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anti-Human TFDP3 Antibodies:
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Human Polyclonal TFDP3 Primary Antibody for WB - ABIN2779483
Qiao, Di Stefano, Tian, Li, Yin, Qian, Pang, Li, McNutt, Helin, Zhang, Chen: Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. in The Journal of biological chemistry 2007
TFDP3 was highly expressed in cancer tissues including prostate cancer tissues.TFDP3 was expressed in coordination with E2F1 (show E2F1 Antibodies) in most prostate cancer tissues.
Data gathered from cell lines, tumorigenicity studies, and primary hepatocellular carcinoma samples demonstrate a negative role of HIF-2alpha (show EPAS1 Antibodies) in tumors, which is mediated by the TFDP3/E2F1 (show E2F1 Antibodies) pathway.
Data show that TFDP3 upregulates the expression of autophagy gene LC3B (show MAP1LC3B Antibodies) and inhibits E2F1 (show E2F1 Antibodies)-induced apoptosis, and may play an important role in prostate cancer.
DP-4 downregulating E2F-1 (show E2F1 Antibodies) activity and contributes to a new pRb (show RB1 Antibodies)-independent mechanism for regulating cell cycle progression.
TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F (show E2F1 Antibodies)
This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and inhibits the DNA binding and transcriptional activities of E2F factors.
, cancer/testis antigen 30
, hepatocellular carcinoma-associated antigen 661
, transcription factor Dp family member 3
, transcription factor Dp family, member 3