Browse our CDKN1C Proteins (CDKN1C)

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Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) Proteins (CDKN1C)
On are 3 Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) Proteins from 2 different suppliers available. Additionally we are shipping CDKN1C Antibodies (272) and CDKN1C Kits (5) and many more products for this protein. A total of 290 CDKN1C products are currently listed.
AL024410, BWCR, BWS, cb961, CDKI, DFNB48, Kip2, p27Xic1-a, p57, p57(kip2), p57Kip2, USH1J, WBS, zgc:86618
list all proteins Gene Name GeneID UniProt
CDKN1C 10518 O75838
Rat CDKN1C CDKN1C 246060  
CDKN1C 12577 P49919

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CDKN1C Proteins (CDKN1C) by Origin

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More Proteins for CDKN1C Interaction Partners

Human Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) interaction partners

  1. Data provide evidence that SLC22A18 and/or CDKN1C are tumor modifier genes involved in the tumorigenesis of SDHD (show SDHD Proteins)-mutated paraganglioma.

  2. The differences in p18(INK4c (show CDKN2C Proteins))and p57(Kip2)activities in chronic myeloid leukemia (show BCL11A Proteins) and normal stem cells suggest a different cell cycle regulation.

  3. The data has been provided on fetal growth patterns and on the molecular subtypes of Beckwith-Wiedemann syndrome, including gain or loss of DNA methylation (show HELLS Proteins), 11p15.5 paternal uniparental disomy, and CDKN1C mutation.

  4. Analysis of the chromatin status of Cdkn1c promoter and KvDMR1 in unresponsive compared to responsive cell types showed that their differential responsiveness to the MyoD (show MYOD1 Proteins)-dependent induction of the gene does not involve just their methylation status but, rather, the differential H3 lysine 9 dimethylation at KvDMR1.

  5. CDKN1C protein expression in the BM of newly diagnosed, treatment-naive MDS (show PAFAH1B1 Proteins) and secondary AML (show RUNX1 Proteins) patients was identified as a prognostic factor for poor survival in patients treated with antiproliferative chemotherapy.

  6. Low P57KIP2 Expression is associated with Hydatidiform Moles.

  7. These results indicate that the inhibitory effect of rapamycin may be due mainly to increased p14 (show S100A9 Proteins), p15 (show CDKN2B Proteins), and p57 expression via promoter demethylation and decreased mTOR (show FRAP1 Proteins) and p70S6K (show RPS6KB1 Proteins) expression in ALL cell lines.

  8. Jab1/Csn5 (show COPS5 Proteins) expression with concurrent low p57 expression associated with poor overall survival in hepatocellular carcinoma

  9. We identified a novel variant (rs7164338) on chromosome 15q25.1 in the CIB2 associated with lower pulse wave velocity.

  10. CIB2 (Calcium and Integrin Binding Protein (show CIB1 Proteins) 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family

Zebrafish Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) interaction partners

  1. Myod (show MYOD1 Proteins) in turn up-regulates cdkn1c, thereby providing a positive feedback loop that switches myogenic cells to terminal differentiation

  2. p57Kip2 is both necessary and sufficient to mediate Shh (show SHH Proteins)-induced cell-cycle exit in the deveoping zebrafish retina.

  3. during late embryogenesis, neural cells that have low but functional levels of Cdkn1c, regulated by Notch (show NOTCH1 Proteins) activity, are specified for oligodendrocyte fate

Cow (Bovine) Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) interaction partners

  1. Methylation of KvDMR1 involved in regulating the imprinting of CDKN1C

  2. proper expression levels of the imprinted genes CDKN1C and PHLDA2 (show PHLDA2 Proteins) are critical for embryo development

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) interaction partners

  1. This is the first report linking elevated Cdkn1c to altered behaviour in mice. Importantly, the findings from our study may have relevance for Silver Russell Syndrome and highlight a potentially underreported aspect of this disorder.

  2. Dnmt3a (show DNMT3A Proteins)-cKO muscles exhibit fewer Pax7 (show PAX7 Proteins)+ SCs (show TWIST1 Proteins), which show increased expression of p57Kip2 protein

  3. indicate that the effects of insulin-like growth factor 2 (IGF2 (show IGF2 Proteins)) are mediated by direct upregulation of the cyclin-dependent kinase inhibitor p57 (p57).

  4. Data show that transforming growth factor beta (TGFbeta (show TGFB1 Proteins))-induced changes in Gata2 transcription factor (show GATA2 Proteins) and cyclin-dependent kinase inhibitor 1C (P57) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 Proteins) signaling via Smad4 protein (show SMAD4 Proteins).

  5. This study reveals a key requirement for Cdkn1c in the early development of the brown adipose lineages.

  6. Lhx6 (show LHX6 Proteins) and Lhx8 (show LHX8 Proteins) promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2

  7. hepatoblasts in p57(Kip2)-/- mice were highly proliferative and had deficient maturation compared with those in wild-type (WT) mice.

  8. Data indicate that cyclin-dependent kinase inhibitor 1C (P57 was post-transcriptionally regulated by microRNA miR (show MLXIP Proteins)-221 in embryonic stem (ES) cells.

  9. Data show that disruption of potassium voltage-gated channel, KQT-like subfamily Q, member1 (KCNQ1 (show KCNQ1 Proteins)) results in increased expression of cyclin-dependent kinase inhibitor 1C (Cdkn1c) only when the mutation is on the paternal allele.

  10. Results support a model where ARX regulates the expansion of cortical progenitor cells through repression of Cdkn1c

CDKN1C Protein Profile

Protein Summary

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with CDKN1C

  • calcium and integrin binding family member 2 (CIB2)
  • cyclin-dependent kinase inhibitor 1C (Cdkn1c)
  • cyclin-dependent kinase inhibitor 1C (cdkn1c)
  • cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C)
  • cyclin-dependent kinase inhibitor 1C (P57) (Cdkn1c)
  • AL024410 protein
  • BWCR protein
  • BWS protein
  • cb961 protein
  • CDKI protein
  • DFNB48 protein
  • Kip2 protein
  • p27Xic1-a protein
  • p57 protein
  • p57(kip2) protein
  • p57Kip2 protein
  • USH1J protein
  • WBS protein
  • zgc:86618 protein

Protein level used designations for CDKN1C

2810434I23Rik , DNA-dependent protein kinase catalytic subunit-interacting protein 2 , KIP 2 , Usher syndrome 1J (autosomal recessive) , calcium and integrin-binding family member 2 , cyclin-dependent kinase inhibitor 1C, p57 , cyclin-dependent kinase inhibitor p57 , p57KIP2 A3sh , cyclin-dependent kinase inhibitor 1C (p57, Kip2) , p57kip2 , cyclin-dependent kinase inhibitor 1C

10518 Homo sapiens
246060 Rattus norvegicus
399483 Danio rerio
1028 Homo sapiens
510972 Bos taurus
12577 Mus musculus
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