
  • Gprc1b protein
  • mGlu2 protein
  • mGluR2 protein
  • mGluR7 protein

Protein level used designations for GRM2

glutamate metabotropic receptor 2 , glutamate receptor homolog , metabotropic glutamate receptor 2 , G protein coupled receptor, family C, group 1, member B , G protein-coupled receptor, family C, group 1, member B , mGluR2

2912 Homo sapiens
108068 Mus musculus
24415 Rattus norvegicus
427575 Gallus gallus
519904 Bos taurus
484751 Canis lupus familiaris
101116870 Ovis aries
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