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Patients with GLRX5-associated variant nonketotic hyperglycemia had normal development with childhood-onset spastic paraplegia, spinal lesion, and optic atrophy.
crystal structure of GLRX5 revealed a tetrameric organization with the [2Fe-2S] clusters buried in the interior and shielded from the solvent by the conserved beta1-alpha2 loop
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts
No GLRX5 mutations were found among sixty CSA probands examined
Mutations in GLRX5 is associated with sideroblastic-like microcytic anemia and iron overload
Study reports a decrease of Grx (show GRX1 ELISA Kits) expression levels in pancreatic islets of diabetic mice which was accompanied by declining insulin (show INS ELISA Kits) secretion, increase of reactive oxygen species (ROS (show ROS1 ELISA Kits)) production level, and cell cycle alterations. These data demonstrate the essential role of the Grx (show GRX1 ELISA Kits) system for the beta-cell during metabolic stress which may provide a new target for diabetes mellitus type 2 treatment.
Grx5 is an important determinant of osteoblast apoptosis and acts via a molecular pathway that involves regulation of ROS (show ROS1 ELISA Kits) production, cardiolipin oxidation, caspase (show CASP3 ELISA Kits) activity, Fe-S cluster formation, and MnSOD (show SOD2 ELISA Kits) activity.
the hypochromic anaemia in shiraz (sir) zebrafish mutants is caused by deficiency of glutaredoxin 5 (grx5), a gene required in yeast for Fe-S cluster assembly
This gene encodes a mitochondrial protein, which is evolutionarily conserved. It is involved in the biogenesis of iron-sulfur clusters, which are required for normal iron homeostasis. Mutations in this gene are associated with autosomal recessive pyridoxine-refractory sideroblastic anemia.
glutaredoxin 5 homolog
, glutaredoxin-related protein 5, mitochondrial
, monothiol glutaredoxin-5