Browse our SPTAN1 Proteins (SPTAN1)

Full name:
Spectrin alpha Chain, Brain Proteins (SPTAN1)
On are 30 Spectrin alpha Chain, Brain (SPTAN1) Proteins from 4 different suppliers available. Additionally we are shipping SPTAN1 Antibodies (155) and SPTAN1 Kits (23) and many more products for this protein. A total of 213 SPTAN1 products are currently listed.
2610027H02Rik, A2a, EIEE5, im:7157190, IPF, NEAS, SPECA, Spna-2, Spna2, SPTA2, wu:fa20e05, wu:fb33g08, wu:fk32a10, zgc:112229
list all proteins Gene Name GeneID UniProt
SPTAN1 20740  
SPTAN1 6709 Q13813
SPTAN1 64159 P16086

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SPTAN1 Proteins (SPTAN1) by Origin

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More Proteins for SPTAN1 Interaction Partners

Zebrafish Spectrin alpha Chain, Brain (SPTAN1) interaction partners

  1. AlphaII-spectrin in the axonal cytoskeleton is essential for stabilizing nascent sodium-channel clusters and assembling the mature node of Ranvier.

Mouse (Murine) Spectrin alpha Chain, Brain (SPTAN1) interaction partners

  1. Fodrin is a regulatory transporter of gamma-tubulin (show TUBG1 Proteins) to the centrosomes for normal progression of mitosis.

  2. Mena/VASP and alphaII-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy.

  3. Degradation of Spna2 by calpain- and/or caspase is not central to the pathogenesis of 1,2-diacetylbenzene (DAB) axonopathy.

  4. The present study demonstrates the age-dependent intraneuronal presence of an alphaII-spectrin cleavage fragment in mammalian forebrain which is exacerbated in a transgenic model of AD.

  5. alphaII-spectrin deficiency is embryonic lethal, with cardiac, craniofacial and neural tube malformations.

  6. Results of this study provide evidence for a role for spectrin in different steps of megakaryocyte development through its participation in the formation of invaginated membranes and in the maintenance of proplatelet structure.

  7. When cleaved into a 120-kDa product by apoptotic proteases in salivary gland cells in vitro, alpha-fodrin is a successful pathogenic autoantigen for development of autoimmune exocrinopathy in the Sjogren syndrome model.

  8. In heart muscle, alphaII-spectrin is located within the contractile fibres near the Z-disc as well as on the cardiomyocyte plasma membrane.

  9. support a critical role for the alphaII-spectrin-SH3i isoform of spectrin in intracellular targeting of connexin 43 (show GJA1 Proteins) to gap junctions

  10. AlphaII-spectrin-VASP complexes regulate cortical actin cytoskeleton assembly with implications for vascular permeability.

Human Spectrin alpha Chain, Brain (SPTAN1) interaction partners

  1. Alpha-spectrin is critical for recruitment of non-ubiquitinated FANCD2 to sites of damage, which has an important role in the repair response and interstrand cross-link repair.

  2. These results suggest that ubiquitin C-terminal hydrolase and alphaII-spectrin breakdown product 145 kDa may be useful in assessing outcome after pediatric traumatic brain injury.

  3. Variations in both alpha-spectrin (SPTA1) and beta-spectrin ( SPTB ) were found in a neonate with prolonged jaundice in a family where nine individuals had hereditary elliptocytosis.

  4. aggressiveness of MLH1 (show MLH1 Proteins)-positive colorectal cancers might be related to SPTAN1.

  5. hypomyelination of the cerebral white matter was revealed at the age of 1 year, and a de novo heterozygous mutation in the SPTAN1 gene was confirmed

  6. loss of SPTAN1 switches TGF-beta (show TGFB1 Proteins) signaling from tumor suppression to tumor promotion by engaging Notch (show NOTCH1 Proteins) signaling and activating SOX9 (show SOX9 Proteins) in esophageal adenocarcinoma.

  7. organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta (show PKCd Proteins)(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin

  8. In-frame mutations in the C-terminus of SPTAN1 cause a core set of manifestations that include severe intellectual disability, generalized epilepsy, and pontocerebellar atrophy.

  9. Analysis of alphaII-spectrin breakdown products in cerebrospinal fluid predicts mortality and injury severity in adults following traumatic brain injury.

  10. findings suggest that pathological aggregation of alpha/beta spectrin heterodimers and abnormal axon initial segment(AIS (show AR Proteins)) integrity resulting from SPTAN1 mutations were involved in pathogenesis of infantile epilepsy

SPTAN1 Protein Profile

Protein Summary

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with SPTAN1

  • spectrin, alpha, non-erythrocytic 1 (SPTAN1)
  • spectrin alpha 2 (spna2)
  • Spectrin alpha chain, brain (spta2)
  • spectrin alpha, non-erythrocytic 1 (Sptan1)
  • spectrin, alpha, non-erythrocytic 1 (Sptan1)
  • spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) (SPTAN1)
  • 2610027H02Rik protein
  • A2a protein
  • EIEE5 protein
  • im:7157190 protein
  • IPF protein
  • NEAS protein
  • SPECA protein
  • Spna-2 protein
  • Spna2 protein
  • SPTA2 protein
  • wu:fa20e05 protein
  • wu:fb33g08 protein
  • wu:fk32a10 protein
  • zgc:112229 protein

Protein level used designations for SPTAN1

alpha-fodrin , spectrin alpha chain, brain , spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) , cardiomyocyte alpha-spectrin , sequence with a GC signal , alpha2 spectrin , Spectrin alpha chain, brain , alpha-II spectrin , alpha-spectrin 2, brain , fodrin alpha chain , spectrin alpha 2 , spectrin alpha chain, non-erythrocytic 1 , spectrin, non-erythroid alpha chain , spectrin, non-erythroid alpha subunit , a--fodrin , alpha II spectrin , alpha-spectrin 2 , brain alpha-spectrin , inhibitory protein factor , noerythroid alpha-spectrin 2 , nonerythroid alpha-spectrin 2 , alpha-spectrin , nonerythroid alpha-spectrin

540108 Bos taurus
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553383 Danio rerio
100380773 Salmo salar
20740 Mus musculus
6709 Homo sapiens
64159 Rattus norvegicus
374234 Gallus gallus
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