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Human Polyclonal PARD6B Primary Antibody for ELISA, WB - ABIN1535144
Gao, Macara, Joberty: Multiple splice variants of Par3 and of a novel related gene, Par3L, produce proteins with different binding properties. in Gene 2002
Show all 2 references for 1535144
Human Polyclonal PARD6B Primary Antibody for ELISA, WB - ABIN347091
Vinot, Le, Maro, Louvet-Vallée: Two PAR6 proteins become asymmetrically localized during establishment of polarity in mouse oocytes. in Current biology : CB 2004
Show all 2 references for 347091
Cow (Bovine) Polyclonal PARD6B Primary Antibody for WB - ABIN2775631
Labhart, Karmakar, Salicru, Egan, Alexiadis, OMalley, Smith: Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator. in Proceedings of the National Academy of Sciences of the United States of America 2005
PAK4 (show PAK4 Antibodies) phosphorylates Par6B at Ser143 blocking its interaction with Cdc42 (show CDC42 Antibodies).
Pard6b is necessary for blastocyst morphogenesis
found that the polarity determinants Cdc42 (show CDC42 Antibodies), Par6B, PKCzeta (show PRKCZ Antibodies)/iota and the structural proteins ezrin (show EZR Antibodies) and phospho-ezrin (show EZR Antibodies) were lost from the apical membrane and accumulated either in the cytoplasm or on the basal side of enterocytes in patients
Data conclude that Par6B and aPKC control mitotic spindle orientation in polarized epithelia and, furthermore, that aPKC coordinately regulates multiple processes to promote morphogenesis.
This study demonstrates that controlled regulation of PAK4 (show PAK4 Antibodies) is required for apical junction formation in lung epithelial cells and highlights potential cross-talk between two Cdc42 (show CDC42 Antibodies) targets, PAK4 (show PAK4 Antibodies) and Par6B.
The ability of SRC (show SRC Antibodies) family coactivators to regulate the expression of one of these genes, PARD6B/Par6, was confirmed by using cells individually depleted of SRC-1 (show SRC Antibodies).
Interaction between PAR-3 (show F2RL2 Antibodies) and the aPKC-PAR-6 (show PARD6A Antibodies) complex is indispensable for apical domain development of epithelial cells.
Data indicate that the polarity protein Partitioning defective-6 homolog beta (Par6b) regulates not only the dynamics of apicobasal polarity but also integrity of the developing stratified epidermis.
ephrinB1 (show EFNB1 Antibodies) associates with the Par (show AFG3L2 Antibodies) polarity complex protein Par-6 (show PARD6A Antibodies) and can compete with the small GTPase (show RACGAP1 Antibodies) Cdc42 (show CDC42 Antibodies) for association with Par-6.
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex.
par-6 partitioning defective 6 homolog beta (C. elegans)
, PAR-6 beta
, partitioning defective 6 homolog beta
, partitioning-defective protein 6, beta
, par-6 partitioning defective 6 homolog beta
, partitioning defective 6 beta