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altered profile of the bone matrix components in Cx37-deficient mice acts in favor of higher resistance to fracture in long bones.
NO controls the calcium signal propagation through Cx37-containing gap junctions. The tyrosine phosphatase SHP-2 is the essential mediator and NO target.
Cx37 deletion increased the size of atherosclerotic lesions in oscillatory shear stress regions and abrogated the development of a stable plaque phenotype under OSS in ApoE (show APOE Proteins)(-/-) mice
Data show that segregation of Foxc2 (show FOXC2 Proteins) and NFATc1 (show NFATC1 Proteins) transcription factor is closely associated with the highly polarized expression of connexins Cx37, Cx43 (show GJA1 Proteins), and Cx47 (show GJC2 Proteins).
administration of 0.3 IU/mL FSH (show BRD2 Proteins) during ovarian cryopreservation by vitrification can maintain ovarian survival during ovarian vitrification and increases the blood supply with avascular transplantation via upregulation of Cx43 (show GJA1 Proteins), Cx37, and VEGF (show VEGFA Proteins)/VEGFR2 (show KDR Proteins)
Cx37 is more markedly involved in basal NO release, release of cyclooxygenase products and the regulation of the sensitivity for Acetylcholine as compared to Cx40 (show GJA5 Proteins).
Foxc2 (show FOXC2 Proteins) and Cx37 are elements in a common molecular pathway directing lymphangiogenesis.
The data suggest that the P2Y2 (show P2RY2 Proteins)/4 receptor activation elicits blood pressure responses via distinct mechanisms involving KCa3.1 (show KCNN4 Proteins) and Cx37.
Both connexin isoforms are required for meiotic arrest and with the reported localization of connexin-43 (show GJA1 Proteins) throughout the cumulus cells and connexin-37 at the oocyte surface.
Endothelial connexin 40 (show GJA5 Proteins), but not connexin 37, is implicated in resistance of the heart to ischaemia/reperfusion injury by activation of the CD73 pathway
The CX37 rs1764390 G allele is associated with increased susceptibility to sepsis, which may be involved in the process of sepsis via mediating the plasma levels of NO, IL-6 (show IL6 Proteins) and CRP (show CRP Proteins).
Results suggest polymorphisms of Cx37 rs1630310 and Cx43 (show GJA1 Proteins) rs1925223 genes may be associated with the pathogenesis of essential hypertension.
The C allele in the CX37 gene might be associated with susceptibility to dilated cardiomyopathy (DCM) in Chinese Han; female carriers of the C allele had higher DCM risk compared with TT homozygotes than males
The protective effect of the T allele of the Cx37 gene might be strongly modified by smoking; in women, this effect could be mediated through stem cells.
Our findings suggest that the Cx37 C1019T variation may contribute to the risk of PCOS in the South Indian women.
Review/Meta-analysis: Cx37 C1019T was a risk factor for myocardial infarction and a protective factor for coronary artery disease.
The C allele in the CX37 gene might be associated with the susceptibility to EH in population of Wuxi, China.
three variants in PNPLA3 (show PNPLA3 Proteins) gene may be a genetic risk factor for NASH (show SAMSN1 Proteins)
Determination of Cx37 C1019T and eNOS (show NOS3 Proteins) G894T polymorphisms may be used to detect a genetic predisposition to the development of myocardial infarction in patients with hemodynamically insignificant atherosclerosis and in apparently healthy individuals.
1019C/T polymorphism in the CX37 gene is associated with susceptibility to coronary artery disease as well as restenosis after coronary stenting in male patients.
This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction.
, gap junction alpha-4 protein
, gap junction membrane channel protein alpha 4
, Gap junction membrane channel, protein alpha 4 (connexin 37)
, connexin 37
, connexin 39
, gap junction protein, alpha 4, 37kDa
, gap junctional connexin alpha4