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ABCA1-derived nascent high-density lipoprotein-apolipoprotein AI (show APOA1 Proteins) and lipids metabolically segregate.
Hepatic free cholesterol content was significantly increased in NASH (show SAMSN1 Proteins) as compared to non-NASH (show SAMSN1 Proteins) subjects, while ABCA1 and ABCG1 (show ABCG1 Proteins) protein levels significantly decreased with NASH (show SAMSN1 Proteins) and fibrosis progression. The relative expression of miR (show MLXIP Proteins)-33a and miR (show MLXIP Proteins)-144 correlated inversely with ABCA1 but not with ABCG1 (show ABCG1 Proteins) protein levels. miR (show MLXIP Proteins)-33a/144 and their target gene ABCA1 may contribute to the pathogenesis of NASH (show SAMSN1 Proteins) in morbidly obese subjects.
Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC (show ABCB6 Proteins) transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
ABCA1 was mainly located on trophoblast membranes. Decreased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.01). while increased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.05). ABCA1 was uniformly expressed on the cell membrane, cytoplasm, and nucleus of macrophages.
AMPK (show PRKAA1 Proteins) activates LXRalpha (show NR1H3 Proteins) and ABCA1 expression in human macrophages
Microparticles are lipoprotein-sized structures created by the ABCA1 transporter, and contribute approximately 30% of ABCA1-and apoA-I (show APOA1 Proteins) mediated cholesterol efflux. MPs release from cells consists, in part, of exosomes and depends on the same pathway used for HDL (show HSD11B1 Proteins) biogenesis.
there is an NFATc1 (show NFATC1 Proteins)/ABCA1-dependent mechanism in which local TNF (show TNF Proteins) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (show TNF Proteins), TNFR1 (show TNFRSF1A Proteins), or TNFR2 (show TNFRSF1B Proteins) serum levels
Reduced platelet count, but no major platelet function abnormalities, are associated with loss-of-function ATP-binding cassette-1 gene mutations.
Study report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 A for the overall structure and 3.9 A for the massive extracellular domain. The nucleotide-binding domains display a nucleotide-free state, while the two transmembrane domains contact each other through a narrow interface in the intracellular leaflet of the membrane.
ABCB1 (show ABCB1 Proteins) status is significantly associated with chemo-resistance and poor prognosis in patients with epithelial ovarian cancer
our results highlight the importance of the LXR (show NR1H3 Proteins)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (show SCARB1 Proteins) or ABCG1 (show ABCG1 Proteins) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (show HSD11B1 Proteins) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
Rutaecarpine was identified to be a candidate that protected ApoE (show APOE Proteins)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 and SR-BI (show SCARB1 Proteins) within RCT (show FOXE3 Proteins).
Abca1 has a protective role in atherosclerosis, it exerts detrimental effects on cardiac function after myocardial infarction
Caveolin-1 (show CAV1 Proteins) enhances internalization and degradation of ABCA1 by its association with ABCA1
an important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
PCSK9 (show PCSK9 Proteins) plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.
apoA-I (show APOA1 Proteins)/ABCA1-mediated cholesterol efflux without STAT3 (show STAT3 Proteins) activation can reduce proinflammatory cytokine expression in macrophages.
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (show NR1H3 Proteins)-ABCA1/ABCG1 (show ABCG1 Proteins) cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (show HSD11B1 Proteins)-C levels observed in patients receiving both medications
The findings obtained from apoE (show APOE Proteins)-/- mice provide epigenetic insights into how EZH2 (show EZH2 Proteins) increases the risk of atherosclerotic heart disease. One of the pathways by which EZH2 (show EZH2 Proteins) leads to lipid accumulation and foam cell formation is via epigenetic downregulation of ABCA1 expression.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1