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In vitro function assays demonstrated that SPRY4 (show SPRY4 Proteins)-IT1 (show HAUS3 Proteins) cause promotion of cell viability in ESCC cells. Authors further verified that SPRY4 (show SPRY4 Proteins)-IT1 (show HAUS3 Proteins) could also activate the expression of ZNF703 in ESCC cells, which might contribute to the role of SPRY4 (show SPRY4 Proteins)-IT1 (show HAUS3 Proteins) in ESCC cells.
Results show that ZNF703 overexpression is associated with adverse prognosis in head and neck squamous cell carcinomas, which might be a novel biomarker for this type of neoplasm.
ZNF703 was a target of SPRY4 (show SPRY4 Proteins)-IT1 (show HAUS3 Proteins).
Results show that ZNF703 expression is upregulated in colorectal cancer tissues (CRC (show CALR Proteins)) and is significantly correlated with tumor size, pathological grading, and serosal and lymph node metastasis suggesting that it may act as an oncogene (show RAB1A Proteins) in CRC (show CALR Proteins).
The results showed that ZNF703 acts as a gastric cancer oncogene (show RAB1A Proteins)
High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer.
Data indicate that ZNF703 overexpression in MCF-7 breast cancer cells activated the Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling pathway, downregulated ERalpha (show ESR1 Proteins), and reduced the antitumor effect of tamoxifen.
The conserved domains are essential for proper subcellular localization and transcriptional repression of the NLZ1/ZNF703 protein.
ZNF703 expression results in the activation of stem cell-related gene expression leading to an increase in cancer stem cells.
These data strongly point to ZNF703 as a novel oncogene (show RAB1A Proteins) in Luminal B breast cancer.
Zeppo1 is a key regulator of breast cancer progression
Nlz1 is required for cilia formation in zebrafish embryogenesis.
nlz1 is expressed in the presumptive hindbrain and midbrain/hindbrain boundary. nlz2 (show ZNF503 Proteins) is uniquely expressed more anteriorly, in the presumptive midbrain and diencephalon.
Nlz1/Znf703 acts as a repressor of transcription
identify misregulation of pax2 (show PAX2 Proteins) in the developing eye of morphant fish, suggesting that Nlz1 and Nlz2 (show ZNF503 Proteins) act upstream of the Pax2 (show PAX2 Proteins) pathway in directing proper closure of the optic fissure
Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development.
zinc finger elbow-related proline domain protein 1
, ES neuronal differentiation 2
, nocA related zinc finger 1
, nocA-like zinc finger protein 1
, nocA-related zinc finger protein 1