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Strong ERK (show MAPK1 ELISA Kits) activation can target Cdc25A (show CDC25A ELISA Kits) for degradation in a manner similar to, but independent of, Chk1 (show CHEK1 ELISA Kits) for cell cycle arrest.
It demonstrates that degradation of Lipin-1 (show LPIN1 ELISA Kits) is regulated by BTRC in the cytoplasm and on membranes
we identified two independent SNPs (i.e., WNT2B (show WNT2B ELISA Kits) rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 x 10(-5)) and 0.61 (0.46-0.80, 3.12x10(-4)), respectively.
It has been proposed that CENP-W (show CENPW ELISA Kits) may function as a booster of beta-TrCP1 nuclear import to increase the oncogenicity of beta-TrCP1.
oncogenic effect of miR (show MLXIP ELISA Kits)-182 and its reversal by beta-TrCP2 were confirmed in vivo This study suggests that beta-TrCP and miR (show MLXIP ELISA Kits)-182 may be possible biomarkers and targets for early detection and treatment of pancreatic cancer
Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H (show CREB3L3 ELISA Kits).
Phosphorylated VEGFR-2 (show KDR ELISA Kits) was reduced by hyperglycemia while total VEGFR-2 (show KDR ELISA Kits) was almost unaltered. However, VEGFR-2 (show KDR ELISA Kits) was reduced when directly exposed to reactive oxygen species, with resultant co-location of beta-TrCP and VEGFR-2 (show KDR ELISA Kits).
Low GAS7C increases cancer cell motility by promoting N-WASP (show WASL ELISA Kits)/FAK (show PTK2 ELISA Kits)/F-actin cytoskeleton dynamics. It also enhances beta-catenin (show CTNNB1 ELISA Kits) stability via hnRNP U (show HNRNPU ELISA Kits)/beta-TrCP complex formation.
EBV-miR (show MLXIP ELISA Kits)-BART10-3p facilitated epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC.
beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth
This study showed SCF (show KITLG ELISA Kits)(beta-TRCP) earmarks Set8 (show SETD8 ELISA Kits) for ubiquitination and degradation in a casein kinase I (show CSNK1D ELISA Kits)-dependent manner, which is activated by DNA-damaging agents.
betaTrCP levels are correlated with imiquimod-induced skin lesion.
Erbin (show ERBB2IP ELISA Kits) as a novel substrate of SAG (show RNF7 ELISA Kits)-betaTrCP E3 ligase.
these results clearly suggest that both beta-TrCP- and Hrd1 (show SYVN1 ELISA Kits)-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 ELISA Kits) to maintain cellular homeostasis.
beta-TrCP may be an essential player in UVB induced responses in skin
Glycogen synthase kinase 3 (show GSK3a ELISA Kits) phosphorylates a group of Ser (show SIGLEC1 ELISA Kits) residues in the Neh6 domain of mouse Nrf2 (show NFE2L2 ELISA Kits) that overlap with an SCF (show KITLG ELISA Kits)/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1 (show KEAP1 ELISA Kits)-independent manner.
LPS (show TLR4 ELISA Kits) appears to destabilize the LPCAT1 (show LPCAT1 ELISA Kits) protein by GSK-3beta (show GSK3b ELISA Kits)-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination.
the two beta-TrCP paralogs have a nonredundant role in spermatogenesis
anti-inflammatory effects of H(2)O(2) may result from its ability to decrease ubiquitination as well as subsequent degradation of I kappaB alpha through inhibiting the association between I kappaB alpha and SCF (show KITLG ELISA Kits)(beta-TrCP)
BMP-2 (show BMP2 ELISA Kits) modulates beta-catenin (show CTNNB1 ELISA Kits) signaling through stimulation of Lrp5 (show LRP5 ELISA Kits) expression and inhibition of beta-TrCP expression in osteoblasts
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.
beta-transducin repeat containing
, beta-transducin repeat containing protein
, F-box/WD repeat-containing protein 1A
, f-box/WD repeat-containing protein 1A-like
, F-box and WD repeats protein beta-TrCP
, F-box and WD-repeat protein 1B
, epididymis tissue protein Li 2a
, pIkappaBalpha-E3 receptor subunit
, beta-transducin repeat-containing protein
, SCF b-TRCP
, beta-TrCP protein E3RS-IkappaB
, pIkappaB-E3 receptor subunit
, ubiquitin ligase FWD1