Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
Strong ERK (show MAPK1 ELISA Kits) activation can target Cdc25A (show CDC25A ELISA Kits) for degradation in a manner similar to, but independent of, Chk1 (show CHEK1 ELISA Kits) for cell cycle arrest.
beta-TRCP depletion in HepG2 hepatocellular carcinoma cells resulted in increased Lipin1 protein abundance.
It demonstrates that degradation of Lipin-1 (show LPIN1 ELISA Kits) is regulated by BTRC in the cytoplasm and on membranes
we identified two independent SNPs (i.e., WNT2B (show WNT2B ELISA Kits) rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 x 10(-5)) and 0.61 (0.46-0.80, 3.12x10(-4)), respectively.
It has been proposed that CENP-W (show CENPW ELISA Kits) may function as a booster of beta-TrCP1 nuclear import to increase the oncogenicity of beta-TrCP1.
oncogenic effect of miR (show MLXIP ELISA Kits)-182 and its reversal by beta-TrCP2 were confirmed in vivo This study suggests that beta-TrCP and miR (show MLXIP ELISA Kits)-182 may be possible biomarkers and targets for early detection and treatment of pancreatic cancer
Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H (show CREB3L3 ELISA Kits).
Phosphorylated VEGFR-2 (show KDR ELISA Kits) was reduced by hyperglycemia while total VEGFR-2 (show KDR ELISA Kits) was almost unaltered. However, VEGFR-2 (show KDR ELISA Kits) was reduced when directly exposed to reactive oxygen species, with resultant co-location of beta-TrCP and VEGFR-2 (show KDR ELISA Kits).
Low GAS7C increases cancer cell motility by promoting N-WASP/FAK (show PTK2 ELISA Kits)/F-actin cytoskeleton dynamics. It also enhances beta-catenin (show CTNNB1 ELISA Kits) stability via hnRNP U (show HNRNPU ELISA Kits)/beta-TrCP complex formation.
EBV-miR (show MLXIP ELISA Kits)-BART10-3p facilitated epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC.
beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth
beta-TrCP regulates the transition from mitosis to meiosis in male germ cells by targeting DMRT1 (show DMRT1 ELISA Kits) for degradation.
Data indicate a critical physiological function of beta-TRCP in regulating hepatic lipid metabolic homeostasis in part through modulating Lipin1 (show LPIN1 ELISA Kits) stability.
betaTrCP levels are correlated with imiquimod-induced skin lesion.
Erbin (show ERBB2IP ELISA Kits) as a novel substrate of SAG (show RNF7 ELISA Kits)-betaTrCP E3 ligase.
these results clearly suggest that both beta-TrCP- and Hrd1 (show SYVN1 ELISA Kits)-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 ELISA Kits) to maintain cellular homeostasis.
beta-TrCP may be an essential player in UVB induced responses in skin
Glycogen synthase kinase 3 (show GSK3a ELISA Kits) phosphorylates a group of Ser (show SIGLEC1 ELISA Kits) residues in the Neh6 domain of mouse Nrf2 (show NFE2L2 ELISA Kits) that overlap with an SCF (show KITLG ELISA Kits)/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1 (show KEAP1 ELISA Kits)-independent manner.
LPS (show TLR4 ELISA Kits) appears to destabilize the LPCAT1 (show LPCAT1 ELISA Kits) protein by GSK-3beta (show GSK3b ELISA Kits)-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination.
the two beta-TrCP paralogs have a nonredundant role in spermatogenesis
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.
beta-transducin repeat containing
, beta-transducin repeat containing protein
, F-box/WD repeat-containing protein 1A
, f-box/WD repeat-containing protein 1A-like
, F-box and WD repeats protein beta-TrCP
, F-box and WD-repeat protein 1B
, epididymis tissue protein Li 2a
, pIkappaBalpha-E3 receptor subunit
, beta-transducin repeat-containing protein
, SCF b-TRCP
, beta-TrCP protein E3RS-IkappaB
, pIkappaB-E3 receptor subunit
, ubiquitin ligase FWD1