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anti-Human ABCA1 Antibodies:
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Chicken Polyclonal ABCA1 Primary Antibody for ChIP, ELISA - ABIN152883
Krimbou, Denis, Haidar, Carrier, Marcil, Genest: Molecular interactions between apoE and ABCA1: impact on apoE lipidation. in Journal of lipid research 2004
Show all 253 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody for ELISA, ICC - ABIN268847
Burgess, Kiss, Zheng, Zachariah, Marcel: Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux. in The Journal of biological chemistry 2002
Show all 13 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody for ELISA, IHC (fro) - ABIN268848
Murthy, Born, Mathur, Field: LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. in Journal of lipid research 2002
Show all 13 Pubmed References
Mouse (Murine) Monoclonal ABCA1 Primary Antibody for IHC (p), WB - ABIN268899
Zhou, Choi, Li, Xu, Herz: LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. in PLoS ONE 2009
Show all 6 Pubmed References
Human Polyclonal ABCA1 Primary Antibody for WB - ABIN3044206
Shang, Yu, Wang, Chen, Fang, Yang, Zhou, Nie, Zhou, Zhou: Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells. in Molecular medicine reports 2014
Show all 5 Pubmed References
Human Monoclonal ABCA1 Primary Antibody for CyTOF, FACS - ABIN4277133
Wang, Zhang, Chou, Liang, Gu, Ma: Cyclosporine stimulates the renal epithelial sodium channel by elevating cholesterol. in American journal of physiology. Renal physiology 2009
Show all 5 Pubmed References
Human Polyclonal ABCA1 Primary Antibody for WB - ABIN3043773
Chen: Effects of Chinese Herbal Compound "Xuemai Ning"on Rabbit Atherosclerosis Model and Expression of ABCA1. in International journal of biomedical science : IJBS 2013
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Mouse (Murine) Monoclonal ABCA1 Primary Antibody for WB - ABIN188209
Prasanthi, Huls, Thomasson, Thompson, Schommer, Ghribi: Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells. in Molecular neurodegeneration 2009
Mouse (Murine) Monoclonal ABCA1 Primary Antibody for FACS - ABIN2477220
Zarubica, Trompier, Chimini: ABCA1, from pathology to membrane function. in Pflügers Archiv : European journal of physiology 2007
Microparticles are lipoprotein-sized structures created by the ABCA1 transporter, and contribute approximately 30% of ABCA1-and apoA-I (show APOA1 Antibodies) mediated cholesterol efflux. MPs release from cells consists, in part, of exosomes and depends on the same pathway used for HDL (show HSD11B1 Antibodies) biogenesis.
there is an NFATc1 (show NFATC1 Antibodies)/ABCA1-dependent mechanism in which local TNF (show TNF Antibodies) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (show TNF Antibodies), TNFR1 (show TNFRSF1A Antibodies), or TNFR2 (show TNFRSF1B Antibodies) serum levels
Reduced platelet count, but no major platelet function abnormalities, are associated with loss-of-function ATP-binding cassette-1 gene mutations.
Study report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 A for the overall structure and 3.9 A for the massive extracellular domain. The nucleotide-binding domains display a nucleotide-free state, while the two transmembrane domains contact each other through a narrow interface in the intracellular leaflet of the membrane.
ABCB1 (show ABCB1 Antibodies) status is significantly associated with chemo-resistance and poor prognosis in patients with epithelial ovarian cancer
ABCA1 mediates ApoA-I (show APOA1 Antibodies) and ApoA-I (show APOA1 Antibodies) mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages.
EEPD1 is a novel LXR (show NR1H3 Antibodies)-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1.
This is the first report showing evidence of FTO (show FTO Antibodies) and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences
Pim (show PIM1 Antibodies)-1L protects hepatic ABCA1 from lysosomal degradation by facilitating the physical interaction between ABCA1 and liver X receptor beta (show NR1H2 Antibodies) and subsequent stabilization of the ABCA1-Pim (show PIM1 Antibodies)-1L complex and thereby regulates the circulating level of high-density lipoprotein.
High expression of ABCA1 is associated with high carotid intima-media thickness.
our results highlight the importance of the LXR (show NR1H3 Antibodies)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (show SCARB1 Antibodies) or ABCG1 (show ABCG1 Antibodies) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (show HSD11B1 Antibodies) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
PCSK9 (show PCSK9 Antibodies) plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.
apoA-I (show APOA1 Antibodies)/ABCA1-mediated cholesterol efflux without STAT3 (show STAT3 Antibodies) activation can reduce proinflammatory cytokine expression in macrophages.
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (show NR1H3 Antibodies)-ABCA1/ABCG1 (show ABCG1 Antibodies) cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (show HSD11B1 Antibodies)-C levels observed in patients receiving both medications
The findings obtained from apoE (show APOE Antibodies)-/- mice provide epigenetic insights into how EZH2 (show EZH2 Antibodies) increases the risk of atherosclerotic heart disease. One of the pathways by which EZH2 (show EZH2 Antibodies) leads to lipid accumulation and foam cell formation is via epigenetic downregulation of ABCA1 expression.
Overexpressed NHE1 suppresses the expression of ABCA1 protein via increasing the calpain activity in RAW264.7 cells.
Endothelial cholesterol efflux pathways mediated by ABCA1 and ABCG1 (show ABCG1 Antibodies) are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase (show NOS Antibodies) activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow.
ARF6 (show ARF6 Antibodies)-dependent pathway is the predominant route responsible for the ABCA1 internalization and degradation, whereas ARF6 (show ARF6 Antibodies)-independent endocytic pathways may contribute to ABCA1 recycling and efflux of intracellular cholesterol.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1