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Browse our anti-CDK5 (CDK5) Antibodies

Full name:
anti-Cyclin-Dependent Kinase 5 Antibodies (CDK5)
On are 219 Cyclin-Dependent Kinase 5 (CDK5) Antibodies from 26 different suppliers available. Additionally we are shipping CDK5 Kits (49) and CDK5 Proteins (14) and many more products for this protein. A total of 297 CDK5 products are currently listed.
AW048668, cdk5, CG8203, Crk6, DmCdk5, Dmel\\CG8203, PSSALRE, zgc:101604

Most Popular Reactivities for anti-CDK5 (CDK5) Antibodies

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anti-Human CDK5 Antibodies:

anti-Mouse (Murine) CDK5 Antibodies:

anti-Rat (Rattus) CDK5 Antibodies:

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Top referenced anti-CDK5 Antibodies

  1. Human Monoclonal CDK5 Primary Antibody for IF, IP - ABIN115138 : Matsushime, Roussel, Ashmun, Sherr: Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. in Cell 1991 (PubMed)
    Show all 4 references for ABIN115138

  2. Human Monoclonal CDK5 Primary Antibody for IHC (fro), WB - ABIN782438 : Nguyen, Bibb: Cdk5 and the mystery of synaptic vesicle endocytosis. in The Journal of cell biology 2003 (PubMed)
    Show all 4 references for ABIN782438

  3. Human Monoclonal CDK5 Primary Antibody for ICC, FACS - ABIN969041 : Zhang, Herrup: Cdk5 and the non-catalytic arrest of the neuronal cell cycle. in Cell cycle (Georgetown, Tex.) 2008 (PubMed)
    Show all 2 references for ABIN969041

  4. Human Monoclonal CDK5 Primary Antibody for WB - ABIN1944859 : Meyerson, Enders, Wu, Su, Gorka, Nelson, Harlow, Tsai: A family of human cdc2-related protein kinases. in The EMBO journal 1992 (PubMed)
    Show all 2 references for ABIN1944859

  5. Human Monoclonal CDK5 Primary Antibody for WB - ABIN1945087 : Li, Liu, Zhang, Ye, Qiao, Ling, Wu, Zhang, Yu: Characterization of a novel human CDK5 splicing variant that inhibits Wnt/beta-catenin signaling. in Molecular biology reports 2010 (PubMed)
    Show all 2 references for ABIN1945087

  6. Human Polyclonal CDK5 Primary Antibody for IF (p), IHC (p) - ABIN872301 : Yin, Qi, Ren, Wang, Jiang, Feng, Cui: Roscovitine treatment caused impairment of fertilizing ability in mice. in Toxicology letters 2015 (PubMed)

  7. Chicken Polyclonal CDK5 Primary Antibody for IHC, WB - ABIN2780626 : Otyepka, Bártová, Kríz, Koca: Different mechanisms of CDK5 and CDK2 activation as revealed by CDK5/p25 and CDK2/cyclin A dynamics. in The Journal of biological chemistry 2006 (PubMed)

  8. Chicken Polyclonal CDK5 Primary Antibody for WB - ABIN2792160 : Liu, Tian, Gearing, Hunter, Ye, Mao: Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

More Antibodies against CDK5 Interaction Partners

Human Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. A novel role of STAT3 (show STAT3 Antibodies)/miR (show MLXIP Antibodies)-21 axis and CDK5/CDK5R1 (p35 (show CDK5R1 Antibodies)) in metastasis of head and neck squamous cell carcinoma.

  2. A cyclin I (show CCNI Antibodies)-Cdk5 complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer.

  3. These results for the first time demonstrate a role of Cdk5/p35 (show ANXA1 Antibodies) in the regulation of cell cycle progression modulated by TGF-beta1 (show TGFB1 Antibodies).

  4. Data show that cyclin-dependent kinase 5 (Cdk5) could phosphorylate the adjacent S1627 in the leucine-rich repeat kinase 2 (LRRK2 (show LRRK2 Antibodies)) R1628P mutant.

  5. These p35 (show ANXA1 Antibodies) mutations are unlikely to cause mental retardation.

  6. These data identify a novel oncogenic mechanism where CDK5 activation induces CRMP2A (show DPYSL2 Antibodies) phosphorylation in the nuclei of tumour cells

  7. Increased expression of CDK5 infers poor outcomes for nasopharyngeal carcinoma patients.

  8. Results reveal a link between p25 (show LCN2 Antibodies) and BACE1 (show BACE Antibodies) in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 activation by p25 (show LCN2 Antibodies) accelerates AD pathogenesis by enhancing BACE1 (show BACE Antibodies) activity via phosphorylation.

  9. Data indicate that combining the CDK (show CDK4 Antibodies) inhibitor dinaciclib with the pan (show SUPT6H Antibodies)-AKT (show AKT1 Antibodies) inhibitor MK-2206 showed promising therapeutic results in pancreatic cancer murine model.

  10. Functional inhibition of CDK5 using roscovitine and siRNA markedly suppressed the proliferation of A549 cells and resulted in a reduced tumor mass in vivo.

Mouse (Murine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. The transiently active CDK5-p35 (show CDK5R1 Antibodies) complexes limited the LPS (show TLR4 Antibodies)-stimulated phosphorylation and activation of various mitogen-activated protein kinases (MAPKs), thereby preventing the premature production of SOCS3 (suppressor of cytokine signaling 3 (show SOCS3 Antibodies))

  2. this finding highlights a central role for Cdk5 in immune checkpoint regulation by tumor cells.

  3. Cdk5 (cyclin-dependent kinase 5) requires p35 (show CDK5R1 Antibodies) regulatory subunit (Cdk5r1 (show CDK5R1 Antibodies)) for activation; data suggest Cdk5r1 (show CDK5R1 Antibodies) stability regulates Cdk5 activity in neurons; Cdk5r1 (show CDK5R1 Antibodies) is rapidly degraded by 2 proteasome methods, ubiquitination-dependent and -independent.

  4. The findings of this study suggest that CDK5-depleted astrocytes act as a neuroprotective trophic source in a Rac1-dependent manner.

  5. phosphorylation of coronin 1 on Thr (show TRH Antibodies)(418/424) by cyclin-dependent kinase (show CDK1 Antibodies) (CDK) 5 activity was responsible for coronin 1-Galphas (show GNAS Antibodies) association and the modulation of cAMP production

  6. Nitric oxide -induced reduction in Cdk5 activity is mediated by S-nitrosylation of p35 (show CDK5R1 Antibodies), resulting in its ubiquitination and degradation by the E3 ligase PJA2 (show PJA2 Antibodies).

  7. conditional deletion of CDK5 significantly attenuates DRP1 (show CRMP1 Antibodies) phosphorylation at S585 and rescues mitochondrial fission defects in neurons exposed to NMDA.

  8. Cdk5 regulates lymphatic vessel formation and function via phosphorylation of Foxc2 (show FOXC2 Antibodies). Endothelial-specific Cdk5 knockdown causes congenital lymphatic dysfunction and lymphedema due to defective lymphatic vessel patterning and valve formation.

  9. Acute stress (AS) caused a biphasic effect on CDK5 activity, initially reducing but increasing afterwards in prefrontal cortex and hippocampus, whereas chronic unpredictable stress (CS) strongly increased it in these brain areas.

  10. Cdk5 modulates gene expression during T-cell activation by impairing the repression of gene transcription by histone deacetylase 1 (HDAC1 (show HDAC1 Antibodies)) through specific phosphorylation of the mSin3a protein at serine residue 861.

Cow (Bovine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. data indicate that PP1alpha (show PPP1CA Antibodies) is a downstream target of the NGF (show NGFB Antibodies)/Egr-1 (show EGR1 Antibodies)/Cdk5 pathway during NGF (show NGFB Antibodies)-induced differentiation of PC12 cells and suggest that PP1 (show PPYR1 Antibodies) phosphorylation promotes neuronal differentiation

Pig (Porcine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. CDK5-mediated hyperphosphorylation of SIRT1 (show SIRT1 Antibodies) facilitates the development of endothelial senescence and atherosclerosis.

  2. CDK5 mRNA reaches the highest level in cerebral cortex at two months of age and in cerebellum and liver at 4 months of age, respectively, whereas the peak level of CDK5R1 (show CDK5R1 Antibodies) was observed in both cerebral cortex and cerebellum at two months of age

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. The CDK5 phosphorylates MEKK1 (show MAP3K1 Antibodies), and together, they activate the JNK (show MAPK8 Antibodies) pathway for apoptosis.

  2. The data of this study demonstrated that Cdk5/p35 (show RPLP0 Antibodies) kinase is a key regulator of the development and maintenance of the axon initial segment in Drosophila.

  3. Therefore, we propose that Abl and p35/p25 (show CDK5R1 Antibodies) cooperate in promoting Cdk5-pY15, which deregulates Cdk5 activity and subcellular localization in Abeta42-triggered neurodegeneration.

  4. Cdk5/p35 (show RPLP0 Antibodies) did not have major effects on tau toxicity or phosphorylation.

  5. In Drosophila the cdk5 is needed for locomotive behavior and NMJ elaboration.

Zebrafish Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. These results suggest that the phosphorylation of Dpysl2 (show DPYSL2 Antibodies) and Dpysl3 (show DPYSL3 Antibodies) by Cdk5 and DYRK2 (show DYRK2 Antibodies) is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.

  2. cdk5 mRNA was injected into the one- to two-cell embryos, in which neuron apoptosis was inhibited compared with the uninjected control embryos.

  3. we have cloned and characterized the zebrafish cdk5 ortholog. Zebrafish cdk5 is 96% identical to its human counterpart and expressed as early as the blastula stage.

  4. cdk5 plays a critical role in spinal and cranial motor neuron development.

CDK5 Antigen Profile

Antigen Summary

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity\; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells\; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.

Alternative names and synonyms associated with CDK5

  • cyclin-dependent kinase 5 (CDK5) antibody
  • cyclin-dependent kinase 5 (Cdk5) antibody
  • Cyclin-dependent kinase 5 (Cdk5) antibody
  • cyclin-dependent kinase 5 (cdk5) antibody
  • cyclin-dependent kinase 5 (LOC100352775) antibody
  • cyclin-dependent protein kinase 5 (cdk5) antibody
  • AW048668 antibody
  • cdk5 antibody
  • CG8203 antibody
  • Crk6 antibody
  • DmCdk5 antibody
  • Dmel\\CG8203 antibody
  • PSSALRE antibody
  • zgc:101604 antibody

Protein level used designations for CDK5

TPKII catalytic subunit , cell division protein kinase 5 , protein kinase CDK5 splicing , serine/threonine-protein kinase PSSALRE , tau protein kinase II catalytic subunit , CR6 protein kinase , PDPK , proline-directed protein kinase 33 kDa subunit , CG8203-PA , Cdk5-PA , neuronal cyclin-dependent kinase 5

1020 Homo sapiens
12568 Mus musculus
140908 Rattus norvegicus
281066 Bos taurus
100190948 Gallus gallus
475537 Canis lupus familiaris
733700 Sus scrofa
36727 Drosophila melanogaster
399296 Xenopus laevis
100732840 Cavia porcellus
100190973 Ovis aries
100352775 Oryctolagus cuniculus
65234 Danio rerio
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