Browse our anti-CDK5 (CDK5) Antibodies

Full name:
anti-Cyclin-Dependent Kinase 5 Antibodies (CDK5)
On www.antibodies-online.com are 241 Cyclin-Dependent Kinase 5 (CDK5) Antibodies from 27 different suppliers available. Additionally we are shipping CDK5 Kits (50) and CDK5 Proteins (19) and many more products for this protein. A total of 323 CDK5 products are currently listed.
Synonyms:
AW048668, cdk5, CG8203, Crk6, DmCdk5, Dmel\\CG8203, PSSALRE, zgc:101604

Most Popular Reactivities for anti-CDK5 (CDK5) Antibodies

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anti-Human CDK5 Antibodies:

anti-Mouse (Murine) CDK5 Antibodies:

anti-Rat (Rattus) CDK5 Antibodies:

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Top referenced anti-CDK5 Antibodies

  1. Human Monoclonal CDK5 Primary Antibody for IF, IP - ABIN115138 : Matsushime, Roussel, Ashmun, Sherr: Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. in Cell 1991 (PubMed)
    Show all 4 references for 115138

  2. Human Polyclonal CDK5 Primary Antibody for IF (p), IHC (p) - ABIN670101 : Yin, Qi, Ren, Wang, Jiang, Feng, Cui: Roscovitine treatment caused impairment of fertilizing ability in mice. in Toxicology letters 2015 (PubMed)
    Show all 3 references for 670101

  3. Human Monoclonal CDK5 Primary Antibody for WB - ABIN1945087 : Meyerson, Enders, Wu, Su, Gorka, Nelson, Harlow, Tsai: A family of human cdc2-related protein kinases. in The EMBO journal 1992 (PubMed)
    Show all 2 references for 1945087

  4. Human Monoclonal CDK5 Primary Antibody for ICC, FACS - ABIN969041 : Zhang, Herrup: Cdk5 and the non-catalytic arrest of the neuronal cell cycle. in Cell cycle (Georgetown, Tex.) 2008 (PubMed)
    Show all 2 references for 969041

  5. Human Monoclonal CDK5 Primary Antibody for WB - ABIN1944859 : Li, Liu, Zhang, Ye, Qiao, Ling, Wu, Zhang, Yu: Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling. in Molecular biology reports 2010 (PubMed)
    Show all 2 references for 1944859

  6. Cow (Bovine) Polyclonal CDK5 Primary Antibody for IHC, WB - ABIN2780626 : Otyepka, Bártová, Kríz, Koca: Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics. in The Journal of biological chemistry 2006 (PubMed)

  7. Cow (Bovine) Polyclonal CDK5 Primary Antibody for WB - ABIN2792160 : Liu, Tian, Gearing, Hunter, Ye, Mao: Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Antibodies against CDK5 Interaction Partners

Human Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. conditional inactivation of Cdk5 in the jck (show NEK8 Antibodies) mice significantly attenuates cystic disease progression and is associated with shortening of ciliary length as well as restoration of cellular differentiation. Our results suggest that CDK5 may regulate ciliary length by affecting tubulin (show TUBB Antibodies) dynamics via its substrate collapsin response mediator protein 2 (show DPYSL2 Antibodies).

  2. CRM1 (show XPO1 Antibodies) and CDK5 co-expression was an independent prognostic factors for gastric cancer (GC). Combined CRM1 (show XPO1 Antibodies) and CDK5 expression could provide a prognostic model for overall survival of GC.

  3. Studies indicate evidence for cyclin dependent kinase 5 (CDK5) in contributing to the onset and progression of tumorigenesis.

  4. this study revealed the functional and mechanistic links between CDK5 and the oncogenic ERK5 (show MAPK7 Antibodies)-AP-1 (show FOSB Antibodies) signaling pathway in the pathogenesis of colorectal cancer.

  5. the silencing of Cyclin-dependent kinase 5 preventing memory dysfunction

  6. Increased CDK5 expression is associated with breast cancer.

  7. It is shown that p5 binds the kinase at the same CDK5/p25 (show LCN2 Antibodies) and CDK5/p35 (show ANXA1 Antibodies) interfaces, and is thus a non-selective competitor of both activators, in agreement with available experimental data in vitro.

  8. the activated CDK5 kinase is involved in the EZH2 (show EZH2 Antibodies) phosphorylation that is required for FBW7 (show FBXW7 Antibodies)-mediated degradation.

  9. we supposed that EphA4 (show EPHA4 Antibodies) interacted with CDK5 and promoted its expression which in turn enhanced p-AKT (show AKT1 Antibodies) expression and promoted cell adhesion-mediated drug resistance in multiple myeloma.

  10. the minor allele of CDK5R1 (show CDK5R1 Antibodies) 3'-UTR (show UTS2R Antibodies) rs735555 polymorphism was associated with increased risk for NS-ID. In conclusion, our data suggest that mutations and polymorphisms in CDK5 and CDK5R1 (show CDK5R1 Antibodies) genes may contribute to the onset of the NS-ID phenotype

Mouse (Murine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. conditional inactivation of Cdk5 in the jck (show NEK8 Antibodies) mice significantly attenuates cystic disease progression and is associated with shortening of ciliary length as well as restoration of cellular differentiation. Our results suggest that CDK5 may regulate ciliary length by affecting tubulin (show TUBB Antibodies) dynamics via its substrate collapsin response mediator protein 2 (show DPYSL2 Antibodies).

  2. Silencing of CDK5 increased BDNF (show BDNF Antibodies) expression, temporarily increased phosphorylation of CaMKII (show CAMK2G Antibodies), ERK (show EPHB2 Antibodies), and CREB (show CREB1 Antibodies); and facilitated calcium signaling in neurites. Together, these data suggest that CDK5 downregulation induces synaptic plasticity in mature neurons involving Ca(2 (show CA2 Antibodies)+) signaling and BDNF (show BDNF Antibodies)/CREB (show CREB1 Antibodies) activation.

  3. we report a key role for Cdk5 activity in the development of allogeneic T-cell responses after allogeneic hematopoietic cell transplantation

  4. Cdk5 regulates axon outgrowth through the GRAB-mediated Rab8-Rab11 cascade.

  5. these results show that Cdk5-mediated phospho-regulation of Foxo3 (show FOXO3 Antibodies) can activate several genes that promote neuronal death and aberrant Abeta (show APP Antibodies) processing, thereby contributing to the progression of neurodegenerative pathologies.

  6. In this study, we discovered that selective upregulation of p39 (show ATP6V0D1 Antibodies) is the underlying mechanism that accommodates the increased functional requirement of Cdk5 activation during neuronal differentiation. In addition, we demonstrated that p39 (show ATP6V0D1 Antibodies) selectively directs Cdk5 to phosphorylate protein substrates essential for axonal development, dendritic spine formation, and synaptogenesis. Moreover, our studies suggest opposing roles o

  7. It suggests that ectopic increase of Cdk5 kinase activity through conversion of p35 to p25 is involved in the process of neuronal death induced by hypoxia.

  8. The behavioral and molecular data indicated that TRPV1 (show TRPV1 Antibodies) is strongly modulated by Cdk5-mediated phosphorylation at position threonine-407(mouse)/threonine406(rat).

  9. that Cdk5-dependent activation of neuronal inflammasomes was involved in the progression of Parkinson's disease

  10. we demonstrate that Cdk5 phosphorylates collapsin response mediator protein 2 (CRMP2 (show DPYSL2 Antibodies)) in the dendritic spines of cultured hippocampal neurons and in vivo in the mouse brain. When we eliminated CRMP2 (show DPYSL2 Antibodies) phosphorylation in CRMP2 (show DPYSL2 Antibodies)(KI/KI (show AXIN1 Antibodies)) mice, the densities of dendritic spines significantly decreased in hippocampal CA1 (show CA1 Antibodies) pyramidal neurons in the mouse brain.

Cow (Bovine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. data indicate that PP1alpha (show PPP1CA Antibodies) is a downstream target of the NGF (show NGFB Antibodies)/Egr-1 (show EGR1 Antibodies)/Cdk5 pathway during NGF (show NGFB Antibodies)-induced differentiation of PC12 cells and suggest that PP1 (show PPYR1 Antibodies) phosphorylation promotes neuronal differentiation

Pig (Porcine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. CDK5-mediated hyperphosphorylation of SIRT1 (show SIRT1 Antibodies) facilitates the development of endothelial senescence and atherosclerosis.

  2. CDK5 mRNA reaches the highest level in cerebral cortex at two months of age and in cerebellum and liver at 4 months of age, respectively, whereas the peak level of CDK5R1 (show CDK5R1 Antibodies) was observed in both cerebral cortex and cerebellum at two months of age

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. These data show that Cdk5 regulates the onset and extent of remodeling of the Drosophila mushroom body.

  2. The CDK5 phosphorylates MEKK1 (show MAP3K1 Antibodies), and together, they activate the JNK (show MAPK8 Antibodies) pathway for apoptosis.

  3. The data of this study demonstrated that Cdk5/p35 (show RPLP0 Antibodies) kinase is a key regulator of the development and maintenance of the axon initial segment in Drosophila.

  4. Therefore, we propose that Abl and p35/p25 (show CDK5R1 Antibodies) cooperate in promoting Cdk5-pY15, which deregulates Cdk5 activity and subcellular localization in Abeta42-triggered neurodegeneration.

  5. Cdk5/p35 (show RPLP0 Antibodies) did not have major effects on tau toxicity or phosphorylation.

  6. In Drosophila the cdk5 is needed for locomotive behavior and NMJ elaboration.

Zebrafish Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. The intrahepatic biliary network is a highly branched three-dimensional network lined by biliary epithelial cells. We designed a new computer-based algorithm that quantitatively computes the structural differences of the three-dimensional networks. Utilizing the algorithm, we showed that inhibition of Cyclin-dependent kinase 5 (Cdk5) led to reduced branching in the intrahepatic biliary network.

  2. These results suggest that the phosphorylation of Dpysl2 (show DPYSL2 Antibodies) and Dpysl3 (show DPYSL3 Antibodies) by Cdk5 and DYRK2 (show DYRK2 Antibodies) is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.

  3. cdk5 mRNA was injected into the one- to two-cell embryos, in which neuron apoptosis was inhibited compared with the uninjected control embryos.

  4. we have cloned and characterized the zebrafish cdk5 ortholog. Zebrafish cdk5 is 96% identical to its human counterpart and expressed as early as the blastula stage.

  5. cdk5 plays a critical role in spinal and cranial motor neuron development.

CDK5 Antigen Profile

Antigen Summary

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity\; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells\; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.

Alternative names and synonyms associated with CDK5

  • cyclin-dependent kinase 5 (CDK5) antibody
  • cyclin-dependent kinase 5 (Cdk5) antibody
  • Cyclin-dependent kinase 5 (Cdk5) antibody
  • cyclin-dependent kinase 5 (cdk5) antibody
  • cyclin-dependent kinase 5 (LOC100352775) antibody
  • cyclin-dependent protein kinase 5 (cdk5) antibody
  • AW048668 antibody
  • cdk5 antibody
  • CG8203 antibody
  • Crk6 antibody
  • DmCdk5 antibody
  • Dmel\\CG8203 antibody
  • PSSALRE antibody
  • zgc:101604 antibody

Protein level used designations for CDK5

TPKII catalytic subunit , cell division protein kinase 5 , protein kinase CDK5 splicing , serine/threonine-protein kinase PSSALRE , tau protein kinase II catalytic subunit , CR6 protein kinase , PDPK , proline-directed protein kinase 33 kDa subunit , CG8203-PA , Cdk5-PA , neuronal cyclin-dependent kinase 5

GENE ID SPECIES
1020 Homo sapiens
12568 Mus musculus
140908 Rattus norvegicus
281066 Bos taurus
100190948 Gallus gallus
475537 Canis lupus familiaris
733700 Sus scrofa
36727 Drosophila melanogaster
399296 Xenopus laevis
100732840 Cavia porcellus
100190973 Ovis aries
100352775 Oryctolagus cuniculus
65234 Danio rerio
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