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anti-Mouse (Murine) RBX1 Antibodies:
anti-Human RBX1 Antibodies:
anti-Rat (Rattus) RBX1 Antibodies:
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Caenorhabditis elegans (C. elegans) Polyclonal RBX1 Primary Antibody for EIA, IP - ABIN117957
Ohta, Michel, Schottelius, Xiong: ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. in Molecular cell 1999
Show all 11 references for ABIN117957
Cow (Bovine) Polyclonal RBX1 Primary Antibody for WB - ABIN2792171
Zheng, Schulman, Song, Miller, Jeffrey, Wang, Chu, Koepp, Elledge, Pagano, Conaway, Conaway, Harper, Pavletich: Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. in Nature 2002
Show all 2 references for ABIN2792171
Human Polyclonal RBX1 Primary Antibody for WB - ABIN1944784
Kamura, Koepp, Conrad, Skowyra, Moreland, Iliopoulos, Lane, Kaelin, Elledge, Conaway, Harper, Conaway: Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. in Science (New York, N.Y.) 1999
Show all 2 references for ABIN1944784
Human Polyclonal RBX1 Primary Antibody for IHC (p), IP - ABIN181303
Skowyra, Koepp, Kamura, Conrad, Conaway, Conaway, Elledge, Harper: Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. in Science (New York, N.Y.) 1999
oocyte maturation from pachytene exit and MPK-1 (show MAPK1 Antibodies) activation are redundantly controlled by the RBX-2-CUL-5 (show CUL5 Antibodies)- and RBX-1-CUL-2 (show CUL2 Antibodies)-based complexes.
Downregulation of Rbx1 caused accumulation of Emi1.
the early or pre-induction nuclear export of INrf2 (show KEAP1 Antibodies) in response to antioxidants is controlled by tyrosine phosphorylation, whereas the nuclear export of Cul3 (show CUL3 Antibodies) and Rbx1 is controlled by INrf2 (show KEAP1 Antibodies), allowing normal activation or repression of Nrf2 (show NFE2L2 Antibodies)
a model by which N-terminal cleavage of RBX1 impairs its activity and promotes susceptibility to ER stress induction.
Nrf2 regulates Cul3-Rbx1 by controlling regulation of expression and induction of Cul3-Rbx1
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
prothymosin-alpha (show PTMA Antibodies)-mediated nuclear import of INrf2 (show KEAP1 Antibodies)/Cul3 (show CUL3 Antibodies) Rbx1 complex leads to ubiquitination and degradation of Nrf2 (show NFE2L2 Antibodies) inside the nucleus presumably to regulate nuclear level of Nrf2 (show NFE2L2 Antibodies) and rapidly switch off the activation of Nrf2 (show NFE2L2 Antibodies) downstream gene expression.
in vivo physiological function of RBX1 is to ensure cell proliferation by preventing p27 (show CDKN1B Antibodies) accumulation during the early stage of embryonic development
ROC1 (show RIT1 Antibodies) has an important role in the malignant progression of bladder transitional cell carcinoma via the mTOR (show FRAP1 Antibodies)/DEPTOR (show DEPTOR Antibodies) pathway.
Nedd8 (show NEDD8 Antibodies)(Q40E) cannot induce the same structural effect on Cul1 (show CUL1 Antibodies)-Rbx1 as wild-type Nedd8 (show NEDD8 Antibodies).
RBX1 E3 ubiquitin protein expression responsible with multiple genetic mechanism in the development of head and neck cancer.
This work sheds new light on the roles of NEDD8 (show NEDD8 Antibodies) lysines on neddylation cascades and provides a dominant negative mutant for the study of neddylation and its biological functions.
These findings indicate that Rbx1 and Rbx2 (show RNF7 Antibodies) can both activate Cul5 (show CUL5 Antibodies)-Vif (show BTG1 Antibodies) E3 ligase in vitro, but they may undergo a more delicate selection mechanism in vivo.
upregulation of miR-194 can inhibit proliferation, migration, and invasion of GC cells, possibly by targeting RBX1. Aberrant expression of miR-194 and RBX1 is correlated to GC patient survival time.
RBX1 expression level was associated with the proliferation of gastric cancer.
Studied the DNA-level mechanisms affecting KEAP1 (show KEAP1 Antibodies)/CUL3 (show CUL3 Antibodies)/RBX1 E3-ubiquitin ligase (show MUL1 Antibodies) complex as a regulator of NRF2 (show GABPA Antibodies) levels in ovarian cancer.
eEF1A1 may mediate SAMHD1 turnover by targeting it to the proteosome for degradation through association with Cullin4A and Rbx1.
data suggest a new paradigm for Hsp90 (show HSP90 Antibodies)-modulated assembly of a Cul3 (show CUL3 Antibodies)/DBC2 (show RHOBTB2 Antibodies) E3 ubiquitin ligase (show MUL1 Antibodies) complex that may extend to other E3 ligase complexes.
The SCF (show KITLG Antibodies)-complex gene expression has been characterized during bovine preimplantation development (show MTA2 Antibodies).
This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.
E3 ubiquitin-protein ligase RBX1
, RING finger protein 75
, ring-box protein 1
, RING-box protein 1
, hyperosmotic protein 21
, RING box protein 1
, ZYP protein
, regulator of cullins 1