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Browse our ABCA1 Proteins (ABCA1)

Full name:
ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 Proteins (ABCA1)
On www.antibodies-online.com are 8 ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) Proteins from 4 different suppliers available. Additionally we are shipping ABCA1 Antibodies (180) and ABCA1 Kits (38) and many more products for this protein. A total of 229 ABCA1 products are currently listed.
Synonyms:
ABC-1, Abc1, ABCA1, CERP, HDLDT1, TGD
list all proteins Gene Name GeneID UniProt
ABCA1 19 O95477
ABCA1 11303 P41233
Rat ABCA1 ABCA1 313210  

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ABCA1 Proteins (ABCA1) by Origin

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More Proteins for ABCA1 Interaction Partners

Cow (Bovine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. our results highlight the importance of the LXR (show NR1H3 Proteins)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.

  2. The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.

  3. Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (show SCARB1 Proteins) or ABCG1 (show ABCG1 Proteins) but not ABCA1.

Rabbit ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.

Human ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. This meta-analysis provides convincing evidence that polymorphism of ABCA1 R219K is associated with susceptibility to coronary heart disease (CHD (show CHDH Proteins)) while the CRP (show CRP Proteins) +1059G/C polymorphism appears to have no correlation with susceptibility to CHD (show CHDH Proteins).

  2. ApoA-I (show APOA1 Proteins) induces S1P (show MBTPS1 Proteins) release from endothelial cells through ABCA1 and SR-BI (show SCARB1 Proteins) in a positive feedback manner.

  3. Results suggest that enhanced expression of miR (show MLXIP Proteins)-33a might induce cholesterol accumulation and aggravate inflammation in vessel walls by suppressing the expression of ABCA1 in macrophages.

  4. AIBP (show APOA1BP Proteins) promotes apoA-1 (show APOA1 Proteins) binding to ABCA1 on the cell membrane of macrophages and prevents ABCA1 protein from CSN2 (show CSN2 Proteins)-mediated degradation so as to prevent foam cell formation

  5. ABCA1 gene expression positively correlated with obesity indicators.

  6. The results of this study indicated that ABCA1 rs2422493 polymorphism was statistically significant associated with increasing Alzheimer's disease risk.

  7. These findings suggest that some common variants on the chromosome 9p21 and ABCA1 and their interactions may significantly modify the risk of Coronary Heart Disease and is independent of effects on serum lipid levels.

  8. In people with mild cognitive impairement and Alzheimer disease, the capacity of CSF (show CSF2 Proteins) to facilitate ABCA1-mediated cholesterol efflux is impaired.

  9. miR (show MLXIP Proteins)-183 degrades ABCA1 mRNA in colon cancer cells.

  10. Absence of ABCA1 and low HDL (show HSD11B1 Proteins) level induce reduction of platelet reactivity by decreasing positive feedback loops, particularly TXA2 (show TBXA2R Proteins) production through a hematopoietic ABCA1-independent mechanism.

Mouse (Murine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. The ABCA1 may serve as an important feedback mechanism to modulate the magnitude of subsequent phagocytotic process of SCs (show TWIST1 Proteins) in response to testicular injury.

  2. Absence of ABCA1 and low HDL (show HSD11B1 Proteins) level induce reduction of platelet reactivity by decreasing positive feedback loops, particularly TXA2 (show TBXA2R Proteins) production through a hematopoietic ABCA1-independent mechanism.

  3. Both depletion of PARP-1 (show PARP1 Proteins) and inhibition of PARP-1 (show PARP1 Proteins) activity augmented LXR (show NR1H3 Proteins) ligand-induced ABCA1 expression in the RAW 264.7 macrophage line and primary bone marrow-derived macrophages but did not affect LXR (show NR1H3 Proteins)-dependent expression of other target genes, ABCG1 (show ABCG1 Proteins) and SREBP-1c (show SREBF1 Proteins).

  4. Visfatin (show NAMPT Proteins) upregulated CD36 (show CD36 Proteins) and SRA (show MSR1 Proteins) expression and downregulated ABCA1 and ABCG1 (show ABCG1 Proteins) expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (show EPHB2 Proteins)-dependent pathways.

  5. These studies point to an important role for hematopoietic ABCA1 in modulating a feed-forward mechanism in obesity such that inflamed tissue macrophages stimulate the production of more monocytes, leading to an exacerbation of inflammation and associated disease processes.

  6. These findings may be clinically relevant because HDL's APOE (show APOE Proteins) content associates with CVD risk and ABCA1 deficiency promotes unregulated cholesterol accumulation in human macrophages.

  7. Short-term modulation of miR (show MLXIP Proteins)-27b expression in wild-type mice regulates hepatic LDLR (show LDLR Proteins) and ABCA1 expression but does not influence plasma and hepatic lipid levels.

  8. LXR (show NR1H3 Proteins) activation reduces the growth of xenograft tumour of human oral squamous cell carcinoma cells in mice accompanied by the upregulation of ABCA1 expression and the decline of cholesterol levels in the tumour.

  9. PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages

  10. ABCA1(-/-) macrophages deposited much less extracellular cholesterol than wild-type macrophages. These findings demonstrate a novel function of ABCA1 in contributing to macrophage export of cholesterol into the extracellular matrix.

Pig (Porcine) ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1) interaction partners

  1. ABCA1 promoter variants affect transcription activity and plasma HDL (show HSD11B1 Proteins) level in pigs

  2. ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.

  3. Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia

ABCA1 Protein Profile

Protein Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.

Alternative names and synonyms associated with ABCA1

  • ATP-binding cassette, sub-family A (ABC1), member 1 (ABCA1)
  • ATP-binding cassette, sub-family A (ABC1), member 1 (abca1)
  • ATP-binding cassette, sub-family A (ABC1), member 1 (Abca1)
  • ATP-binding cassette, subfamily A (ABC1), member 1 (Abca1)
  • ABC-1 protein
  • Abc1 protein
  • ABCA1 protein
  • CERP protein
  • HDLDT1 protein
  • TGD protein

Protein level used designations for ABCA1

ATP-binding cassette, sub-family A member 1 , ATP-binding cassette transporter 1 , Cholesterol efflux regulatory protein , ATP-binding cassette sub-family A member 1 , ATP-binding cassette transporter , ATP-binding cassette, sub-family A (ABC1), member 1 , ATP-binding cassette, sub-family A member 1-like , ATP-binding cassette sub-family A member 1-like , ATP-binding cassette transporter A1 , cholesterol efflux regulatory protein , membrane-bound , ATP-binding cassette 1

GENE ID SPECIES
464630 Pan troglodytes
535379 Bos taurus
100013781 Monodelphis domestica
100356765 Oryctolagus cuniculus
100441342 Pongo abelii
100483394 Ailuropoda melanoleuca
100491942 Xenopus (Silurana) tropicalis
716107 Macaca mulatta
100557081 Anolis carolinensis
373945 Gallus gallus
19 Homo sapiens
11303 Mus musculus
481651 Canis lupus familiaris
100152112 Sus scrofa
313210 Rattus norvegicus
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