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Human PPP1R1A Protein expressed in Escherichia coli (E. coli) - ABIN667056
Rodriguez, Mitton, Waggoner, Kranias: Identification of a novel phosphorylation site in protein phosphatase inhibitor-1 as a negative regulator of cardiac function. in The Journal of biological chemistry 2006
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These findings suggest that the human G109E inhibitor-1 variant impairs sarcoplasmic reticulum Ca-cycling and promotes arrhythmogenesis under stress conditions.
I-1 and sarco/endoplasmic reticulum Ca2+ -ATPase (show ATP2A3 Proteins) synergistically induce the vascular smooth muscle cell contractile phenotype.
multiple domains in I-1 target cellular PP1 (show PPA1 Proteins) complexes, and I-1 has a role as a cellular regulator of eIF2alpha (show EIF2A Proteins) phosphorylation
G147D PPI-1 can attenuate responses of cardiomyocytes to beta-adrenergic agonists by decreasing PLN (show PLN Proteins) phosphorylation and therefore may contribute to deteriorated function in heart failure.
the human inhibitor-1 G147D polymorphism, found almost exclusively in blacks, may act as a modifier rather than risk factor in heart failure development
These data indicate a potential role for DARPP-32 (show PPP1R1B Proteins) and inhibitor-1 in the regulation of PP1 (show PPP1CC Proteins) activity in pancreatic beta-cell stimulus-secretion coupling.
inhibits the activity of type 1 protein phosphatase
, protein phosphatase 1 regulatory subunit 1A
, protein phosphatase inhibitor 1
, protein phosphatase inhibitor-1
, PP1 inhibitor 1
, phosphatase inhibitor 1-like protein