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Data show that both CEBPE and SMARCD2 (show SMARCD2 Proteins) loss-of-function mutations identified in patients with neutrophil-specific granule deficiency (SGD (show SGCD Proteins)) abolish the interaction with SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) and secondary granule gene expression, thus providing a molecular basis for this disease.
PML (show PML Proteins)/RARalpha (show RARA Proteins) synergizes with C/EBPepsilon to reactivate the C/EBPepsilon target G0S2 (show G0S2 Proteins), thereby contributing to All-trans retinoic acid -mediated acute promyelocytic leukemia (show PML Proteins) differentiation and potentially, clinical remission.
the rs7088318 (PIP4K2A (show PIP4K2A Proteins)) and rs2239633 (CEBPE) polymorphisms were not associated with ALL risk.
The minor allele of the CEBPE variant associated with lower basophil count has been previously associated with Amerindian ancestry and higher risk of acute lymphoblastic leukemia in Hispanics.
variants within IKZF1 (show IKZF1 Proteins), ARID5B (show ARID5B Proteins), and CEBPE were associated with pediatric ALL risks.
Genotypic and allelic frequencies differed significantly between cases and controls at IKZF1 (show IKZF1 Proteins)-rs4132601 (p=0.039, p=0.015) and ARID5B (show ARID5B Proteins)-rs10821936 (p=0.028, p=0.026).
variants within IKZF1 (show IKZF1 Proteins), ARID5B (show ARID5B Proteins), and CEBPE were associated with increased acute lymphoblastic leukemia (ALL) risk, and the effects for ARID5B (show ARID5B Proteins) and CEBPE were most prominent in high-hyperdiploid ALL subtype in the California Hispanic population
Data indicate no significant associations of transcription factors rs4132601 (IKZF1), rs7089424 (ARID5B) and rs2239633 (CEBPE) with risk of pediatric non-Hodgkin lymphoma (NHL).
our study provided evidence that CEBPE rs2239633 variant is associated with decreased risk of childhood B-cell ALL in Europeans.
A novel in-frame deletion in the leucine zipper domain of CEBPE leads to neutrophil-specific granule deficiency.
study suggests that the myeloid specific factor C/EBPepsilon is involved in systemic lipid metabolism and that silencing of C/EBPepsilon could decrease the development of atherosclerosis.
in the absence of CCAAT enhancer binding protein epsilon (C/EBPepsilon), there is not only incomplete differentiation of granulocytes, but myelopoiesis is disrupted and neutrophils have abnormal chemotaxis
C/EBP epsilon gene as an important transcription factor required for normal function and development of macrophages.
C/EBPepsilon interacts with Rb and E2F1 (show E2F1 Proteins) during granulocytic differentiation
in the later stages of myeloid development, MMP8 (show MMP8 Proteins) and other SGP genes are coordinately upregulated, and members of the C/EBP (show CEBPA Proteins) family, in particular C/EBPalpha (show CEBPA Proteins) and C/EBPepsilon, play specific and unique roles in upregulating their expression
Gfi-1 down-regulates C/EBPepsilon expression; increased expression of C/EBPepsilon as a consequence of loss of Gfi-1 function may be deleterious to the proliferation and survival of early myeloid cells
the N terminus of C/EBPepsilon is solely responsible for most aspects of myeloid differentiation, and these events are differentially affected by c-Myc (show MYC Proteins)
the requirement for C/EBP epsilon in mediating BPI (show BPI Proteins) gene expression in myeloid cells in vitro and in vivo.
The type IV isoform of PML (show PML Proteins) interacted with PU.1, promoted its association with p300 (show NOTCH1 Proteins), and then enhanced PU.1-induced transcription and granulocytic differentiation and PU.1 directly activates the transcription of the C/EBPepsilon gene.
Phosphorylation of PML (show PML Proteins) was required for stimulating C/EBP epsilon-dependent transcription and accelerating C/EBP epsilon-induced granulocytic differentiation.
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.
CCAAT/enhancer binding protein (C/EBP), epsilon
, CCAAT/enhancer-binding protein epsilon
, CCAAT/enhancer binding protein epsilon
, c/EBP epsilon
, C/EBP-related protein 1
, CCAAT/enhancer binding protein , epsilon
, c/EBP-related protein 1