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Browse our SMAD2 (SMAD2) ELISA Kits

Full name:
SMAD, Mothers Against DPP Homolog 2 ELISA Kits (SMAD2)
On www.antibodies-online.com are 40 SMAD, Mothers Against DPP Homolog 2 (SMAD2) ELISA Kits from 13 different suppliers available. Additionally we are shipping SMAD2 Antibodies (408) and SMAD2 Proteins (28) and many more products for this protein. A total of 496 SMAD2 products are currently listed.
Synonyms:
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2
list all ELISA KIts Gene Name GeneID UniProt
SMAD2 4087 Q15796
SMAD2 17126 Q62432
SMAD2 29357 O70436

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Top referenced SMAD2 ELISA Kits

  1. Human SMAD2 ELISA Kit for Sandwich ELISA - ABIN417849 : Piotrowski, Kiszałkiewicz, Górski, Antczak, Górski, Pastuszak-Lewandoska, Migdalska-Sęk, Domańska-Senderowska, Nawrot, Czarnecka, Kurmanowska, Brzeziańska-Lasota: Immunoexpression of TGF-β/Smad and VEGF-A proteins in serum and BAL fluid of sarcoidosis patients. in BMC immunology 2015 (PubMed)

  2. Rat (Rattus) SMAD2 ELISA Kit for Sandwich ELISA - ABIN432538 : Kabel, Abd Elmaaboud, Albarraq: Ameliorative potential of omega 3 fatty acids and HMG-CoA reductase inhibitors on experimentally-induced non-alcoholic steatohepatitis. in Prostaglandins, leukotrienes, and essential fatty acids 2015 (PubMed)

More ELISA Kits for SMAD2 Interaction Partners

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The results of this study found that Bptf and TGF-beta (show TGFB1 ELISA Kits)/Smad2 mediate nucleosome remodeling to regulate wnt8a (show WNT8A ELISA Kits) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (show EOMES ELISA Kits) a (Eomesa (show EOMES ELISA Kits)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (show EOMES ELISA Kits) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. The nuclear importin (show KPNA4 ELISA Kits) IPO5 (show IPO5 ELISA Kits) was identified as a novel interacting protein of SMAD1 (show GARS ELISA Kits). Overexpression of IPO5 (show IPO5 ELISA Kits) in various cell lines specifically increases nuclear localization of BMP receptor (show BMPR1A ELISA Kits)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (show IPO5 ELISA Kits) and BMP but not TGF-beta (show TGFB1 ELISA Kits) R-SMADs.

  2. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (show TGFB1 ELISA Kits)/Smad2 signaling pathway, but not Smad1 (show GARS ELISA Kits)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.

  3. the findings show that TIEG1 is highly expressed in human keloids and that it directly binds and represses Smad7 (show SMAD7 ELISA Kits) promoter-mediated activation of TGF-beta (show TGFB1 ELISA Kits)/Smad2 signaling

  4. A significant association was found between the low expression of inhibitory protein SMAD-7 (show SMAD7 ELISA Kits) and both zeta-chain-associated protein kinase (show CDK7 ELISA Kits) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (show GARS ELISA Kits)/8 and lower SMAD-4 (show SMAD4 ELISA Kits) expression in chronic lymphocytic leukemia cells

  5. High expression of SMAD2 is associated with colorectal carcinoma.

  6. this study shows that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2

  7. overexpression of miR29b markedly reduced the expression levels of COL1A1 (show COL1A1 ELISA Kits) and alphaSMA (show ACTA2 ELISA Kits), and decreased the expression and nuclear accumulation of pSmad2/3.

  8. p-SMAD2/3 proteins were remarkably increased in bladder carcinoma. High p-SMAD2/3 was not statistically associated with clinicopathological characteristics of the patients. Overexpression of hepaCAM (show HEPACAM ELISA Kits) prevented the p-SMAD2/3 translocation from the cytoplasm to the nucleus in bladder cancer cells. The p-SMAD2/3 pathway is critical for hepaCAM (show HEPACAM ELISA Kits)-induced cancer cell apoptosis.

  9. silencing NLRC5 (show NLRC5 ELISA Kits) reduced extracellular matrix expression in keloid fibroblasts through inhibiting the TGF-beta1 (show TGFB1 ELISA Kits)/Smad (show SMAD1 ELISA Kits) signaling pathway.

  10. Data indicate the TGF-beta (show TGFB1 ELISA Kits) pathway regulates the epithelial-to-mesenchymal transition (EMT (show ITK ELISA Kits)) of gastric cancer cells by increasing the levels of microRNA miRNA-181b to target Timp3 (show TIMP3 ELISA Kits) via the Smad2/3/4-dependent pathway.

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. E2a (show TCF3 ELISA Kits) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  2. GDF11 (show GDF11 ELISA Kits) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  3. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (show TGFB1 ELISA Kits) signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 ELISA Kits)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 ELISA Kits).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) interaction partners

  1. In conclusion, TGF-beta (show TGFB1 ELISA Kits) signaling pathway may influence liver fibrosis by incorporating with YB-1 (show YBX1 ELISA Kits), indicating that YB-1 (show YBX1 ELISA Kits) could be a potential target for therapies against liver fibrosis.

  2. miR (show MLXIP ELISA Kits)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (show TGFB1 ELISA Kits) receptor 1 and SMAD2.

  3. hese studies revealed that Smad2 plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (show IHH ELISA Kits) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  4. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (show TGFB1 ELISA Kits).

  5. Data show that muscle-specific (show EIF3K ELISA Kits) Smad (show SMAD1 ELISA Kits) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  6. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (show WNT2 ELISA Kits) pathway, and inhibition of Smad2/3 signaling and Shh (show SHH ELISA Kits) pathways.

  7. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

  8. Smad2 and Smad3 (show SMAD3 ELISA Kits) oppositely modify STAT3 (show STAT3 ELISA Kits)-induced transcription of IL-17A (show IL17A ELISA Kits) and retinoic acid receptor (show RARA ELISA Kits)-related orphan nuclear receptor (show NR1D1 ELISA Kits), RORgammat encoded by Rorc (show RORC ELISA Kits), by acting as a co-activator and co-repressor of STAT3 (show STAT3 ELISA Kits), respectively.

  9. Endoplasmic reticulum stress in hepatic stellar cells promotes liver fibrosis by inducing over expression of SMAD2.

  10. pSmad3L-Ser (show SIGLEC1 ELISA Kits) signalling correlates with carcinogenesis of colon tumors and this work supports the hypothesis that pSmad2/3L-Thr (show TRH ELISA Kits) immunostaining-positive cells are cancer stem cells.

SMAD2 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2) Elisa Kit
  • SMAD family member 2 (smad2) Elisa Kit
  • MAD homolog 2 (Drosophila) (smad2) Elisa Kit
  • SMAD family member 2 (Smad2) Elisa Kit
  • 7120426M23Rik Elisa Kit
  • fj43c06 Elisa Kit
  • hMAD-2 Elisa Kit
  • hSMAD2 Elisa Kit
  • JV18 Elisa Kit
  • JV18-1 Elisa Kit
  • Madh2 Elisa Kit
  • Madr2 Elisa Kit
  • mMad2 Elisa Kit
  • Smad-2 Elisa Kit
  • wu:fj43c06 Elisa Kit
  • Xmad2 Elisa Kit
  • XSmad2 Elisa Kit

Protein level used designations for SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

GENE ID SPECIES
100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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