Browse our ABCA1 Proteins (ABCA1)

Full name:
ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 Proteins (ABCA1)
On www.antibodies-online.com are 8 ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) Proteins from 4 different suppliers available. Additionally we are shipping ABCA1 Antibodies (182) and ABCA1 Kits (41) and many more products for this protein. A total of 234 ABCA1 products are currently listed.
Synonyms:
ABC-1, Abc1, ABCA1, CERP, HDLDT1, TGD
list all proteins Gene Name GeneID UniProt
ABCA1 19 O95477
ABCA1 11303 P41233
Rat ABCA1 ABCA1 313210  

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ABCA1 Proteins (ABCA1) by Origin

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More Proteins for ABCA1 Interaction Partners

Cow (Bovine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. our results highlight the importance of the LXR (show NR1H3 Proteins)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.

  2. The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.

  3. Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (show SCARB1 Proteins) or ABCG1 (show ABCG1 Proteins) but not ABCA1.

Rabbit ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. Study report the cryo-EM structure of human ABCA1 with nominal resolutions of 4.1 A for the overall structure and 3.9 A for the massive extracellular domain. The nucleotide-binding domains display a nucleotide-free state, while the two transmembrane domains contact each other through a narrow interface in the intracellular leaflet of the membrane.

  2. ABCB1 (show ABCB1 Proteins) status is significantly associated with chemo-resistance and poor prognosis in patients with epithelial ovarian cancer

  3. ABCA1 mediates ApoA-I (show APOA1 Proteins) and ApoA-I (show APOA1 Proteins) mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages.

  4. EEPD1 is a novel LXR (show NR1H3 Proteins)-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1.

  5. This is the first report showing evidence of FTO (show FTO Proteins) and ABCA1 gene variant interactions affecting BMI, which may explain previously reported population differences

  6. Pim (show PIM1 Proteins)-1L protects hepatic ABCA1 from lysosomal degradation by facilitating the physical interaction between ABCA1 and liver X receptor beta (show NR1H2 Proteins) and subsequent stabilization of the ABCA1-Pim (show PIM1 Proteins)-1L complex and thereby regulates the circulating level of high-density lipoprotein.

  7. High expression of ABCA1 is associated with high carotid intima-media thickness.

  8. Thyrotropin regulated cholesterol content and ABCA1 expression in hepG2 cells.

  9. This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to coronary heart disease (CHD (show CHDH Proteins)) while the CRP (show CRP Proteins) +1059G/C polymorphism appears to have no correlation with susceptibility to CHD (show CHDH Proteins).

  10. ApoA-I (show APOA1 Proteins) induces S1P (show MBTPS1 Proteins) release from endothelial cells through ABCA1 and SR-BI (show SCARB1 Proteins) in a positive feedback manner.

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. The findings obtained from apoE (show APOE Proteins)-/- mice provide epigenetic insights into how EZH2 (show EZH2 Proteins) increases the risk of atherosclerotic heart disease. One of the pathways by which EZH2 (show EZH2 Proteins) leads to lipid accumulation and foam cell formation is via epigenetic downregulation of ABCA1 expression.

  2. Overexpressed NHE1 suppresses the expression of ABCA1 protein via increasing the calpain activity in RAW264.7 cells.

  3. Endothelial cholesterol efflux pathways mediated by ABCA1 and ABCG1 are nonredundant and atheroprotective, reflecting preservation of endothelial NO synthase activity and suppression of endothelial inflammation, especially in regions of disturbed arterial blood flow.

  4. ABCA1 mediates ApoA-I (show APOA1 Proteins) and ApoA-I (show APOA1 Proteins) mimetic peptide mobilization of extracellular cholesterol microdomains deposited by macrophages.

  5. ARF6 (show ARF6 Proteins)-dependent pathway is the predominant route responsible for the ABCA1 internalization and degradation, whereas ARF6 (show ARF6 Proteins)-independent endocytic pathways may contribute to ABCA1 recycling and efflux of intracellular cholesterol.

  6. EEPD1 is a novel LXR (show NR1H3 Proteins)-regulated gene in macrophages and that it promotes cellular cholesterol efflux by controlling cellular levels and activity of ABCA1.

  7. Pim (show PIM1 Proteins)-1L protects hepatic ABCA1 from lysosomal degradation by facilitating the physical interaction between ABCA1 and liver X receptor beta (show NR1H2 Proteins) and subsequent stabilization of the ABCA1-Pim (show PIM1 Proteins)-1L complex and thereby regulates the circulating level of high-density lipoprotein.

  8. Nucleolin (show NCL Proteins) protects macrophages from oxLDL-induced foam cell formation in hyperlipidemia through up-regulating ABCA1 expression.

  9. This study suggests that enhancement of macrophage cholesterol metabolism by PPARgammais not contributed by activating ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI, which is not involved by CD36 (show CD36 Proteins) expression either.

  10. exendin-4 increases ABCA1 expression in glomerular endothelial cells, which plays an important role in alleviating renal lipid accumulation, inflammation, and proteinuria in mice with type 2 diabetes.

Pig (Porcine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. ABCA1 promoter variants affect transcription activity and plasma HDL (show HSD11B1 Proteins) level in pigs

  2. ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.

  3. Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia

ABCA1 Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

Alternative names and synonyms associated with ABCA1

  • ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1)
  • ATP-binding cassette, sub-family A (ABC1), member 1 (abca1)
  • ATP-binding cassette, sub-family A (ABC1), member 1 (Abca1)
  • ATP-binding cassette, subfamily A (ABC1), member 1 (Abca1)
  • ABC-1 protein
  • Abc1 protein
  • ABCA1 protein
  • CERP protein
  • HDLDT1 protein
  • TGD protein

Protein level used designations for ABCA1

ATP-binding cassette, sub-family A member 1 , ATP-binding cassette transporter 1 , Cholesterol efflux regulatory protein , ATP-binding cassette sub-family A member 1 , ATP-binding cassette transporter , ATP-binding cassette, sub-family A (ABC1), member 1 , ATP-binding cassette, sub-family A member 1-like , ATP-binding cassette sub-family A member 1-like , ATP-binding cassette transporter A1 , cholesterol efflux regulatory protein , membrane-bound , ATP-binding cassette 1

GENE ID SPECIES
464630 Pan troglodytes
535379 Bos taurus
100013781 Monodelphis domestica
100356765 Oryctolagus cuniculus
100441342 Pongo abelii
100483394 Ailuropoda melanoleuca
100491942 Xenopus (Silurana) tropicalis
716107 Macaca mulatta
100557081 Anolis carolinensis
373945 Gallus gallus
19 Homo sapiens
11303 Mus musculus
481651 Canis lupus familiaris
100152112 Sus scrofa
313210 Rattus norvegicus
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