Browse our Claudin 18 Proteins (CLDN18)

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Claudin 18 Proteins (CLDN18)
On www.antibodies-online.com are 4 Claudin 18 (CLDN18) Proteins from 2 different suppliers available. Additionally we are shipping Claudin 18 Antibodies (60) and Claudin 18 Kits (25) and many more products for this protein. A total of 94 Claudin 18 products are currently listed.
Synonyms:
claudin-18, CLDN18, SFTA5, SFTPJ
list all proteins Gene Name GeneID UniProt
CLDN18 51208 P56856
CLDN18 56492 P56857
Rat CLDN18 CLDN18 315953  

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Claudin 18 Proteins (CLDN18) by Origin

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Human Claudin 18 (CLDN18) interaction partners

  1. The presented data substantiate the hypothesis that claudin-18 is a central barrier-forming component of tight junctions and show that IL-13 (show IL13 Proteins) downregulates claudin-18. These data also suggest that the loss of claudin-18 is associated with increased sensitization to aeroantigens and airway responsiveness

  2. suggest that the reduction of CLDN5 (show CLDN5 Proteins), 7, and 18 expression loses the suppressive ability of interaction between PDK1 (show PDK1 Proteins) and Akt (show AKT1 Proteins) and causes sustained phosphorylation of Akt (show AKT1 Proteins), resulting in the disordered proliferation in lung squamous carcinoma cells

  3. Data suggest that claudin-18 suppresses the abnormal proliferation and motility of lung epithelial cells mediated by inhibition of phosphorylation of pyruvate dehydrogenase kinase isoform 1 (PDK1 (show PDK1 Proteins)) and proto-oncogene (show RAB1A Proteins) protein c-akt (Akt (show AKT1 Proteins)).

  4. Human fetal lungs at 23-24 weeks gestational age, the highest-risk period for developing bronchopulmonary dysplasia, a disease of impaired alveolarization, had significantly lower CLDN18 expression relative to postnatal lungs.

  5. Evaluated expression of claudins in gastric cancer and determined their significance for patient outcome. Claudin-3 (show CLDN3 Proteins) and claudin-7 (show CLDN7 Proteins) were expressed in 25.4% and 29.9% of gastric cancer tissues; 51.5% of gastric cancer tissues had reduced claudin-18.

  6. High levels of CLDN18 are associated with non-small-cell lung cancer.

  7. Downregulation of miR (show MLXIP Proteins)-1303 can inhibit proliferation, migration and invasion of gastric cancer cells by targeting CLDN18.

  8. Claudin-18 positivity is a specific phenotype that is characteristic of intestinal-type Mucinous borderline tumours of the ovary

  9. Down-regulation of claudin-18 is associated with the proliferative and invasive potential of gastric cancer.

  10. Reduced expression of olfactomedin 4 (show OLFM4 Proteins) and ectopic expression of claudin-18 might be useful markers in the differential diagnosis of serrated polyps.

Mouse (Murine) Claudin 18 (CLDN18) interaction partners

  1. The presented data substantiate the hypothesis that claudin-18 is a central barrier-forming component of tight junctions and show that IL-13 (show IL13 Proteins) downregulates claudin-18. These data also suggest that the loss of claudin-18 is associated with increased sensitization to aeroantigens and airway responsiveness

  2. The claudin-18 knockout mice exhibited decreased P2X7 (show P2RX7 Proteins) mRNA transcript abundance as measured by mRNA expression microarray

  3. CLDN18 deficiency results in epithelial barrier dysfunction, injury, and impaired alveolarization in mice.

  4. Identify a role for claudin 18 in alveolar fluid homeostasis beyond its direct contributions to barrier properties.

  5. we conclude that the estrogen effects on osteoclasts may in part be mediated via regulation of Cldn-18 signaling

  6. Claudin-18 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area.

  7. Cldn-18 is a novel negative regulator of bone resorption and osteoclast differentiation

  8. Claudin-18 forms a paracellular barrier against H(+) in the stomach. Deficiency causes paracellular H(+) leak, up-regulation of proinflammatory cytokines, recruitment of neutrophils, and atrophic gastritis.

  9. Increased expression of claudin-18 is associated with ulcerative colitis.

Claudin 18 (CLDN18) Protein Profile

Protein Summary

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with Claudin 18 (CLDN18)

  • claudin 18 (cldn18)
  • claudin 18 (CLDN18)
  • claudin 18 (LOC100349260)
  • claudin 18 (Cldn18)
  • claudin-18 protein
  • CLDN18 protein
  • SFTA5 protein
  • SFTPJ protein

Protein level used designations for Claudin 18 Proteins (CLDN18)

claudin 18 , claudin-18 , surfactant associated 5 , surfactant associated protein J , surfactant, pulmonary associated protein J , claudin 18-like

GENE ID SPECIES
398928 Xenopus laevis
429135 Gallus gallus
470935 Pan troglodytes
716628 Macaca mulatta
100349260 Oryctolagus cuniculus
51208 Homo sapiens
477079 Canis lupus familiaris
100294676 Sus scrofa
511460 Bos taurus
56492 Mus musculus
315953 Rattus norvegicus
101112106 Ovis aries
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