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In contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival.
Perp might play important roles in the formation and integration of stellate reticulum, dental lamina structure and enamel formation
an important role for Perp in normal mammary tissue function and in mammary cancer suppression
Data show that PERP is necessary for the integrity of the ameloblast-SI interface and that a lack of Perp causes downregulation of genes that are required for proper enamel formation.
Studies suggest that Perp-deficiency promotes cancer by enhancing cell surv (show CDH1 Proteins)ival, desmosome loss, and inflammatio (show CYP11A1 Proteins)n, and they highlight a fundamental role for Perp and desmosomes in tumor suppression.
In contrast to p53 shRNAs, PUMA shRNAs were unable to cooperate with oncogenic ras in transformation
Perp is a key effector in the p63 (show CKAP4 Proteins) developmental program.
Perp is required for efficient skin carcinogenesis and suggest a role for intact cell-cell adhesion in supporting tumor development in these settings.
Perp is requered throughout adult life for proper epithelial homeostasis and function.
PERP, a p53 (show TP53 Proteins) proapoptotic target, mediates apoptotic cell death in renal ischemia.
pemphigus vulgaris (show DSG3 Proteins) autoantibodies disrupt Perp expression at the membrane and trigger its internalization along with DSG3 (show DSG3 Proteins) into the endosomal pathway, where it is ultimately targeted to the lysosome for degradation
Downregulation of desmosomal formation transcripts including PERP may contribute to the aggressive phenotype seen in sparsely granulated GH pituitary tumors and their behavior in response to surgery and medical therapy.
Expression of p63 (show RPE65 Proteins)-tGFP induces apoptosis with marked increase in PERP expression and associated p53 (show TP53 Proteins) accumulation. Lack of p63 (show RPE65 Proteins) contributes to reduced PERP levels and impaired p53 (show TP53 Proteins)-mediated apoptosis in UM.
Salmonella Typhimurium type III secreted effector SipC significantly contributes to PERP redistribution to the apical membrane surface.
The authors identified the tetraspanning membrane protein, p53 (show TP53 Proteins) effector related to PMP-22 (show PMP22 Proteins) (PERP), as a Salmonella typhimurium SipA binding partner.
Decreased PERP expression on peripheral blood mononuclear cells from patient with rheumatoid arthritis negatively correlates with disease activity.
Perp expression is reduced in human breast cancer cell lines
PERP expression stabilizes active p53 (show TP53 Proteins) via modulation of p53 (show TP53 Proteins)-MDM2 (show MDM2 Proteins) interaction in uveal melanoma cells.
Data suggest a temporal sequence whereby PERP loss occurs before E-cadherin (show CDH1 Proteins) loss in the progression of human SCC (show CYP11A1 Proteins).
findings underline the apoptotic pathway mediated by PERP as a critical mechanism employed by uveal melanoma tumours to modulate susceptibility to apoptosis
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway (By similarity).
PERP, TP53 apoptosis effector
, TP53 apoptosis effector
, p53 apoptosis effector related to PMP-22
, p53 apoptosis effector related to pmp-22
, keratinocyte-associated protein 1
, p53 apoptosis effector related to Pmp22
, p53 apoptosis-associated target
, keratinocytes associated protein 1
, p53 apoptosis effector related to PMP22
, p53-induced protein PIGPC1
, transmembrane protein THW