Browse our INPP5K Proteins (INPP5K)

Full name:
Inositol Polyphosphate-5-Phosphatase K Proteins (INPP5K)
On www.antibodies-online.com are 8 Inositol Polyphosphate-5-Phosphatase K (INPP5K) Proteins from 3 different suppliers available. Additionally we are shipping INPP5K Antibodies (25) and many more products for this protein. A total of 39 INPP5K products are currently listed.
Synonyms:
C62, PPS, SKIP
list all proteins Gene Name GeneID UniProt
Rat INPP5K INPP5K 287533  
INPP5K 19062 Q8C5L6
INPP5K 51763 Q9BT40

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INPP5K Proteins (INPP5K) by Origin

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Mouse (Murine) Inositol Polyphosphate-5-Phosphatase K (INPP5K) interaction partners

  1. findings underscore the specific and prominent role of SKIP and GRP78 (show HSPA5 Proteins) in the regulation of insulin (show INS Proteins)-dependent PI 3 (show PI3 Proteins)-kinase signaling in skeletal muscle

  2. prominent role of SKIP in the development of insulin (show INS Proteins) resistance in skeletal muscle

  3. the physiological role of Pak1 (show PAK1 Proteins)-SKIP binding is in the regulation of insulin (show INS Proteins) signaling in skeletal muscle

  4. SKIP controls the IGF-II-PI 3 (show PI3 Proteins)-kinase-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) auto-regulation loop during myogenesis.

  5. Specific suppression of insulin (show INS Proteins) signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1 (show PAK1 Proteins).

  6. Regulation of insulin signaling and glucose transporter 4 (GLUT4) exocytosis by phosphatidylinositol 3,4,5-trisphosphate (PIP3) phosphatase, skeletal muscle, and kidney enriched inositol polyphosphate phosphatase (SKIP).

  7. Results indicate that Inpp5k 5-phosphatase is important for the control of the arginine vasopressin (show AVP Proteins)/aquaporin-2 (show AQP2 Proteins) signalling pathway and water transport in kidney collecting ducts.

  8. Silencer of death domains (SODD (show BAG4 Proteins)) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt (show AKT1 Proteins) signaling to the actin cytoskeleton.

  9. These results imply that SKIP regulates insulin (show INS Proteins) signaling in skeletal muscle.

  10. results suggest that SKIP (skeletal muscle and kidney-enriched inositol phosphatase) plays a negative regulatory role in Akt (show AKT1 Proteins)/ GSK-3beta/GS (glycogen synthase) pathway leading to glycogen (show GYS1 Proteins) synthesis in myocytes

Human Inositol Polyphosphate-5-Phosphatase K (INPP5K) interaction partners

  1. In individuals exhibiting congenital muscular dystrophy, early-onset cataracts, and mild intellectual disability but normal cranial magnetic resonance imaging, we identified bi-allelic mutations in INPP5K, encoding inositol polyphosphate-5-phosphatase K.

  2. Mutations in INPP5K cause a congenital muscular dystrophy syndrome with short stature, cataracts, and intellectual disability.

  3. These findings suggest a model by which GRP78 (show HSPA5 Proteins) regulates intracellular localization of SKIP and how SKIP binds to Pak1 (show PAK1 Proteins) on insulin (show INS Proteins) stimulation.

  4. SKIP controls the IGF-II-PI 3 (show PI3 Proteins)-kinase-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) auto-regulation loop during myogenesis.

  5. Specific suppression of insulin (show INS Proteins) signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1 (show PAK1 Proteins).

  6. The authors report that HBV core protein interacts with a cellular SKIP (skeletal muscle and kidney enriched inositol phosphatase) protein, an endoplasmic reticulum-located phosphoinositide 5-phosphatase (show INPP5B Proteins), both in vivo and in vitro.

INPP5K Protein Profile

Protein Summary

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with INPP5K

  • inositol polyphosphate-5-phosphatase K (Inpp5k)
  • inositol polyphosphate-5-phosphatase K (INPP5K)
  • inositol polyphosphate 5-phosphatase K (Inpp5k)
  • C62 protein
  • PPS protein
  • SKIP protein

Protein level used designations for INPP5K

C62 , inositol polyphosphate 5-phosphatase K , putative phosphoinositide 5-phosphatase type II , putative phosphoinositide 5-phosphatase type II; C62 , skeletal muscle and kidney enriched inositol phosphatase , PI-5-phosphatase related , putative PI-5-phosphatase , skeletal muscle and kidney enriched inositol polyphosphate phosphatase , skeletal muscle and kidney-enriched inositol phosphatase

GENE ID SPECIES
287533 Rattus norvegicus
454410 Pan troglodytes
514123 Bos taurus
19062 Mus musculus
51763 Homo sapiens
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