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Browse our anti-CDK5 (CDK5) Antibodies

Full name:
anti-Cyclin-Dependent Kinase 5 Antibodies (CDK5)
On www.antibodies-online.com are 236 Cyclin-Dependent Kinase 5 (CDK5) Antibodies from 26 different suppliers available. Additionally we are shipping CDK5 Kits (46) and CDK5 Proteins (17) and many more products for this protein. A total of 312 CDK5 products are currently listed.
Synonyms:
AW048668, cdk5, CG8203, Crk6, DmCdk5, Dmel\\CG8203, PSSALRE, zgc:101604

Most Popular Reactivities for anti-CDK5 (CDK5) Antibodies

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anti-Human CDK5 Antibodies:

anti-Mouse (Murine) CDK5 Antibodies:

anti-Rat (Rattus) CDK5 Antibodies:

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Top referenced anti-CDK5 Antibodies

  1. Human Monoclonal CDK5 Primary Antibody for IHC (fro), WB - ABIN782438 : Nguyen, Bibb: Cdk5 and the mystery of synaptic vesicle endocytosis. in The Journal of cell biology 2003 (PubMed)
    Show all 4 references for ABIN782438

  2. Human Monoclonal CDK5 Primary Antibody for IF, IP - ABIN115138 : Matsushime, Roussel, Ashmun, Sherr: Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. in Cell 1991 (PubMed)
    Show all 4 references for ABIN115138

  3. Human Monoclonal CDK5 Primary Antibody for WB - ABIN1945087 : Meyerson, Enders, Wu, Su, Gorka, Nelson, Harlow, Tsai: A family of human cdc2-related protein kinases. in The EMBO journal 1992 (PubMed)
    Show all 2 references for ABIN1945087

  4. Human Monoclonal CDK5 Primary Antibody for ICC, FACS - ABIN969041 : Zhang, Herrup: Cdk5 and the non-catalytic arrest of the neuronal cell cycle. in Cell cycle (Georgetown, Tex.) 2008 (PubMed)
    Show all 2 references for ABIN969041

  5. Human Polyclonal CDK5 Primary Antibody for IF (p), IHC (p) - ABIN670101 : Yin, Qi, Ren, Wang, Jiang, Feng, Cui: Roscovitine treatment caused impairment of fertilizing ability in mice. in Toxicology letters 2015 (PubMed)
    Show all 2 references for ABIN670101

  6. Human Monoclonal CDK5 Primary Antibody for WB - ABIN1944859 : Li, Liu, Zhang, Ye, Qiao, Ling, Wu, Zhang, Yu: Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling. in Molecular biology reports 2010 (PubMed)
    Show all 2 references for ABIN1944859

  7. Chicken Polyclonal CDK5 Primary Antibody for WB - ABIN2780625 : Otyepka, Bártová, Kríz, Koca: Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics. in The Journal of biological chemistry 2006 (PubMed)

  8. Chicken Polyclonal CDK5 Primary Antibody for WB - ABIN2792160 : Liu, Tian, Gearing, Hunter, Ye, Mao: Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Antibodies against CDK5 Interaction Partners

Human Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. the activated CDK5 kinase is involved in the EZH2 (show EZH2 Antibodies) phosphorylation that is required for FBW7 (show FBXW7 Antibodies)-mediated degradation.

  2. we supposed that EphA4 (show EPHA4 Antibodies) interacted with CDK5 and promoted its expression which in turn enhanced p-AKT (show AKT1 Antibodies) expression and promoted cell adhesion-mediated drug resistance in multiple myeloma.

  3. the minor allele of CDK5R1 (show CDK5R1 Antibodies) 3'-UTR (show UTS2R Antibodies) rs735555 polymorphism was associated with increased risk for NS-ID. In conclusion, our data suggest that mutations and polymorphisms in CDK5 and CDK5R1 (show CDK5R1 Antibodies) genes may contribute to the onset of the NS-ID phenotype

  4. CDK5 was dynamically modified with O-GlcNAc (show OGT Antibodies) in response to neuronal activity and that glycosylation represses CDK5-dependent apoptosis by impairing its association with p53 (show TP53 Antibodies) pathway.

  5. CDK5 may play a vital role in the development of cervical cancer, which may be a marker for the diagnosis, therapy and prognosis of cervical cancer.

  6. the results suggest that CK1delta activity can be modulated by the interplay between CK1delta and CDK2 (show CDK2 Antibodies)/E or CDK5/p35 (show ANXA1 Antibodies).

  7. Cdk5-mediated phosphorylation of CHIP negatively regulates its neuroprotective function, thereby contributing to neuronal cell death progression following neurotoxic stimuli.

  8. High cyclin-dependent kinase 5 expression is associated with non-small cell lung cancer and small cell lung cancer.

  9. A novel role of STAT3 (show STAT3 Antibodies)/miR (show MLXIP Antibodies)-21 axis and CDK5/CDK5R1 (p35 (show CDK5R1 Antibodies)) in metastasis of head and neck squamous cell carcinoma.

  10. A cyclin I (show CCNI Antibodies)-Cdk5 complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer.

Mouse (Murine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. The behavioral and molecular data indicated that TRPV1 (show TRPV1 Antibodies) is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/threonine406(rat).

  2. that Cdk5-dependent activation of neuronal inflammasomes was involved in the progression of Parkinson's disease

  3. we demonstrate that Cdk5 phosphorylates collapsin response mediator protein 2 (CRMP2 (show DPYSL2 Antibodies)) in the dendritic spines of cultured hippocampal neurons and in vivo in the mouse brain. When we eliminated CRMP2 (show DPYSL2 Antibodies) phosphorylation in CRMP2 (show DPYSL2 Antibodies)(KI/KI (show AXIN1 Antibodies)) mice, the densities of dendritic spines significantly decreased in hippocampal CA1 (show CA1 Antibodies) pyramidal neurons in the mouse brain.

  4. Results indicate that dendritic spine formation and neuronal maintenance are dependent on Cdk5 activity

  5. Data indicate a contribution of D2 dopamine receptors to the effects of repetitive transcranial magnetic stimulation (rTMS) on postsynaptic density protein-95 (PSD-95 (show DLG4 Antibodies)) and cyclin-dependent kinase 5 (CDK5) levels.

  6. olfactory deprivation by olfactory bulbectomy hastens tau pathology and cholinergic system impairment in htau mice possibly via activation of cdk5.

  7. The transiently active CDK5-p35 (show CDK5R1 Antibodies) complexes limited the LPS (show TLR4 Antibodies)-stimulated phosphorylation and activation of various mitogen-activated protein kinases (MAPKs), thereby preventing the premature production of SOCS3 (suppressor of cytokine signaling 3 (show SOCS3 Antibodies))

  8. this finding highlights a central role for Cdk5 in immune checkpoint regulation by tumor cells.

  9. Cdk5 (cyclin-dependent kinase 5) requires p35 (show CDK5R1 Antibodies) regulatory subunit (Cdk5r1 (show CDK5R1 Antibodies)) for activation; data suggest Cdk5r1 (show CDK5R1 Antibodies) stability regulates Cdk5 activity in neurons; Cdk5r1 (show CDK5R1 Antibodies) is rapidly degraded by 2 proteasome methods, ubiquitination-dependent and -independent.

  10. The findings of this study suggest that CDK5-depleted astrocytes act as a neuroprotective trophic source in a Rac1-dependent manner.

Cow (Bovine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. data indicate that PP1alpha (show PPP1CA Antibodies) is a downstream target of the NGF (show NGFB Antibodies)/Egr-1 (show EGR1 Antibodies)/Cdk5 pathway during NGF (show NGFB Antibodies)-induced differentiation of PC12 cells and suggest that PP1 (show PPYR1 Antibodies) phosphorylation promotes neuronal differentiation

Pig (Porcine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. CDK5-mediated hyperphosphorylation of SIRT1 (show SIRT1 Antibodies) facilitates the development of endothelial senescence and atherosclerosis.

  2. CDK5 mRNA reaches the highest level in cerebral cortex at two months of age and in cerebellum and liver at 4 months of age, respectively, whereas the peak level of CDK5R1 (show CDK5R1 Antibodies) was observed in both cerebral cortex and cerebellum at two months of age

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. These data show that Cdk5 regulates the onset and extent of remodeling of the Drosophila mushroom body.

  2. The CDK5 phosphorylates MEKK1 (show MAP3K1 Antibodies), and together, they activate the JNK (show MAPK8 Antibodies) pathway for apoptosis.

  3. The data of this study demonstrated that Cdk5/p35 (show RPLP0 Antibodies) kinase is a key regulator of the development and maintenance of the axon initial segment in Drosophila.

  4. Therefore, we propose that Abl and p35/p25 (show CDK5R1 Antibodies) cooperate in promoting Cdk5-pY15, which deregulates Cdk5 activity and subcellular localization in Abeta42-triggered neurodegeneration.

  5. Cdk5/p35 (show RPLP0 Antibodies) did not have major effects on tau toxicity or phosphorylation.

  6. In Drosophila the cdk5 is needed for locomotive behavior and NMJ elaboration.

Zebrafish Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. These results suggest that the phosphorylation of Dpysl2 (show DPYSL2 Antibodies) and Dpysl3 (show DPYSL3 Antibodies) by Cdk5 and DYRK2 (show DYRK2 Antibodies) is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.

  2. cdk5 mRNA was injected into the one- to two-cell embryos, in which neuron apoptosis was inhibited compared with the uninjected control embryos.

  3. we have cloned and characterized the zebrafish cdk5 ortholog. Zebrafish cdk5 is 96% identical to its human counterpart and expressed as early as the blastula stage.

  4. cdk5 plays a critical role in spinal and cranial motor neuron development.

CDK5 Antigen Profile

Antigen Summary

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity\; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells\; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.

Alternative names and synonyms associated with CDK5

  • cyclin-dependent kinase 5 (CDK5) antibody
  • cyclin-dependent kinase 5 (Cdk5) antibody
  • Cyclin-dependent kinase 5 (Cdk5) antibody
  • cyclin-dependent kinase 5 (cdk5) antibody
  • cyclin-dependent kinase 5 (LOC100352775) antibody
  • cyclin-dependent protein kinase 5 (cdk5) antibody
  • AW048668 antibody
  • cdk5 antibody
  • CG8203 antibody
  • Crk6 antibody
  • DmCdk5 antibody
  • Dmel\\CG8203 antibody
  • PSSALRE antibody
  • zgc:101604 antibody

Protein level used designations for CDK5

TPKII catalytic subunit , cell division protein kinase 5 , protein kinase CDK5 splicing , serine/threonine-protein kinase PSSALRE , tau protein kinase II catalytic subunit , CR6 protein kinase , PDPK , proline-directed protein kinase 33 kDa subunit , CG8203-PA , Cdk5-PA , neuronal cyclin-dependent kinase 5

GENE ID SPECIES
1020 Homo sapiens
12568 Mus musculus
140908 Rattus norvegicus
281066 Bos taurus
100190948 Gallus gallus
475537 Canis lupus familiaris
733700 Sus scrofa
36727 Drosophila melanogaster
399296 Xenopus laevis
100732840 Cavia porcellus
100190973 Ovis aries
100352775 Oryctolagus cuniculus
65234 Danio rerio
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