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Browse our CDK5 Proteins (CDK5)

Full name:
Cyclin-Dependent Kinase 5 Proteins (CDK5)
On are 14 Cyclin-Dependent Kinase 5 (CDK5) Proteins from 10 different suppliers available. Additionally we are shipping CDK5 Antibodies (219) and CDK5 Kits (50) and many more products for this protein. A total of 298 CDK5 products are currently listed.
AW048668, cdk5, CG8203, Crk6, DmCdk5, Dmel\\CG8203, PSSALRE, zgc:101604
list all proteins Gene Name GeneID UniProt
CDK5 1020 Q00535
CDK5 12568 P49615
Rat CDK5 CDK5 140908 Q03114

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CDK5 Proteins (CDK5) by Origin

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Top referenced CDK5 Proteins

  1. Human CDK5 Protein expressed in Escherichia coli (E. coli) - ABIN1098713 : Demetrick, Zhang, Beach: Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. in Cytogenetics and cell genetics 1994 (PubMed)
    Show all 2 references for ABIN1098713

  2. Human CDK5 Protein expressed in Wheat germ - ABIN1348956 : Seo, Kim, Bae, Soh, Lee: Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1. in The Journal of biological chemistry 2008 (PubMed)

  3. Human CDK5 Protein expressed in Baculovirus infected Insect Cells - ABIN2003568 : Mapelli, Musacchio: The structural perspective on CDK5. in Neuro-Signals 2003 (PubMed)

More Proteins for CDK5 Interaction Partners

Human Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. Cdk5-mediated phosphorylation of CHIP negatively regulates its neuroprotective function, thereby contributing to neuronal cell death progression following neurotoxic stimuli.

  2. High cyclin-dependent kinase 5 expression is associated with non-small cell lung cancer and small cell lung cancer.

  3. A novel role of STAT3 (show STAT3 Proteins)/miR (show MLXIP Proteins)-21 axis and CDK5/CDK5R1 (p35 (show CDK5R1 Proteins)) in metastasis of head and neck squamous cell carcinoma.

  4. A cyclin I (show CCNI Proteins)-Cdk5 complex forms a critical antiapoptotic factor in the process of generating cisplatin resistance in cervical cancer.

  5. These results for the first time demonstrate a role of Cdk5/p35 (show ANXA1 Proteins) in the regulation of cell cycle progression modulated by TGF-beta1 (show TGFB1 Proteins).

  6. Data show that cyclin-dependent kinase 5 (Cdk5) could phosphorylate the adjacent S1627 in the leucine-rich repeat kinase 2 (LRRK2 (show LRRK2 Proteins)) R1628P mutant.

  7. These p35 (show ANXA1 Proteins) mutations are unlikely to cause mental retardation.

  8. These data identify a novel oncogenic mechanism where CDK5 activation induces CRMP2A (show DPYSL2 Proteins) phosphorylation in the nuclei of tumour cells

  9. Increased expression of CDK5 infers poor outcomes for nasopharyngeal carcinoma patients.

  10. Results reveal a link between p25 (show LCN2 Proteins) and BACE1 (show BACE Proteins) in Alzheimer disease (AD) brains and suggest that upregulated Cdk5 activation by p25 (show LCN2 Proteins) accelerates AD pathogenesis by enhancing BACE1 (show BACE Proteins) activity via phosphorylation.

Mouse (Murine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. Data indicate a contribution of D2 dopamine receptors to the effects of repetitive transcranial magnetic stimulation (rTMS) on postsynaptic density protein-95 (PSD-95 (show DLG4 Proteins)) and cyclin-dependent kinase 5 (CDK5) levels.

  2. olfactory deprivation by olfactory bulbectomy hastens tau pathology and cholinergic system impairment in htau mice possibly via activation of cdk5.

  3. The transiently active CDK5-p35 (show CDK5R1 Proteins) complexes limited the LPS (show TLR4 Proteins)-stimulated phosphorylation and activation of various mitogen-activated protein kinases (MAPKs), thereby preventing the premature production of SOCS3 (suppressor of cytokine signaling 3 (show SOCS3 Proteins))

  4. this finding highlights a central role for Cdk5 in immune checkpoint regulation by tumor cells.

  5. Cdk5 (cyclin-dependent kinase 5) requires p35 (show CDK5R1 Proteins) regulatory subunit (Cdk5r1 (show CDK5R1 Proteins)) for activation; data suggest Cdk5r1 (show CDK5R1 Proteins) stability regulates Cdk5 activity in neurons; Cdk5r1 (show CDK5R1 Proteins) is rapidly degraded by 2 proteasome methods, ubiquitination-dependent and -independent.

  6. The findings of this study suggest that CDK5-depleted astrocytes act as a neuroprotective trophic source in a Rac1-dependent manner.

  7. phosphorylation of coronin 1 on Thr (show TRH Proteins)(418/424) by cyclin-dependent kinase (show CDK1 Proteins) (CDK) 5 activity was responsible for coronin 1-Galphas (show GNAS Proteins) association and the modulation of cAMP production

  8. Nitric oxide -induced reduction in Cdk5 activity is mediated by S-nitrosylation of p35 (show CDK5R1 Proteins), resulting in its ubiquitination and degradation by the E3 ligase PJA2 (show PJA2 Proteins).

  9. conditional deletion of CDK5 significantly attenuates DRP1 phosphorylation at S585 and rescues mitochondrial fission defects in neurons exposed to NMDA.

  10. Cdk5 regulates lymphatic vessel formation and function via phosphorylation of Foxc2 (show FOXC2 Proteins). Endothelial-specific Cdk5 knockdown causes congenital lymphatic dysfunction and lymphedema due to defective lymphatic vessel patterning and valve formation.

Cow (Bovine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. data indicate that PP1alpha (show PPP1CA Proteins) is a downstream target of the NGF (show NGFB Proteins)/Egr-1 (show EGR1 Proteins)/Cdk5 pathway during NGF (show NGFB Proteins)-induced differentiation of PC12 cells and suggest that PP1 (show PPYR1 Proteins) phosphorylation promotes neuronal differentiation

Pig (Porcine) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. CDK5-mediated hyperphosphorylation of SIRT1 (show SIRT1 Proteins) facilitates the development of endothelial senescence and atherosclerosis.

  2. CDK5 mRNA reaches the highest level in cerebral cortex at two months of age and in cerebellum and liver at 4 months of age, respectively, whereas the peak level of CDK5R1 (show CDK5R1 Proteins) was observed in both cerebral cortex and cerebellum at two months of age

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. These data show that Cdk5 regulates the onset and extent of remodeling of the Drosophila mushroom body.

  2. The CDK5 phosphorylates MEKK1 (show MAP3K1 Proteins), and together, they activate the JNK (show MAPK8 Proteins) pathway for apoptosis.

  3. The data of this study demonstrated that Cdk5/p35 (show RPLP0 Proteins) kinase is a key regulator of the development and maintenance of the axon initial segment in Drosophila.

  4. Therefore, we propose that Abl and p35/p25 (show CDK5R1 Proteins) cooperate in promoting Cdk5-pY15, which deregulates Cdk5 activity and subcellular localization in Abeta42-triggered neurodegeneration.

  5. Cdk5/p35 (show RPLP0 Proteins) did not have major effects on tau toxicity or phosphorylation.

  6. In Drosophila the cdk5 is needed for locomotive behavior and NMJ elaboration.

Zebrafish Cyclin-Dependent Kinase 5 (CDK5) interaction partners

  1. These results suggest that the phosphorylation of Dpysl2 (show DPYSL2 Proteins) and Dpysl3 (show DPYSL3 Proteins) by Cdk5 and DYRK2 (show DYRK2 Proteins) is required for the proper positioning of Rohon-Beard neurons and neural crest cells during neurulation in zebrafish embryos.

  2. cdk5 mRNA was injected into the one- to two-cell embryos, in which neuron apoptosis was inhibited compared with the uninjected control embryos.

  3. we have cloned and characterized the zebrafish cdk5 ortholog. Zebrafish cdk5 is 96% identical to its human counterpart and expressed as early as the blastula stage.

  4. cdk5 plays a critical role in spinal and cranial motor neuron development.

CDK5 Protein Profile

Protein Summary

Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3- type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocytes differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Activated by interaction with CDK5R1 (p35) and ATP6V0D1 (p39), especially in post-mitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Phosphorylates also exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and PCTAIRE 1/CDK16 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity\; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicites cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells\; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma- dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin- dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1- EPHA4 signaling.

Alternative names and synonyms associated with CDK5

  • cyclin-dependent kinase 5 (CDK5)
  • cyclin-dependent kinase 5 (Cdk5)
  • Cyclin-dependent kinase 5 (Cdk5)
  • cyclin-dependent kinase 5 (cdk5)
  • cyclin-dependent kinase 5 (LOC100352775)
  • cyclin-dependent protein kinase 5 (cdk5)
  • AW048668 protein
  • cdk5 protein
  • CG8203 protein
  • Crk6 protein
  • DmCdk5 protein
  • Dmel\\CG8203 protein
  • PSSALRE protein
  • zgc:101604 protein

Protein level used designations for CDK5

TPKII catalytic subunit , cell division protein kinase 5 , protein kinase CDK5 splicing , serine/threonine-protein kinase PSSALRE , tau protein kinase II catalytic subunit , CR6 protein kinase , PDPK , proline-directed protein kinase 33 kDa subunit , CG8203-PA , Cdk5-PA , neuronal cyclin-dependent kinase 5

1020 Homo sapiens
12568 Mus musculus
140908 Rattus norvegicus
281066 Bos taurus
100190948 Gallus gallus
475537 Canis lupus familiaris
733700 Sus scrofa
36727 Drosophila melanogaster
399296 Xenopus laevis
100732840 Cavia porcellus
100190973 Ovis aries
100352775 Oryctolagus cuniculus
65234 Danio rerio
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